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Cytogenetic and molecular analyses of multiple endocrine neoplasias of the MEN1 syndrome.
Int J Oncol. 2002 May; 20(5):971-6.IJ

Abstract

A pancreas carcinoid, an adrenocortical adenoma, three parathyroid adenomas and a parathyroid hyperplasia of 5 MEN1 patients were used for loss of heterozygosity (LOH) and comparative genomic hybridization (CGH) studies. The MEN1 gene is located in the region 11q13, approximately 30 kb distal to PGYM. Four tumors showed LOH on chromosome 11q13 (D11S11335, PGYM, D11S1883, FGF3, D11S937) however LOH was also found beyond 11q13. The pancreas carcinoid and adrenocortical adenoma, both from the same patient, showed LOH at marker 11q23.3 and 11q25. In the three parathyroid adenomas LOH was detected in five different markers: 11q21, 11q22.3, 11q23.2, 11q23.3 and 11q25. No LOH was found in parathyroid hyperplasia. CGH analysis showed in case of the pancreas carcinoid losses on chromosomes 1p, 2q, 3, 6, 9p, 11 and 12p. Gains were found at 4, 5, 7, 8, 13, 14, 15q, 18, 19. The parathyroid adenoma of the third patient showed losses only on chromosome 11 in the region 11p12-p15 and 11q12-q23. Our data indicate that other genes are involved in the tumorigenesis of the MEN1 syndrome. Especially the numerous allelic losses between markers 11q23 and 11q25 (D11S938 and D11S910) are a hint for further tumor suppressor genes on chromosome 11.

Authors+Show Affiliations

Department of Pathophysiology, Karl-Franzens University Graz, A-8010 Graz, Austria.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11956591

Citation

Pourani, Jamile, et al. "Cytogenetic and Molecular Analyses of Multiple Endocrine Neoplasias of the MEN1 Syndrome." International Journal of Oncology, vol. 20, no. 5, 2002, pp. 971-6.
Pourani J, Kaserer K, Pfragner R. Cytogenetic and molecular analyses of multiple endocrine neoplasias of the MEN1 syndrome. Int J Oncol. 2002;20(5):971-6.
Pourani, J., Kaserer, K., & Pfragner, R. (2002). Cytogenetic and molecular analyses of multiple endocrine neoplasias of the MEN1 syndrome. International Journal of Oncology, 20(5), 971-6.
Pourani J, Kaserer K, Pfragner R. Cytogenetic and Molecular Analyses of Multiple Endocrine Neoplasias of the MEN1 Syndrome. Int J Oncol. 2002;20(5):971-6. PubMed PMID: 11956591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytogenetic and molecular analyses of multiple endocrine neoplasias of the MEN1 syndrome. AU - Pourani,Jamile, AU - Kaserer,Klaus, AU - Pfragner,Roswitha, PY - 2002/4/17/pubmed PY - 2002/9/18/medline PY - 2002/4/17/entrez SP - 971 EP - 6 JF - International journal of oncology JO - Int J Oncol VL - 20 IS - 5 N2 - A pancreas carcinoid, an adrenocortical adenoma, three parathyroid adenomas and a parathyroid hyperplasia of 5 MEN1 patients were used for loss of heterozygosity (LOH) and comparative genomic hybridization (CGH) studies. The MEN1 gene is located in the region 11q13, approximately 30 kb distal to PGYM. Four tumors showed LOH on chromosome 11q13 (D11S11335, PGYM, D11S1883, FGF3, D11S937) however LOH was also found beyond 11q13. The pancreas carcinoid and adrenocortical adenoma, both from the same patient, showed LOH at marker 11q23.3 and 11q25. In the three parathyroid adenomas LOH was detected in five different markers: 11q21, 11q22.3, 11q23.2, 11q23.3 and 11q25. No LOH was found in parathyroid hyperplasia. CGH analysis showed in case of the pancreas carcinoid losses on chromosomes 1p, 2q, 3, 6, 9p, 11 and 12p. Gains were found at 4, 5, 7, 8, 13, 14, 15q, 18, 19. The parathyroid adenoma of the third patient showed losses only on chromosome 11 in the region 11p12-p15 and 11q12-q23. Our data indicate that other genes are involved in the tumorigenesis of the MEN1 syndrome. Especially the numerous allelic losses between markers 11q23 and 11q25 (D11S938 and D11S910) are a hint for further tumor suppressor genes on chromosome 11. SN - 1019-6439 UR - https://www.unboundmedicine.com/medline/citation/11956591/Cytogenetic_and_molecular_analyses_of_multiple_endocrine_neoplasias_of_the_MEN1_syndrome_ L2 - http://www.spandidos-publications.com/ijo/20/5/971 DB - PRIME DP - Unbound Medicine ER -