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[Short history of L-Dopa].
Neurologia. 2002 Apr; 17(4):214-7.N

Abstract

The introduction of L-Dopa has been a landmark in Neuroscience. Before the use of L-Dopa, Parkinson's disease (PD) was considered a disabling disease with no effective treatment. The development of L-Dopa followed a rationale approach: first, the discovery of dopamine deficiency in the striatum of patients with PD; and then the use of precursor of dopamine. Overall, the whole process took less than 12 years; this is a remarkable short time taking into account that the development of a similar crucial drug such as insulin took 50 years. In addition, the success of L-Dopa stimulated the neurochemistry research for all neurodegenerative diseases.

Authors+Show Affiliations

Unidad de Movimientos Anormales, Servicio de Neurología, Fundación Jiménez Díaz, Madrid, Spain. pgarcia@fjd.esNo affiliation info available

Pub Type(s)

English Abstract
Historical Article
Journal Article

Language

spa

PubMed ID

11940409

Citation

García Ruiz, P J., and E Meseguer. "[Short History of L-Dopa]." Neurologia (Barcelona, Spain), vol. 17, no. 4, 2002, pp. 214-7.
García Ruiz PJ, Meseguer E. [Short history of L-Dopa]. Neurologia. 2002;17(4):214-7.
García Ruiz, P. J., & Meseguer, E. (2002). [Short history of L-Dopa]. Neurologia (Barcelona, Spain), 17(4), 214-7.
García Ruiz PJ, Meseguer E. [Short History of L-Dopa]. Neurologia. 2002;17(4):214-7. PubMed PMID: 11940409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Short history of L-Dopa]. AU - García Ruiz,P J, AU - Meseguer,E, PY - 2002/4/10/pubmed PY - 2002/11/26/medline PY - 2002/4/10/entrez SP - 214 EP - 7 JF - Neurologia (Barcelona, Spain) JO - Neurologia VL - 17 IS - 4 N2 - The introduction of L-Dopa has been a landmark in Neuroscience. Before the use of L-Dopa, Parkinson's disease (PD) was considered a disabling disease with no effective treatment. The development of L-Dopa followed a rationale approach: first, the discovery of dopamine deficiency in the striatum of patients with PD; and then the use of precursor of dopamine. Overall, the whole process took less than 12 years; this is a remarkable short time taking into account that the development of a similar crucial drug such as insulin took 50 years. In addition, the success of L-Dopa stimulated the neurochemistry research for all neurodegenerative diseases. SN - 0213-4853 UR - https://www.unboundmedicine.com/medline/citation/11940409/[Short_history_of_L_Dopa]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -