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Overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia.
Obes Res. 2002 Apr; 10(4):253-9.OR

Abstract

OBJECTIVE

To evaluate the influence of overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia.

RESEARCH METHODS AND PROCEDURES

A cross-sectional study was carried out in a population of 197 subjects: 59 men (21 aged < 60 years and 38 aged > or =60 years) and 138 women (37 aged < 60 years and 101 aged > or =60 years). The groups were stratified by overweight and normal weight. After a 12-hour fasting period, we measured serum leptin and insulin levels with radioimmunoassay methods. We also measured serum glucose and lipid profile. The data were analyzed by means of comparative tests. A variance-stabilizing transformation (natural logarithmic) was used to meet multiple linear regression, analysis of covariance, and logistic regression models.

RESULTS

The leptin serum levels were higher and statistically significant in young and older women than they were in men. We observed an interaction between gender and body mass index to explain the difference in leptin levels (p < 0.0001). Our study demonstrated an inverse relationship between leptin with age and high-density lipoprotein cholesterol. In logistic regression analysis, the overweight x gender interaction and waist circumference have a statistically significant influence as independent variables on hyperleptinemia (overweight x gender odds ratio = 6.81; 95% confidence interval, 1.10 to 46.86; p < 0.05 and waist circumference odds ratio = 4.34; 95% confidence interval, 1.47 to 12.83; p = 0.001).

DISCUSSION

Women who were overweight or had a higher waist circumference (women > or = 88 cm and men > or = 102 cm) have a significantly higher risk of having hyperleptinemia. The increase in age as an isolated variable is not a risk factor for hyperleptinemia.

Authors+Show Affiliations

Unidad de Investigación en Gerontología, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico. mendovic@servidor.unam.mxNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11943833

Citation

Mendoza-Núñez, Víctor Manuel, et al. "Overweight, Waist Circumference, Age, Gender, and Insulin Resistance as Risk Factors for Hyperleptinemia." Obesity Research, vol. 10, no. 4, 2002, pp. 253-9.
Mendoza-Núñez VM, García-Sánchez A, Sánchez-Rodríguez M, et al. Overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia. Obes Res. 2002;10(4):253-9.
Mendoza-Núñez, V. M., García-Sánchez, A., Sánchez-Rodríguez, M., Galván-Duarte, R. E., & Fonseca-Yerena, M. E. (2002). Overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia. Obesity Research, 10(4), 253-9.
Mendoza-Núñez VM, et al. Overweight, Waist Circumference, Age, Gender, and Insulin Resistance as Risk Factors for Hyperleptinemia. Obes Res. 2002;10(4):253-9. PubMed PMID: 11943833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia. AU - Mendoza-Núñez,Víctor Manuel, AU - García-Sánchez,Angel, AU - Sánchez-Rodríguez,Martha, AU - Galván-Duarte,Rosa Elba, AU - Fonseca-Yerena,María Eugenia, PY - 2002/4/12/pubmed PY - 2002/5/9/medline PY - 2002/4/12/entrez SP - 253 EP - 9 JF - Obesity research JO - Obes Res VL - 10 IS - 4 N2 - OBJECTIVE: To evaluate the influence of overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia. RESEARCH METHODS AND PROCEDURES: A cross-sectional study was carried out in a population of 197 subjects: 59 men (21 aged < 60 years and 38 aged > or =60 years) and 138 women (37 aged < 60 years and 101 aged > or =60 years). The groups were stratified by overweight and normal weight. After a 12-hour fasting period, we measured serum leptin and insulin levels with radioimmunoassay methods. We also measured serum glucose and lipid profile. The data were analyzed by means of comparative tests. A variance-stabilizing transformation (natural logarithmic) was used to meet multiple linear regression, analysis of covariance, and logistic regression models. RESULTS: The leptin serum levels were higher and statistically significant in young and older women than they were in men. We observed an interaction between gender and body mass index to explain the difference in leptin levels (p < 0.0001). Our study demonstrated an inverse relationship between leptin with age and high-density lipoprotein cholesterol. In logistic regression analysis, the overweight x gender interaction and waist circumference have a statistically significant influence as independent variables on hyperleptinemia (overweight x gender odds ratio = 6.81; 95% confidence interval, 1.10 to 46.86; p < 0.05 and waist circumference odds ratio = 4.34; 95% confidence interval, 1.47 to 12.83; p = 0.001). DISCUSSION: Women who were overweight or had a higher waist circumference (women > or = 88 cm and men > or = 102 cm) have a significantly higher risk of having hyperleptinemia. The increase in age as an isolated variable is not a risk factor for hyperleptinemia. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/11943833/Overweight_waist_circumference_age_gender_and_insulin_resistance_as_risk_factors_for_hyperleptinemia_ L2 - https://doi.org/10.1038/oby.2002.34 DB - PRIME DP - Unbound Medicine ER -