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[Inhibition of transmembrane K(+) currents in mammalian ventricular myocytes by antiarrhythmic agent RP62719].
Sheng Li Xue Bao. 2000 Oct; 52(5):427-30.SL

Abstract

The effect of RP62719 on the inward rectifier K(+) current (I(K1)),transient outward K(+) current (I(to)) and delayed outward K(+) current (I(K)) in isolated cardiac myocytes was determined using the whole cell patch clamp technique in guinea pig and dog. RP62719 decreased I(K1) with an inhibitory concentration 50 (IC(50)) of 5.0+/-1.0 micromol/L at -100 mV in guinea pig ventricular cells. In dog ventricular myocytes, RP62719 inhibited Ito by 84+/-4.4% with an IC(50) of 1.2+/-0.51 micromol/L at +40 mV. In guinea pig ventricular cells, RP62719 decreased I(K): I(Kstep) by 50.0+/-8.3%%and I(Ktail) by 56.0+/-4.9% at +40 mV, respectively. RP62719 inhibited I(Kstep) with an IC(50) of 4.2+/-0.8 micromol/L and I(Ktail) with an IC(50) of 3.3+/-0.75 micromol/L. Thus it is suggested that the ionic mechanism of antiarrhymic effect by RP62719 may be due to its inhibition of I(K1),I(to) and I(K).

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Authors+Show Affiliations

Li YR
Department of Physiology, Harbin Medical University, Harbin 150086, China.
Yang BF
No affiliation info available
Xu CQ
No affiliation info available
Zhou J
No affiliation info available
Yang YB
No affiliation info available
Zhang JY
No affiliation info available
Sun MZ
No affiliation info available

MeSH

AnimalsAnti-Arrhythmia AgentsCell SeparationChromansDogsGuinea PigsHeart VentriclesInhibitory Concentration 50Myocytes, CardiacPatch-Clamp TechniquesPiperidinesPotassium ChannelsPotassium Channels, Inwardly Rectifying

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11941400

Citation

Li, Y R., et al. "[Inhibition of Transmembrane K(+) Currents in Mammalian Ventricular Myocytes By Antiarrhythmic Agent RP62719]." Sheng Li Xue Bao : [Acta Physiologica Sinica], vol. 52, no. 5, 2000, pp. 427-30.
Li YR, Yang BF, Xu CQ, et al. [Inhibition of transmembrane K(+) currents in mammalian ventricular myocytes by antiarrhythmic agent RP62719]. Sheng Li Xue Bao. 2000;52(5):427-30.
Li, Y. R., Yang, B. F., Xu, C. Q., Zhou, J., Yang, Y. B., Zhang, J. Y., & Sun, M. Z. (2000). [Inhibition of transmembrane K(+) currents in mammalian ventricular myocytes by antiarrhythmic agent RP62719]. Sheng Li Xue Bao : [Acta Physiologica Sinica], 52(5), 427-30.
Li YR, et al. [Inhibition of Transmembrane K(+) Currents in Mammalian Ventricular Myocytes By Antiarrhythmic Agent RP62719]. Sheng Li Xue Bao. 2000;52(5):427-30. PubMed PMID: 11941400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Inhibition of transmembrane K(+) currents in mammalian ventricular myocytes by antiarrhythmic agent RP62719]. AU - Li,Y R, AU - Yang,B F, AU - Xu,C Q, AU - Zhou,J, AU - Yang,Y B, AU - Zhang,J Y, AU - Sun,M Z, PY - 2002/4/10/pubmed PY - 2002/12/11/medline PY - 2002/4/10/entrez SP - 427 EP - 30 JF - Sheng li xue bao : [Acta physiologica Sinica] JO - Sheng Li Xue Bao VL - 52 IS - 5 N2 - The effect of RP62719 on the inward rectifier K(+) current (I(K1)),transient outward K(+) current (I(to)) and delayed outward K(+) current (I(K)) in isolated cardiac myocytes was determined using the whole cell patch clamp technique in guinea pig and dog. RP62719 decreased I(K1) with an inhibitory concentration 50 (IC(50)) of 5.0+/-1.0 micromol/L at -100 mV in guinea pig ventricular cells. In dog ventricular myocytes, RP62719 inhibited Ito by 84+/-4.4% with an IC(50) of 1.2+/-0.51 micromol/L at +40 mV. In guinea pig ventricular cells, RP62719 decreased I(K): I(Kstep) by 50.0+/-8.3%%and I(Ktail) by 56.0+/-4.9% at +40 mV, respectively. RP62719 inhibited I(Kstep) with an IC(50) of 4.2+/-0.8 micromol/L and I(Ktail) with an IC(50) of 3.3+/-0.75 micromol/L. Thus it is suggested that the ionic mechanism of antiarrhymic effect by RP62719 may be due to its inhibition of I(K1),I(to) and I(K). SN - 0371-0874 UR - https://www.unboundmedicine.com/medline/citation/11941400/[Inhibition_of_transmembrane_K_+__currents_in_mammalian_ventricular_myocytes_by_antiarrhythmic_agent_RP62719]_ L2 - http://www.actaps.com.cn/paper/200005/article/2000-5-15.pdf DB - PRIME DP - Unbound Medicine ER -