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Altered EEG responses to ethanol in adult rats exposed to ethanol during adolescence.
Alcohol Clin Exp Res. 2002 Feb; 26(2):246-54.AC

Abstract

BACKGROUND

Adolescent ethanol (EtOH) exposure is a significant health concern due to the potential long-term effects of EtOH on the developing brain. However, few studies have assessed how exposure to EtOH during adolescence influences the response of adults to EtOH after a long period of withdrawal. This study was designed to assess long-term changes in EEG activity after EtOH challenge in adult rats exposed to EtOH during adolescence.

METHODS

Male Sprague Dawley rats (n = 24) were exposed to EtOH vapor for 5 days (12 hr/day) between postnatal days 35 and 40. After maturing to adulthood, rats were implanted with cortical, amygdalar, and hippocampal electrodes. Then EEG activity after EtOH challenge (0.0-1.5 g/kg) was assessed.

RESULTS

There were no EEG differences between groups under baseline or vehicle conditions, but EtOH did have differential behavioral and electrophysiological effects when adolescent ethanol-exposed rats were compared with controls. After 1.5 g/kg EtOH, ethanol-exposed rats displayed decreased behavioral indexes of intoxication. In addition, EtOH significantly increased 4 to 6 Hz power in the hippocampus and parietal cortex of the control group but had no effect on 4 to 6 Hz power in the ethanol-exposed group in either of these brain regions. EtOH produced maximal increases in cortical EEG variability in control rats after 1.5 g/kg EtOH but produced maximal increases in cortical EEG variability in ethanol-exposed rats after 1.0 g/kg EtOH. As a result, ethanol-induced increases in EEG variability after 1.5 g/kg ethanol were blunted in the ethanol-exposed group compared with the control group.

CONCLUSIONS

These data demonstrate persistent and brain-region-specific changes in the neurobehavioral effects of acute EtOH challenge in adult rats exposed to EtOH during adolescence in the absence of baseline neurophysiological differences. Decreased EEG responses to high doses of EtOH combined with decreased behavioral measures of intoxication suggest that adolescent ethanol exposure produces long-lasting tolerance to the sedative effects of ethanol.

Authors+Show Affiliations

Scripps Research Institute, Department of Neuropharmacology, La Jolla, California 92037, USA. cslawecki@scripps.edu

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11964565

Citation

Slawecki, Craig J.. "Altered EEG Responses to Ethanol in Adult Rats Exposed to Ethanol During Adolescence." Alcoholism, Clinical and Experimental Research, vol. 26, no. 2, 2002, pp. 246-54.
Slawecki CJ. Altered EEG responses to ethanol in adult rats exposed to ethanol during adolescence. Alcohol Clin Exp Res. 2002;26(2):246-54.
Slawecki, C. J. (2002). Altered EEG responses to ethanol in adult rats exposed to ethanol during adolescence. Alcoholism, Clinical and Experimental Research, 26(2), 246-54.
Slawecki CJ. Altered EEG Responses to Ethanol in Adult Rats Exposed to Ethanol During Adolescence. Alcohol Clin Exp Res. 2002;26(2):246-54. PubMed PMID: 11964565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered EEG responses to ethanol in adult rats exposed to ethanol during adolescence. A1 - Slawecki,Craig J, PY - 2002/4/20/pubmed PY - 2002/8/2/medline PY - 2002/4/20/entrez SP - 246 EP - 54 JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. VL - 26 IS - 2 N2 - BACKGROUND: Adolescent ethanol (EtOH) exposure is a significant health concern due to the potential long-term effects of EtOH on the developing brain. However, few studies have assessed how exposure to EtOH during adolescence influences the response of adults to EtOH after a long period of withdrawal. This study was designed to assess long-term changes in EEG activity after EtOH challenge in adult rats exposed to EtOH during adolescence. METHODS: Male Sprague Dawley rats (n = 24) were exposed to EtOH vapor for 5 days (12 hr/day) between postnatal days 35 and 40. After maturing to adulthood, rats were implanted with cortical, amygdalar, and hippocampal electrodes. Then EEG activity after EtOH challenge (0.0-1.5 g/kg) was assessed. RESULTS: There were no EEG differences between groups under baseline or vehicle conditions, but EtOH did have differential behavioral and electrophysiological effects when adolescent ethanol-exposed rats were compared with controls. After 1.5 g/kg EtOH, ethanol-exposed rats displayed decreased behavioral indexes of intoxication. In addition, EtOH significantly increased 4 to 6 Hz power in the hippocampus and parietal cortex of the control group but had no effect on 4 to 6 Hz power in the ethanol-exposed group in either of these brain regions. EtOH produced maximal increases in cortical EEG variability in control rats after 1.5 g/kg EtOH but produced maximal increases in cortical EEG variability in ethanol-exposed rats after 1.0 g/kg EtOH. As a result, ethanol-induced increases in EEG variability after 1.5 g/kg ethanol were blunted in the ethanol-exposed group compared with the control group. CONCLUSIONS: These data demonstrate persistent and brain-region-specific changes in the neurobehavioral effects of acute EtOH challenge in adult rats exposed to EtOH during adolescence in the absence of baseline neurophysiological differences. Decreased EEG responses to high doses of EtOH combined with decreased behavioral measures of intoxication suggest that adolescent ethanol exposure produces long-lasting tolerance to the sedative effects of ethanol. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/11964565/Altered_EEG_responses_to_ethanol_in_adult_rats_exposed_to_ethanol_during_adolescence_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=2002&volume=26&issue=2&spage=246 DB - PRIME DP - Unbound Medicine ER -