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Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia.
Nutr Cancer. 2001; 40(2):118-24.NC

Abstract

Weight loss in advanced cancer patients is refractory to conventional nutritional support. This may be due to metabolic changes mediated by proinflammatory cytokines, hormones, and tumor-derived products. We previously showed that a nutritional supplement enriched with fish oil will reverse weight loss in patients with pancreatic cancer cachexia. The present study examines the effect of this supplement on a number of mediators thought to play a role in cancer cachexia. Twenty weight-losing patients with pancreatic cancer were asked to consume a nutritional supplement providing 600 kcal and 2 g of eicosapentaenoic acid per day. At baseline and after 3 wk, patients were weighed and samples were collected to measure serum concentrations of interleukin (IL)-6 and its soluble receptor tumor necrosis factor receptors I and II, cortisol, insulin, and leptin, peripheral blood mononuclear cell production of IL-1 beta, IL-6, and tumor necrosis factor, and urinary excretion of proteolysis inducing factor. After 3 wk of consumption of the fish oil-enriched nutritional supplement, there was a significant fall in production of IL-6 (from median 16.5 to 13.7 ng/ml, P = 0.015), a rise in serum insulin concentration (from 3.3 to 5.0 mU/l, P = 0.0064), a fall in the cortisol-to-insulin ratio (P = 0.0084), and a fall in the proportion of patients excreting proteolysis inducing factor (from 88% to 40%, P = 0.008). These changes occurred in association with weight gain (median 1 kg, P = 0.024). Various mediators of catabolism in cachexia are modulated by administration of a fish oil-enriched nutritional supplement in pancreatic cancer patients. This may account for the reversal of weight loss in patients consuming this supplement.

Authors+Show Affiliations

University Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh EH3 9YW, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11962246

Citation

Barber, M D., et al. "Effect of a Fish Oil-enriched Nutritional Supplement On Metabolic Mediators in Patients With Pancreatic Cancer Cachexia." Nutrition and Cancer, vol. 40, no. 2, 2001, pp. 118-24.
Barber MD, Fearon KC, Tisdale MJ, et al. Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia. Nutr Cancer. 2001;40(2):118-24.
Barber, M. D., Fearon, K. C., Tisdale, M. J., McMillan, D. C., & Ross, J. A. (2001). Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia. Nutrition and Cancer, 40(2), 118-24.
Barber MD, et al. Effect of a Fish Oil-enriched Nutritional Supplement On Metabolic Mediators in Patients With Pancreatic Cancer Cachexia. Nutr Cancer. 2001;40(2):118-24. PubMed PMID: 11962246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a fish oil-enriched nutritional supplement on metabolic mediators in patients with pancreatic cancer cachexia. AU - Barber,M D, AU - Fearon,K C, AU - Tisdale,M J, AU - McMillan,D C, AU - Ross,J A, PY - 2002/4/19/pubmed PY - 2002/10/9/medline PY - 2002/4/19/entrez SP - 118 EP - 24 JF - Nutrition and cancer JO - Nutr Cancer VL - 40 IS - 2 N2 - Weight loss in advanced cancer patients is refractory to conventional nutritional support. This may be due to metabolic changes mediated by proinflammatory cytokines, hormones, and tumor-derived products. We previously showed that a nutritional supplement enriched with fish oil will reverse weight loss in patients with pancreatic cancer cachexia. The present study examines the effect of this supplement on a number of mediators thought to play a role in cancer cachexia. Twenty weight-losing patients with pancreatic cancer were asked to consume a nutritional supplement providing 600 kcal and 2 g of eicosapentaenoic acid per day. At baseline and after 3 wk, patients were weighed and samples were collected to measure serum concentrations of interleukin (IL)-6 and its soluble receptor tumor necrosis factor receptors I and II, cortisol, insulin, and leptin, peripheral blood mononuclear cell production of IL-1 beta, IL-6, and tumor necrosis factor, and urinary excretion of proteolysis inducing factor. After 3 wk of consumption of the fish oil-enriched nutritional supplement, there was a significant fall in production of IL-6 (from median 16.5 to 13.7 ng/ml, P = 0.015), a rise in serum insulin concentration (from 3.3 to 5.0 mU/l, P = 0.0064), a fall in the cortisol-to-insulin ratio (P = 0.0084), and a fall in the proportion of patients excreting proteolysis inducing factor (from 88% to 40%, P = 0.008). These changes occurred in association with weight gain (median 1 kg, P = 0.024). Various mediators of catabolism in cachexia are modulated by administration of a fish oil-enriched nutritional supplement in pancreatic cancer patients. This may account for the reversal of weight loss in patients consuming this supplement. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/11962246/Effect_of_a_fish_oil_enriched_nutritional_supplement_on_metabolic_mediators_in_patients_with_pancreatic_cancer_cachexia_ L2 - https://www.tandfonline.com/doi/full/10.1207/S15327914NC402_7 DB - PRIME DP - Unbound Medicine ER -