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Urinary stone risk factors in the siblings of patients with calcium renal stones.
J Urol. 2002 May; 167(5):1965-7.JU

Abstract

PURPOSE

We determined which, if any, urinary stone risk factors accurately discriminate stone forming and nonstone forming siblings of patients with calcium renal stones.

MATERIALS AND METHODS

A total of 252 siblings of stone formers provided 2, 24-hour urine samples, which were sent overnight and analyzed at a central laboratory. Standard stone risk factors were measured and the supersaturation of calcium oxalate, calcium phosphate and uric acid was calculated.

RESULTS

Discriminant functions were derived for each gender by multivariate analysis. In stone forming sisters higher urinary calcium and pH discriminated with a success rate of 70%. In stone forming brothers higher urinary calcium, lower urinary potassium and older age discriminated with a success rate of 79%.

CONCLUSIONS

Select urinary measurements as well as age classify siblings into those with and without stones with fair accuracy. Calcium excretion and urinary pH in females, and calcium excretion, urinary potassium and age in males are feasible identifiers of stone forming siblings. To determine whether these measurements can be used to predict new stone onset may require years of observation of our current cohort.

Authors+Show Affiliations

Litholink Corp. and Nephrology Section, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11956418

Citation

Kinder, Jennifer M., et al. "Urinary Stone Risk Factors in the Siblings of Patients With Calcium Renal Stones." The Journal of Urology, vol. 167, no. 5, 2002, pp. 1965-7.
Kinder JM, Clark CD, Coe BJ, et al. Urinary stone risk factors in the siblings of patients with calcium renal stones. J Urol. 2002;167(5):1965-7.
Kinder, J. M., Clark, C. D., Coe, B. J., Asplin, J. R., Parks, J. H., & Coe, F. L. (2002). Urinary stone risk factors in the siblings of patients with calcium renal stones. The Journal of Urology, 167(5), 1965-7.
Kinder JM, et al. Urinary Stone Risk Factors in the Siblings of Patients With Calcium Renal Stones. J Urol. 2002;167(5):1965-7. PubMed PMID: 11956418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary stone risk factors in the siblings of patients with calcium renal stones. AU - Kinder,Jennifer M, AU - Clark,Cyndi D, AU - Coe,Brian J, AU - Asplin,John R, AU - Parks,Joan H, AU - Coe,Fredric L, PY - 2002/4/17/pubmed PY - 2002/5/1/medline PY - 2002/4/17/entrez SP - 1965 EP - 7 JF - The Journal of urology JO - J Urol VL - 167 IS - 5 N2 - PURPOSE: We determined which, if any, urinary stone risk factors accurately discriminate stone forming and nonstone forming siblings of patients with calcium renal stones. MATERIALS AND METHODS: A total of 252 siblings of stone formers provided 2, 24-hour urine samples, which were sent overnight and analyzed at a central laboratory. Standard stone risk factors were measured and the supersaturation of calcium oxalate, calcium phosphate and uric acid was calculated. RESULTS: Discriminant functions were derived for each gender by multivariate analysis. In stone forming sisters higher urinary calcium and pH discriminated with a success rate of 70%. In stone forming brothers higher urinary calcium, lower urinary potassium and older age discriminated with a success rate of 79%. CONCLUSIONS: Select urinary measurements as well as age classify siblings into those with and without stones with fair accuracy. Calcium excretion and urinary pH in females, and calcium excretion, urinary potassium and age in males are feasible identifiers of stone forming siblings. To determine whether these measurements can be used to predict new stone onset may require years of observation of our current cohort. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/11956418/Urinary_stone_risk_factors_in_the_siblings_of_patients_with_calcium_renal_stones_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5347(05)65063-X DB - PRIME DP - Unbound Medicine ER -