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The effect of intrathecal gabapentin on mechanical and thermal hyperalgesia in neuropathic rats induced by spinal nerve ligation.
J Korean Med Sci. 2002 Apr; 17(2):225-9.JK

Abstract

Gabapentin decreases the level of glutamate and elevates that of alpha-amino-butyric acid in the central nervous system. Gabapentin was shown to have antinociceptive effects in several facilitated pain models. Intrathecal gabapentin was also known to be effective in reducing mechanical allodynia in animals with neuropathic pain. In this study, we investigated to see whether intrathecal gabapentin produces antihyperalgesic effects on thermal and mechanical hyperalgesia in neuropathic rats and whether its effects are associated with motor impairment. To induce neuropathic pain in Sprague-Dawley rats, left L5 and L6 spinal nerves were ligated. After a week, lumbar catheterization into subarachnoid space was performed. Then, paw withdrawal times to thermal stimuli and vocalization thresholds to paw pressure were determined before and up to 2 hr after intrathecal injection of gabapentin. Also, motor functions including performance times on rota-rod were determined. Intrathecal gabapentin attenuated significantly thermal and mechanical hyperalgesia in neuropathic rats, but did not block thermal and mechanical nociception in sham-operated rats. Intrathecal gabapentin of antihyperalgesic doses inhibited motor coordination performance without evident ambulatory dysfunction. This study demonstrates that intrathecal gabapentin is effective against thermal and mechanical hyperalgesia, in spite of moderate impairment of motor coordination.

Authors+Show Affiliations

Department of Anesthesiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11961308

Citation

Cho, Hyun Sung, et al. "The Effect of Intrathecal Gabapentin On Mechanical and Thermal Hyperalgesia in Neuropathic Rats Induced By Spinal Nerve Ligation." Journal of Korean Medical Science, vol. 17, no. 2, 2002, pp. 225-9.
Cho HS, Kim MH, Choi DH, et al. The effect of intrathecal gabapentin on mechanical and thermal hyperalgesia in neuropathic rats induced by spinal nerve ligation. J Korean Med Sci. 2002;17(2):225-9.
Cho, H. S., Kim, M. H., Choi, D. H., Lee, J. I., Gwak, M. S., & Hahm, T. S. (2002). The effect of intrathecal gabapentin on mechanical and thermal hyperalgesia in neuropathic rats induced by spinal nerve ligation. Journal of Korean Medical Science, 17(2), 225-9.
Cho HS, et al. The Effect of Intrathecal Gabapentin On Mechanical and Thermal Hyperalgesia in Neuropathic Rats Induced By Spinal Nerve Ligation. J Korean Med Sci. 2002;17(2):225-9. PubMed PMID: 11961308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of intrathecal gabapentin on mechanical and thermal hyperalgesia in neuropathic rats induced by spinal nerve ligation. AU - Cho,Hyun Sung, AU - Kim,Myung Hee, AU - Choi,Duck Hwan, AU - Lee,Jung Il, AU - Gwak,Mi Sook, AU - Hahm,Tae Soo, PY - 2002/4/19/pubmed PY - 2002/10/3/medline PY - 2002/4/19/entrez SP - 225 EP - 9 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 17 IS - 2 N2 - Gabapentin decreases the level of glutamate and elevates that of alpha-amino-butyric acid in the central nervous system. Gabapentin was shown to have antinociceptive effects in several facilitated pain models. Intrathecal gabapentin was also known to be effective in reducing mechanical allodynia in animals with neuropathic pain. In this study, we investigated to see whether intrathecal gabapentin produces antihyperalgesic effects on thermal and mechanical hyperalgesia in neuropathic rats and whether its effects are associated with motor impairment. To induce neuropathic pain in Sprague-Dawley rats, left L5 and L6 spinal nerves were ligated. After a week, lumbar catheterization into subarachnoid space was performed. Then, paw withdrawal times to thermal stimuli and vocalization thresholds to paw pressure were determined before and up to 2 hr after intrathecal injection of gabapentin. Also, motor functions including performance times on rota-rod were determined. Intrathecal gabapentin attenuated significantly thermal and mechanical hyperalgesia in neuropathic rats, but did not block thermal and mechanical nociception in sham-operated rats. Intrathecal gabapentin of antihyperalgesic doses inhibited motor coordination performance without evident ambulatory dysfunction. This study demonstrates that intrathecal gabapentin is effective against thermal and mechanical hyperalgesia, in spite of moderate impairment of motor coordination. SN - 1011-8934 UR - https://www.unboundmedicine.com/medline/citation/11961308/The_effect_of_intrathecal_gabapentin_on_mechanical_and_thermal_hyperalgesia_in_neuropathic_rats_induced_by_spinal_nerve_ligation_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2002.17.2.225 DB - PRIME DP - Unbound Medicine ER -