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Genotype associations of factor VII gene with plasma factor VII coagulant activity and antigen levels in healthy Chinese.
Blood Coagul Fibrinolysis. 2002 Apr; 13(3):217-24.BC

Abstract

A raised plasma factor VII (FVII) level is one of the risk factors for coronary artery disease. The R353Q polymorphism at codon 353 and the 10 base pair (bp) insertion (0/10 bp) polymorphism of the FVII gene have been reported to be associated with plasma FVII levels in several populations. We investigated these two polymorphisms in 209 male and 214 female healthy Chinese. The allele frequencies of 10 bp and Q were 0.036 and 0.045, respectively. Strong linkage disequilibrium was observed between these two sites (Delta = 0.85, P < 0.001). There were significant genotype associations of these two loci with FVII coagulant activity (FVIIc) and antigen (FVIIAg) levels. Heterozygous individuals had lower FVIIc and FVIIAg levels than those homozygous for the common alleles. When analyzed separately by gender, the 0/10 bp polymorphism was strongly associated with FVIIAg levels in males and females. However, both polymorphisms were significantly associated with FVIIc levels only in the females. The effect of 0/10 bp polymorphism predominated over that of the R353Q polymorphism in a two-way analysis of variance procedure. In the Chinese, the 10 bp insertion may reduce transcription of the FVII gene, leading to the decreased synthesis of FVII protein and thus FVIIc.

Authors+Show Affiliations

Department of Paediatrics, National University of Singapore, Singapore. gcslyq@sgh.com.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11943935

Citation

Liu, Y, et al. "Genotype Associations of Factor VII Gene With Plasma Factor VII Coagulant Activity and Antigen Levels in Healthy Chinese." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 13, no. 3, 2002, pp. 217-24.
Liu Y, Heng CK, Saha N, et al. Genotype associations of factor VII gene with plasma factor VII coagulant activity and antigen levels in healthy Chinese. Blood Coagul Fibrinolysis. 2002;13(3):217-24.
Liu, Y., Heng, C. K., Saha, N., Hong, S., & Low, P. S. (2002). Genotype associations of factor VII gene with plasma factor VII coagulant activity and antigen levels in healthy Chinese. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 13(3), 217-24.
Liu Y, et al. Genotype Associations of Factor VII Gene With Plasma Factor VII Coagulant Activity and Antigen Levels in Healthy Chinese. Blood Coagul Fibrinolysis. 2002;13(3):217-24. PubMed PMID: 11943935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genotype associations of factor VII gene with plasma factor VII coagulant activity and antigen levels in healthy Chinese. AU - Liu,Y, AU - Heng,C K, AU - Saha,N, AU - Hong,S, AU - Low,P S, PY - 2002/4/11/pubmed PY - 2002/10/9/medline PY - 2002/4/11/entrez SP - 217 EP - 24 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul Fibrinolysis VL - 13 IS - 3 N2 - A raised plasma factor VII (FVII) level is one of the risk factors for coronary artery disease. The R353Q polymorphism at codon 353 and the 10 base pair (bp) insertion (0/10 bp) polymorphism of the FVII gene have been reported to be associated with plasma FVII levels in several populations. We investigated these two polymorphisms in 209 male and 214 female healthy Chinese. The allele frequencies of 10 bp and Q were 0.036 and 0.045, respectively. Strong linkage disequilibrium was observed between these two sites (Delta = 0.85, P < 0.001). There were significant genotype associations of these two loci with FVII coagulant activity (FVIIc) and antigen (FVIIAg) levels. Heterozygous individuals had lower FVIIc and FVIIAg levels than those homozygous for the common alleles. When analyzed separately by gender, the 0/10 bp polymorphism was strongly associated with FVIIAg levels in males and females. However, both polymorphisms were significantly associated with FVIIc levels only in the females. The effect of 0/10 bp polymorphism predominated over that of the R353Q polymorphism in a two-way analysis of variance procedure. In the Chinese, the 10 bp insertion may reduce transcription of the FVII gene, leading to the decreased synthesis of FVII protein and thus FVIIc. SN - 0957-5235 UR - https://www.unboundmedicine.com/medline/citation/11943935/Genotype_associations_of_factor_VII_gene_with_plasma_factor_VII_coagulant_activity_and_antigen_levels_in_healthy_Chinese_ L2 - https://doi.org/10.1097/00001721-200204000-00007 DB - PRIME DP - Unbound Medicine ER -