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[The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia].
Zhonghua Nei Ke Za Zhi. 2002 Mar; 41(3):183-5.ZN

Abstract

OBJECTIVE

To evaluate the relationship between the expression of lung resistance-related protein (lrp) gene or multidrug resistance-associated protein (mrp) gene and prognosis in untreated acute leukemia (AL) patients.

METHODS

Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to examine the expression of lrp and mrp gene in 58 newly diagnosed AL patients.

RESULTS

The positive rate of lrp and mrp gene expression in newly diagnosed acute lymphocytic leukemia (ALL) group was 15.0% and 40.0% and it was 15.8% and 42.1% in newly diagnosed acute nonlymphocytic leukemia (ANLL) group. In both the ALL and ANLL groups, the difference of the first complete remission rate in lrp negative and in lrp positive patients was not significant (P > 0.05), the same results were found with mrp gene. The difference of the first complete remission rate between lrp(+)/mrp(+) and lrp(-)/mrp(-) patients was significant (P < 0.05). There was no relationship between lrp and mrp gene.

CONCLUSION

Neither lrp nor mrp gene as a single indicator to forecast original multidrug resistance is sensitive, but lrp combined with mrp as one indicator will be sensitive.

Authors+Show Affiliations

Hematology Department, The General Hospital of PLA. Beijing 100853, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

11940320

Citation

Zhao, Yu, et al. "[The Relationship Between Expression of Lung Resistance-related Protein Gene or Multidrug Resistance-associated Protein Gene and Prognosis in Newly Diagnosed Acute Leukemia]." Zhonghua Nei Ke Za Zhi, vol. 41, no. 3, 2002, pp. 183-5.
Zhao Y, Yu L, Wang Q, et al. [The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia]. Zhonghua Nei Ke Za Zhi. 2002;41(3):183-5.
Zhao, Y., Yu, L., Wang, Q., Lou, F., & Pu, J. (2002). [The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia]. Zhonghua Nei Ke Za Zhi, 41(3), 183-5.
Zhao Y, et al. [The Relationship Between Expression of Lung Resistance-related Protein Gene or Multidrug Resistance-associated Protein Gene and Prognosis in Newly Diagnosed Acute Leukemia]. Zhonghua Nei Ke Za Zhi. 2002;41(3):183-5. PubMed PMID: 11940320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia]. AU - Zhao,Yu, AU - Yu,Li, AU - Wang,Quanshun, AU - Lou,Fangding, AU - Pu,Jing, PY - 2002/4/10/pubmed PY - 2002/10/9/medline PY - 2002/4/10/entrez SP - 183 EP - 5 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 41 IS - 3 N2 - OBJECTIVE: To evaluate the relationship between the expression of lung resistance-related protein (lrp) gene or multidrug resistance-associated protein (mrp) gene and prognosis in untreated acute leukemia (AL) patients. METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to examine the expression of lrp and mrp gene in 58 newly diagnosed AL patients. RESULTS: The positive rate of lrp and mrp gene expression in newly diagnosed acute lymphocytic leukemia (ALL) group was 15.0% and 40.0% and it was 15.8% and 42.1% in newly diagnosed acute nonlymphocytic leukemia (ANLL) group. In both the ALL and ANLL groups, the difference of the first complete remission rate in lrp negative and in lrp positive patients was not significant (P > 0.05), the same results were found with mrp gene. The difference of the first complete remission rate between lrp(+)/mrp(+) and lrp(-)/mrp(-) patients was significant (P < 0.05). There was no relationship between lrp and mrp gene. CONCLUSION: Neither lrp nor mrp gene as a single indicator to forecast original multidrug resistance is sensitive, but lrp combined with mrp as one indicator will be sensitive. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/11940320/[The_relationship_between_expression_of_lung_resistance_related_protein_gene_or_multidrug_resistance_associated_protein_gene_and_prognosis_in_newly_diagnosed_acute_leukemia]_ L2 - https://biocyc.org/gene?orgid=HUMAN&amp;id=HS00345 DB - PRIME DP - Unbound Medicine ER -