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Lipoprotein responses to weight loss and weight maintenance in high-risk obese subjects.
Eur J Clin Nutr. 2002 Mar; 56(3):264-70.EJ

Abstract

OBJECTIVE

To examine changes in plasma lipids and lipoproteins after 51 months of reduced energy intake and sustained weight loss.

METHODS

One-hundred patients were randomized to one of two dietary interventions for 3 months (weight loss period). Groups A and B received an energy-restricted diet plan of 5.2-6.3 MJ/day but group B was further instructed to replace two of three meals with a nutrient-fortified liquid meal replacement (MR). Upon completion of the weight loss period, all patients were given the same instructions regarding energy intake and were advised to use one MR daily. Body weight and 7 day food diaries were measured monthly or bimonthly and blood lipids at baseline, 3, 9 and 51 months.

RESULTS

Of the original 100 patients 75 had completed 4 y. Of those 75, 73 had complete lipid records. Baseline body weights of Groups A and B were 90.7+/-14.0 and 91.6+/-9.8 kg, respectively. The percentage change in total cholesterol (%DeltaTC) decreased in a linear fashion with increasing weight loss, when all data was combined, but did not approach statistical significance (P< or =0.26, r=0.02). Further regression analysis found a significant negative linear relationship (P< or =0.0001, r=0.69) between initial total cholesterol (TC) concentrations and %DeltaTC. Hence, data from 27 of the 73 completers who exhibited an elevated serum total cholesterol (> or =6.2 mmol/l) were isolated and analyzed further. Baseline TC was 6.75+/-0.64, 5.85+/-0.63 at 9 months (P<0.05) and 5.76+/-0.52 mmol/l at 51 months (P<0.05). Similar values for VLDL-cholesterol were 1.33+/-0.80, 0.74+/-0.24 and 0.66+/-0.21 mmol/l by 51 months (P<0.05). Weight decreased by 5.2+/-5.1, 7.6+/-4.9 and 6.7+/-4.6% at 3, 9 and 51 months, respectively.

CONCLUSION

Continuous energy restriction associated with a clinically meaningful weight loss significantly improved the lipid profile of high-risk patients. Similar weight and diet changes occurring in patients with normal plasma cholesterol were either increased or without affect.

Authors+Show Affiliations

Department of Medicine, University Ulm, Germany. herwig.ditschuneit@medizin.uni-ulm.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11960302

Citation

Ditschuneit, H H., et al. "Lipoprotein Responses to Weight Loss and Weight Maintenance in High-risk Obese Subjects." European Journal of Clinical Nutrition, vol. 56, no. 3, 2002, pp. 264-70.
Ditschuneit HH, Frier HI, Flechtner-Mors M. Lipoprotein responses to weight loss and weight maintenance in high-risk obese subjects. Eur J Clin Nutr. 2002;56(3):264-70.
Ditschuneit, H. H., Frier, H. I., & Flechtner-Mors, M. (2002). Lipoprotein responses to weight loss and weight maintenance in high-risk obese subjects. European Journal of Clinical Nutrition, 56(3), 264-70.
Ditschuneit HH, Frier HI, Flechtner-Mors M. Lipoprotein Responses to Weight Loss and Weight Maintenance in High-risk Obese Subjects. Eur J Clin Nutr. 2002;56(3):264-70. PubMed PMID: 11960302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipoprotein responses to weight loss and weight maintenance in high-risk obese subjects. AU - Ditschuneit,H H, AU - Frier,H I, AU - Flechtner-Mors,M, PY - 2001/06/29/received PY - 2001/10/30/revised PY - 2001/10/31/accepted PY - 2002/4/18/pubmed PY - 2002/5/31/medline PY - 2002/4/18/entrez SP - 264 EP - 70 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 56 IS - 3 N2 - OBJECTIVE: To examine changes in plasma lipids and lipoproteins after 51 months of reduced energy intake and sustained weight loss. METHODS: One-hundred patients were randomized to one of two dietary interventions for 3 months (weight loss period). Groups A and B received an energy-restricted diet plan of 5.2-6.3 MJ/day but group B was further instructed to replace two of three meals with a nutrient-fortified liquid meal replacement (MR). Upon completion of the weight loss period, all patients were given the same instructions regarding energy intake and were advised to use one MR daily. Body weight and 7 day food diaries were measured monthly or bimonthly and blood lipids at baseline, 3, 9 and 51 months. RESULTS: Of the original 100 patients 75 had completed 4 y. Of those 75, 73 had complete lipid records. Baseline body weights of Groups A and B were 90.7+/-14.0 and 91.6+/-9.8 kg, respectively. The percentage change in total cholesterol (%DeltaTC) decreased in a linear fashion with increasing weight loss, when all data was combined, but did not approach statistical significance (P< or =0.26, r=0.02). Further regression analysis found a significant negative linear relationship (P< or =0.0001, r=0.69) between initial total cholesterol (TC) concentrations and %DeltaTC. Hence, data from 27 of the 73 completers who exhibited an elevated serum total cholesterol (> or =6.2 mmol/l) were isolated and analyzed further. Baseline TC was 6.75+/-0.64, 5.85+/-0.63 at 9 months (P<0.05) and 5.76+/-0.52 mmol/l at 51 months (P<0.05). Similar values for VLDL-cholesterol were 1.33+/-0.80, 0.74+/-0.24 and 0.66+/-0.21 mmol/l by 51 months (P<0.05). Weight decreased by 5.2+/-5.1, 7.6+/-4.9 and 6.7+/-4.6% at 3, 9 and 51 months, respectively. CONCLUSION: Continuous energy restriction associated with a clinically meaningful weight loss significantly improved the lipid profile of high-risk patients. Similar weight and diet changes occurring in patients with normal plasma cholesterol were either increased or without affect. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/11960302/Lipoprotein_responses_to_weight_loss_and_weight_maintenance_in_high_risk_obese_subjects_ L2 - https://doi.org/10.1038/sj.ejcn.1601375 DB - PRIME DP - Unbound Medicine ER -