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Gastroesophageal reflux, Barrett esophagus, and esophageal cancer: clinical applications.

Abstract

Gastroesophageal reflux disease (GERD), a condition commonly encountered in the primary care setting, is a risk factor for adenocarcinoma of the esophagus. Despite the ubiquity of the complaint, considerable uncertainty exists with respect to several basic questions, including when to perform endoscopy in patients with chronic reflux symptoms and how to address the cancer risk associated with GERD. These clinical vignettes illustrate common clinical questions encountered in caring for patients with GERD, especially as they relate to the issue of cancer risk. Applying data reviewed in the companion article, we propose practical answers to common clinical situations regarding care of patients with reflux. We also present an algorithm for treatment of patients with chronic GERD symptoms.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Digestive Diseases and Nutrition, Center for Esophageal Disease and Swallowing, CB#7080, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599-7080, USA. nshaheen@med.unc.edu

    Source

    JAMA 287:15 2002 Apr 17 pg 1982-6

    MeSH

    Adenocarcinoma
    Adult
    Aged
    Algorithms
    Anti-Ulcer Agents
    Barrett Esophagus
    Chronic Disease
    Enzyme Inhibitors
    Esophageal Neoplasms
    Esophagoscopy
    Female
    Fundoplication
    Gastroesophageal Reflux
    Histamine H2 Antagonists
    Humans
    Male
    Proton Pump Inhibitors
    Risk Factors

    Pub Type(s)

    Case Reports
    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11960541

    Citation

    Shaheen, Nicholas, and David F. Ransohoff. "Gastroesophageal Reflux, Barrett Esophagus, and Esophageal Cancer: Clinical Applications." JAMA, vol. 287, no. 15, 2002, pp. 1982-6.
    Shaheen N, Ransohoff DF. Gastroesophageal reflux, Barrett esophagus, and esophageal cancer: clinical applications. JAMA. 2002;287(15):1982-6.
    Shaheen, N., & Ransohoff, D. F. (2002). Gastroesophageal reflux, Barrett esophagus, and esophageal cancer: clinical applications. JAMA, 287(15), pp. 1982-6.
    Shaheen N, Ransohoff DF. Gastroesophageal Reflux, Barrett Esophagus, and Esophageal Cancer: Clinical Applications. JAMA. 2002 Apr 17;287(15):1982-6. PubMed PMID: 11960541.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gastroesophageal reflux, Barrett esophagus, and esophageal cancer: clinical applications. AU - Shaheen,Nicholas, AU - Ransohoff,David F, PY - 2002/4/19/pubmed PY - 2002/4/26/medline PY - 2002/4/19/entrez SP - 1982 EP - 6 JF - JAMA JO - JAMA VL - 287 IS - 15 N2 - Gastroesophageal reflux disease (GERD), a condition commonly encountered in the primary care setting, is a risk factor for adenocarcinoma of the esophagus. Despite the ubiquity of the complaint, considerable uncertainty exists with respect to several basic questions, including when to perform endoscopy in patients with chronic reflux symptoms and how to address the cancer risk associated with GERD. These clinical vignettes illustrate common clinical questions encountered in caring for patients with GERD, especially as they relate to the issue of cancer risk. Applying data reviewed in the companion article, we propose practical answers to common clinical situations regarding care of patients with reflux. We also present an algorithm for treatment of patients with chronic GERD symptoms. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/11960541/Gastroesophageal_reflux_Barrett_esophagus_and_esophageal_cancer:_clinical_applications_ L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/287/pg/1982 DB - PRIME DP - Unbound Medicine ER -