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Comparison of three doses of enalapril in preventing left ventricular remodeling after acute myocardial infarction in the rat.
Chin Med J (Engl). 2002 Mar; 115(3):347-51.CM

Abstract

OBJECTIVE

To compare the effects of high, middle and low doses of enalapril in preventing left ventricular remodeling (LVRM) after acute myocardial infarction (AMI) in rats, especially evaluating the efficacy of low dose enalapril.

METHODS

AMI was induced by ligating the left coronary artery in 149 female SD rats. 48 hours after the procedure, the 97 surviving rats were randomized to one of the following four groups: (1) AMI controls (n = 24), (2) high-dose (10 mg x kg(-1) x d(-1), n = 25), (3) middle-dose (1 mg x kg(-1) x d(-1), n = 23), and (4) low-dose (0.1 mg x kg(-1) x d(-1), n = 25) enalapril groups. In addition, sham-operated (n = 13) and normal rats (n = 10) were randomly selected to serve as non-infarction controls. Enalapril was delivered by direct gastric gavage. After 4 weeks of therapy, hemodynamic studies were performed, then the rat hearts were fixed with 10% formalin and pathology analysis was performed. Exclusive of the dead rats and those with MI size < 35% or > 55%, complete experimental data were obtained from 67 rats, which were comprised of (1) AMI controls (n = 13), (2) high-dose enalapril (n = 13), (3) middle-dose enalapril (n = 12), (4) low-dose enalapril (n = 12), (5) sham-operated (n = 8) and (6) normal (n = 9) groups.

RESULTS

There were no significant differences among the four AMI groups in infarction size (all P > 0.05). Compared with the sham-operated group, the left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV), absolute and relative weight (LVAW, LVRW) in AMI group were all significantly increased (all P < 0.001), while maximum LV pressure rising and dropping rates (+/- dp/dt) and their corrected values by LV systolic pressure (+/- dp/dt/LVSP) were all significantly reduced in the AMI control group (P < 0.01 - 0.001), indicating LVRM occurred and LV systolic and diastolic functions were impaired. Compared with the AMI group, LVEDP, LVV, LVAW and LVRW were all significantly decreased in the three enalapril groups (control P < 0.001), with the reduction of LVEDP, LVV and LVAW being more significant in high-dose than in low-dose enalapril groups (all P < 0.05), and the +/- dp/dt/LVSP were significantly increased only in the high and middle-dose enalapril groups (P < 0.01).

CONCLUSIONS

High, middle and low doses of enalapril were all effective in preventing LVRM after AMI in the rat, with low dose enalapril being effective and high dose superior. As for LV functional improvement, only high and middle-dose enalapril were effective.

Authors+Show Affiliations

Division of Coronary Heart Disease, Cardiovascular Institute & Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing 100037, China. pzhmd@sina.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11940361

Citation

Yang, Yuejin, et al. "Comparison of Three Doses of Enalapril in Preventing Left Ventricular Remodeling After Acute Myocardial Infarction in the Rat." Chinese Medical Journal, vol. 115, no. 3, 2002, pp. 347-51.
Yang Y, Zhang P, Song L, et al. Comparison of three doses of enalapril in preventing left ventricular remodeling after acute myocardial infarction in the rat. Chin Med J (Engl). 2002;115(3):347-51.
Yang, Y., Zhang, P., Song, L., Ruan, Y., Xu, X., Li, Y., Zhou, Y., Tian, Y., Xu, Y., & Chen, Z. (2002). Comparison of three doses of enalapril in preventing left ventricular remodeling after acute myocardial infarction in the rat. Chinese Medical Journal, 115(3), 347-51.
Yang Y, et al. Comparison of Three Doses of Enalapril in Preventing Left Ventricular Remodeling After Acute Myocardial Infarction in the Rat. Chin Med J (Engl). 2002;115(3):347-51. PubMed PMID: 11940361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of three doses of enalapril in preventing left ventricular remodeling after acute myocardial infarction in the rat. AU - Yang,Yuejin, AU - Zhang,Pei, AU - Song,Laifeng, AU - Ruan,Yingmao, AU - Xu,Xinlin, AU - Li,Yongli, AU - Zhou,Yanwen, AU - Tian,Yi, AU - Xu,Yishu, AU - Chen,Zaijia, PY - 2002/4/10/pubmed PY - 2002/5/2/medline PY - 2002/4/10/entrez SP - 347 EP - 51 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 115 IS - 3 N2 - OBJECTIVE: To compare the effects of high, middle and low doses of enalapril in preventing left ventricular remodeling (LVRM) after acute myocardial infarction (AMI) in rats, especially evaluating the efficacy of low dose enalapril. METHODS: AMI was induced by ligating the left coronary artery in 149 female SD rats. 48 hours after the procedure, the 97 surviving rats were randomized to one of the following four groups: (1) AMI controls (n = 24), (2) high-dose (10 mg x kg(-1) x d(-1), n = 25), (3) middle-dose (1 mg x kg(-1) x d(-1), n = 23), and (4) low-dose (0.1 mg x kg(-1) x d(-1), n = 25) enalapril groups. In addition, sham-operated (n = 13) and normal rats (n = 10) were randomly selected to serve as non-infarction controls. Enalapril was delivered by direct gastric gavage. After 4 weeks of therapy, hemodynamic studies were performed, then the rat hearts were fixed with 10% formalin and pathology analysis was performed. Exclusive of the dead rats and those with MI size < 35% or > 55%, complete experimental data were obtained from 67 rats, which were comprised of (1) AMI controls (n = 13), (2) high-dose enalapril (n = 13), (3) middle-dose enalapril (n = 12), (4) low-dose enalapril (n = 12), (5) sham-operated (n = 8) and (6) normal (n = 9) groups. RESULTS: There were no significant differences among the four AMI groups in infarction size (all P > 0.05). Compared with the sham-operated group, the left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV), absolute and relative weight (LVAW, LVRW) in AMI group were all significantly increased (all P < 0.001), while maximum LV pressure rising and dropping rates (+/- dp/dt) and their corrected values by LV systolic pressure (+/- dp/dt/LVSP) were all significantly reduced in the AMI control group (P < 0.01 - 0.001), indicating LVRM occurred and LV systolic and diastolic functions were impaired. Compared with the AMI group, LVEDP, LVV, LVAW and LVRW were all significantly decreased in the three enalapril groups (control P < 0.001), with the reduction of LVEDP, LVV and LVAW being more significant in high-dose than in low-dose enalapril groups (all P < 0.05), and the +/- dp/dt/LVSP were significantly increased only in the high and middle-dose enalapril groups (P < 0.01). CONCLUSIONS: High, middle and low doses of enalapril were all effective in preventing LVRM after AMI in the rat, with low dose enalapril being effective and high dose superior. As for LV functional improvement, only high and middle-dose enalapril were effective. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/11940361/Comparison_of_three_doses_of_enalapril_in_preventing_left_ventricular_remodeling_after_acute_myocardial_infarction_in_the_rat_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -