Tags

Type your tag names separated by a space and hit enter

[Transmission disequilibrium test of DRD4 exon III 48bp variant number tandem repeat polymorphism and tic disorder].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Apr; 19(2):100-3.ZY

Abstract

OBJECTIVE

To investigate whether DRD4 exon III48 bp variant number tandem repeat(VNTR) polymorphism is associated with tic disorder.

METHODS

One hundred and twenty-two nucleus families were collected using Structured clinical interview for genetic study of Tourette syndrome and related disorders for family-based association analysis of tic disorder and DRD4 exon III 48bp VNTR polymorphism. One hundred and twenty-two trios were divided into two groups: tic disorder group (82 trios of Tourette syndrome or chronic tic disorder, TS&CT) and tic disorder accompanied with attention deficit and hyperactivity disorder (ADHD) group (40 trios of Tourette syndrome or chronic tic disorder accompanied with ADHD, TS&ADHD). Transmission disequilibrium test (TDT), in addition to polymerase chain reaction and VNTR technique were conducted in 122 trios.

RESULTS

There exist 5 alleles at this polymorphic locus in this sample including DRD4 exon III 48bp 2-6 repeats. No transmission disequilibrium was found between DRD4 exon III 48 bp VNTR and tic disorder (chi square=7.44, P 0.12); however, when the sample was divided into two groups, transmission disequilibrium was noticed between the cases of TS&ADHD and this locus by overall allele-wise analysis (chi square=11.74, P 0.02), and there exists transmission disequilibrium exclusively between 5 or 6 repeats of 48bp VNTR(longer alleles) by allele-wise analysis (chi square=10.57, P 0.032, chi square=6.13, P 0.01). No transmission disequilibrium was seen between TS&CT and DRD4 exon III 48bp VNTR(chi square=3.38, P 0.50).

CONCLUSION

The results of this study have revealed an association between the longer alleles of DRD4 exon III 48bp VNTR polymorphism and tic disorder accompanied with ADHD, thus suggesting a possible genetic risk factor of tic disorder accompanied with ADHD in Chinese.

Authors+Show Affiliations

Institute of Mental Health, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. cdwangyun@mail.sc.cninfo.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11941581

Citation

Huang, Yi, et al. "[Transmission Disequilibrium Test of DRD4 Exon III 48bp Variant Number Tandem Repeat Polymorphism and Tic Disorder]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 19, no. 2, 2002, pp. 100-3.
Huang Y, Liu X, Li T, et al. [Transmission disequilibrium test of DRD4 exon III 48bp variant number tandem repeat polymorphism and tic disorder]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002;19(2):100-3.
Huang, Y., Liu, X., Li, T., Guo, L., Ma, X., Yuan, G., & Peng, R. (2002). [Transmission disequilibrium test of DRD4 exon III 48bp variant number tandem repeat polymorphism and tic disorder]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 19(2), 100-3.
Huang Y, et al. [Transmission Disequilibrium Test of DRD4 Exon III 48bp Variant Number Tandem Repeat Polymorphism and Tic Disorder]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002;19(2):100-3. PubMed PMID: 11941581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Transmission disequilibrium test of DRD4 exon III 48bp variant number tandem repeat polymorphism and tic disorder]. AU - Huang,Yi, AU - Liu,Xiehe, AU - Li,Tao, AU - Guo,Lanting, AU - Ma,Xiaohong, AU - Yuan,Guanggu, AU - Peng,Rong, PY - 2002/4/10/pubmed PY - 2002/5/30/medline PY - 2002/4/10/entrez SP - 100 EP - 3 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 19 IS - 2 N2 - OBJECTIVE: To investigate whether DRD4 exon III48 bp variant number tandem repeat(VNTR) polymorphism is associated with tic disorder. METHODS: One hundred and twenty-two nucleus families were collected using Structured clinical interview for genetic study of Tourette syndrome and related disorders for family-based association analysis of tic disorder and DRD4 exon III 48bp VNTR polymorphism. One hundred and twenty-two trios were divided into two groups: tic disorder group (82 trios of Tourette syndrome or chronic tic disorder, TS&CT) and tic disorder accompanied with attention deficit and hyperactivity disorder (ADHD) group (40 trios of Tourette syndrome or chronic tic disorder accompanied with ADHD, TS&ADHD). Transmission disequilibrium test (TDT), in addition to polymerase chain reaction and VNTR technique were conducted in 122 trios. RESULTS: There exist 5 alleles at this polymorphic locus in this sample including DRD4 exon III 48bp 2-6 repeats. No transmission disequilibrium was found between DRD4 exon III 48 bp VNTR and tic disorder (chi square=7.44, P 0.12); however, when the sample was divided into two groups, transmission disequilibrium was noticed between the cases of TS&ADHD and this locus by overall allele-wise analysis (chi square=11.74, P 0.02), and there exists transmission disequilibrium exclusively between 5 or 6 repeats of 48bp VNTR(longer alleles) by allele-wise analysis (chi square=10.57, P 0.032, chi square=6.13, P 0.01). No transmission disequilibrium was seen between TS&CT and DRD4 exon III 48bp VNTR(chi square=3.38, P 0.50). CONCLUSION: The results of this study have revealed an association between the longer alleles of DRD4 exon III 48bp VNTR polymorphism and tic disorder accompanied with ADHD, thus suggesting a possible genetic risk factor of tic disorder accompanied with ADHD in Chinese. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/11941581/[Transmission_disequilibrium_test_of_DRD4_exon_III_48bp_variant_number_tandem_repeat_polymorphism_and_tic_disorder]_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:11941581 DB - PRIME DP - Unbound Medicine ER -