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[Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats].
Sheng Li Xue Bao. 2000 Jun; 52(3):235-8.SL

Abstract

Fos immunocytochemistry, NADPH-d histochemistry and Fos/NADPH-d double-labeling method were used to study the changes in formalin-induced Fos, NADPH-d positive and Fos/NADPH-d double-labeled neurons in the spinal cord of morphine-tolerant rats. Formalin-induced Fos-like immunoreactivity (Fos-LI) was located in the superficial laminae and neck of ipsilateral spinal cord. Acute administration of morphine decreased the expression of Fos-LI in non-tolerant rats, while the expression of Fos-LI was significantly increased in morphine-tolerant rats. Fos-LI was distributed not only in the whole laminae of the ipsilateral spinal cord but also in the contralateral spinal cord. Acute administration of morphine was ineffective in decreasing the expression of Fos-LI in morphine-tolerant rats. Morphine tolerance increased the expression of formalin-induced NADPH-d positive neurons in the superficial laminae of spinal dorsal horn. A few formalin-induced Fos/NADPH-d double-labeled neurons were detected in the superficial laminae of spinal dorsal horn of non-tolerant rats. In morphine-tolerant rats, on the other hand, formalin-induced Fos/NADPH-d double-labeled neurons were increased and distributed in the whole laminae of the ipsilateral spinal cord and the contralateral superficial spinal cord. It is suggested that NO is involved in the increase of formalin-induced Fos-LI in the spinal cord of morphine-tolerant rats and may play an important role in the development of morphine tolerance.

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Authors+Show Affiliations

Cao JL
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, China.
Zeng YM
No affiliation info available
Zhang LC
No affiliation info available
Duan SM
No affiliation info available

MeSH

AnimalsDrug ToleranceFormaldehydeMaleMorphineNADPH DehydrogenaseNeuronsNitric Oxide SynthaseNitric Oxide Synthase Type IPainProto-Oncogene Proteins c-fosRandom AllocationRatsRats, Sprague-DawleySpinal Cord

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

11956571

Citation

Cao, J L., et al. "[Increased Expression of Formalin-induced Fos and NADPH-d Positive Neurons in the Spinal Cord of Morphine-tolerant Rats]." Sheng Li Xue Bao : [Acta Physiologica Sinica], vol. 52, no. 3, 2000, pp. 235-8.
Cao JL, Zeng YM, Zhang LC, et al. [Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats]. Sheng Li Xue Bao. 2000;52(3):235-8.
Cao, J. L., Zeng, Y. M., Zhang, L. C., & Duan, S. M. (2000). [Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats]. Sheng Li Xue Bao : [Acta Physiologica Sinica], 52(3), 235-8.
Cao JL, et al. [Increased Expression of Formalin-induced Fos and NADPH-d Positive Neurons in the Spinal Cord of Morphine-tolerant Rats]. Sheng Li Xue Bao. 2000;52(3):235-8. PubMed PMID: 11956571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats]. AU - Cao,J L, AU - Zeng,Y M, AU - Zhang,L C, AU - Duan,S M, PY - 2002/4/17/pubmed PY - 2002/12/27/medline PY - 2002/4/17/entrez SP - 235 EP - 8 JF - Sheng li xue bao : [Acta physiologica Sinica] JO - Sheng Li Xue Bao VL - 52 IS - 3 N2 - Fos immunocytochemistry, NADPH-d histochemistry and Fos/NADPH-d double-labeling method were used to study the changes in formalin-induced Fos, NADPH-d positive and Fos/NADPH-d double-labeled neurons in the spinal cord of morphine-tolerant rats. Formalin-induced Fos-like immunoreactivity (Fos-LI) was located in the superficial laminae and neck of ipsilateral spinal cord. Acute administration of morphine decreased the expression of Fos-LI in non-tolerant rats, while the expression of Fos-LI was significantly increased in morphine-tolerant rats. Fos-LI was distributed not only in the whole laminae of the ipsilateral spinal cord but also in the contralateral spinal cord. Acute administration of morphine was ineffective in decreasing the expression of Fos-LI in morphine-tolerant rats. Morphine tolerance increased the expression of formalin-induced NADPH-d positive neurons in the superficial laminae of spinal dorsal horn. A few formalin-induced Fos/NADPH-d double-labeled neurons were detected in the superficial laminae of spinal dorsal horn of non-tolerant rats. In morphine-tolerant rats, on the other hand, formalin-induced Fos/NADPH-d double-labeled neurons were increased and distributed in the whole laminae of the ipsilateral spinal cord and the contralateral superficial spinal cord. It is suggested that NO is involved in the increase of formalin-induced Fos-LI in the spinal cord of morphine-tolerant rats and may play an important role in the development of morphine tolerance. SN - 0371-0874 UR - https://www.unboundmedicine.com/medline/citation/11956571/[Increased_expression_of_formalin_induced_Fos_and_NADPH_d_positive_neurons_in_the_spinal_cord_of_morphine_tolerant_rats]_ L2 - http://www.actaps.com.cn/paper/200003/article/2000-3-13.pdf DB - PRIME DP - Unbound Medicine ER -