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[Dementia with Lewy bodies].
Tidsskr Nor Laegeforen. 2002 Feb 20; 122(5):525-9.TN

Abstract

BACKGROUND

Some 10%-15% of patients with dementia are diagnosed as dementia with Lewy bodies (DLB), a disorder characterised by the presence of Lewy bodies in the brainstem and cortex.

MATERIAL AND METHODS

Review of pathology, clinical symptoms, pharmacological and nonpharmacological treatment, based on the literature and on personal experience.

RESULTS

Neurochemical findings are marked cortical reduction of acetylcholine and nigrostriatal dopamine deficiency. Key features of the clinical syndrome are dementia, fluctuating consciousness, visual hallucinations and parkinsonism. There are pathological and clinical overlaps between DLB and Alzheimer's disease on the one hand, and between DLB and Parkinson's disease on the other; the relationship between these diseases awaits further elucidation. Clinical consensus criteria for DLB have been published and shown to have high sensitivity and specificity. Fluctuating consciousness may be difficult to detect, but diagnostic instruments exist that may help in the evaluation. Drug treatment of DLB is difficult. Cholinesterase inhibitors have been shown to improve cognition and psychiatric symptoms. Atypical antipsychotics may improve psychosis, but some patients develop severe sensitivity reactions. The effect of antiparkinson agents is unknown.

Authors+Show Affiliations

Alderspsykiatrisk seksjon Rogaland psykiatriske sjukehus Postboks 1163 Hillevåg 4095 Stavanger. daa@post.rps.no

Pub Type(s)

English Abstract
Journal Article
Review

Language

nor

PubMed ID

11961984

Citation

Arsland, Dag. "[Dementia With Lewy Bodies]." Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, vol. 122, no. 5, 2002, pp. 525-9.
Arsland D. [Dementia with Lewy bodies]. Tidsskr Nor Laegeforen. 2002;122(5):525-9.
Arsland, D. (2002). [Dementia with Lewy bodies]. Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, 122(5), 525-9.
Arsland D. [Dementia With Lewy Bodies]. Tidsskr Nor Laegeforen. 2002 Feb 20;122(5):525-9. PubMed PMID: 11961984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Dementia with Lewy bodies]. A1 - Arsland,Dag, PY - 2002/4/19/pubmed PY - 2002/5/1/medline PY - 2002/4/19/entrez SP - 525 EP - 9 JF - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke JO - Tidsskr Nor Laegeforen VL - 122 IS - 5 N2 - BACKGROUND: Some 10%-15% of patients with dementia are diagnosed as dementia with Lewy bodies (DLB), a disorder characterised by the presence of Lewy bodies in the brainstem and cortex. MATERIAL AND METHODS: Review of pathology, clinical symptoms, pharmacological and nonpharmacological treatment, based on the literature and on personal experience. RESULTS: Neurochemical findings are marked cortical reduction of acetylcholine and nigrostriatal dopamine deficiency. Key features of the clinical syndrome are dementia, fluctuating consciousness, visual hallucinations and parkinsonism. There are pathological and clinical overlaps between DLB and Alzheimer's disease on the one hand, and between DLB and Parkinson's disease on the other; the relationship between these diseases awaits further elucidation. Clinical consensus criteria for DLB have been published and shown to have high sensitivity and specificity. Fluctuating consciousness may be difficult to detect, but diagnostic instruments exist that may help in the evaluation. Drug treatment of DLB is difficult. Cholinesterase inhibitors have been shown to improve cognition and psychiatric symptoms. Atypical antipsychotics may improve psychosis, but some patients develop severe sensitivity reactions. The effect of antiparkinson agents is unknown. SN - 0029-2001 UR - https://www.unboundmedicine.com/medline/citation/11961984/[Dementia_with_Lewy_bodies]_ L2 - https://medlineplus.gov/lewybodydementia.html DB - PRIME DP - Unbound Medicine ER -