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Comparison of the main oesophageal pathophysiological characteristics between short- and long-segment Barrett's oesophagus.
Aliment Pharmacol Ther 2002; 16(5):893-8AP

Abstract

AIM

To assess the oesophageal manometric characteristics and 24-h pH profiles of patients with both short-segment and long-segment Barrett's oesophagus and compare them with those of patients with reflux oesophagitis and controls.

METHODS

Seventy-nine patients who had undergone upper digestive endoscopy were recruited: 16 had short-segment Barrett's oesophagus, 13 had long-segment Barrett's oesophagus, 25 had grade III oesophagitis according to the Savary-Miller classification and 25 were used as controls. The diagnosis of Barrett's oesophagus was based on the histological detection of specialized intestinal metaplasia, which extended < 3 cm into the oesophagus in patients with short-segment disease and > 3 cm in patients with long-segment disease. All subjects underwent oesophageal manometry and basal 24-h oesophageal pH monitoring.

RESULTS

The lower oesophageal sphincter pressure was significantly lower in patients with reflux oesophagitis and short-segment and long-segment Barrett's oesophagus than in controls (P=0.0004-0.0001), but there was no difference among the three reflux groups. The peristaltic wave amplitude of patients with long-segment Barrett's oesophagus was significantly lower than that of controls (P=0.002) and patients with short-segment Barrett's oesophagus (P=0.02), but was no different from that of patients with reflux oesophagitis. The percentage of non-propagated wet swallows was significantly higher in patients with reflux oesophagitis and short-segment and long-segment Barrett's oesophagus when compared with that of controls (P=0.0004-0.0001). The total percentage of time the oesophagus was exposed to pH < 4.0 was significantly higher in patients with reflux oesophagitis and short-segment and long-segment Barrett's oesophagus (P=0.0001) than in controls, and was higher in patients with long-segment disease than in those with short-segment disease (P=0.01).

CONCLUSIONS

Long-segment Barrett's oesophagus is characterized by a greater impairment of peristaltic wave amplitude and a higher oesophageal acid exposure than is short-segment Barrett's oesophagus. However, both forms are linked to increased acid reflux.

Authors+Show Affiliations

Dipartimento di Medicina Interna e Specialità Mediche, Università di Genova, Genova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11966497

Citation

Zentilin, P, et al. "Comparison of the Main Oesophageal Pathophysiological Characteristics Between Short- and Long-segment Barrett's Oesophagus." Alimentary Pharmacology & Therapeutics, vol. 16, no. 5, 2002, pp. 893-8.
Zentilin P, Conio M, Mele MR, et al. Comparison of the main oesophageal pathophysiological characteristics between short- and long-segment Barrett's oesophagus. Aliment Pharmacol Ther. 2002;16(5):893-8.
Zentilin, P., Conio, M., Mele, M. R., Mansi, C., Pandolfo, N., Dulbecco, P., ... Savarino, V. (2002). Comparison of the main oesophageal pathophysiological characteristics between short- and long-segment Barrett's oesophagus. Alimentary Pharmacology & Therapeutics, 16(5), pp. 893-8.
Zentilin P, et al. Comparison of the Main Oesophageal Pathophysiological Characteristics Between Short- and Long-segment Barrett's Oesophagus. Aliment Pharmacol Ther. 2002;16(5):893-8. PubMed PMID: 11966497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the main oesophageal pathophysiological characteristics between short- and long-segment Barrett's oesophagus. AU - Zentilin,P, AU - Conio,M, AU - Mele,M R, AU - Mansi,C, AU - Pandolfo,N, AU - Dulbecco,P, AU - Gambaro,C, AU - Tessieri,L, AU - Iiritano,E, AU - Bilardi,C, AU - Biagini,R, AU - Vigneri,S, AU - Savarino,V, PY - 2002/4/23/pubmed PY - 2002/9/11/medline PY - 2002/4/23/entrez SP - 893 EP - 8 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 16 IS - 5 N2 - AIM: To assess the oesophageal manometric characteristics and 24-h pH profiles of patients with both short-segment and long-segment Barrett's oesophagus and compare them with those of patients with reflux oesophagitis and controls. METHODS: Seventy-nine patients who had undergone upper digestive endoscopy were recruited: 16 had short-segment Barrett's oesophagus, 13 had long-segment Barrett's oesophagus, 25 had grade III oesophagitis according to the Savary-Miller classification and 25 were used as controls. The diagnosis of Barrett's oesophagus was based on the histological detection of specialized intestinal metaplasia, which extended < 3 cm into the oesophagus in patients with short-segment disease and > 3 cm in patients with long-segment disease. All subjects underwent oesophageal manometry and basal 24-h oesophageal pH monitoring. RESULTS: The lower oesophageal sphincter pressure was significantly lower in patients with reflux oesophagitis and short-segment and long-segment Barrett's oesophagus than in controls (P=0.0004-0.0001), but there was no difference among the three reflux groups. The peristaltic wave amplitude of patients with long-segment Barrett's oesophagus was significantly lower than that of controls (P=0.002) and patients with short-segment Barrett's oesophagus (P=0.02), but was no different from that of patients with reflux oesophagitis. The percentage of non-propagated wet swallows was significantly higher in patients with reflux oesophagitis and short-segment and long-segment Barrett's oesophagus when compared with that of controls (P=0.0004-0.0001). The total percentage of time the oesophagus was exposed to pH < 4.0 was significantly higher in patients with reflux oesophagitis and short-segment and long-segment Barrett's oesophagus (P=0.0001) than in controls, and was higher in patients with long-segment disease than in those with short-segment disease (P=0.01). CONCLUSIONS: Long-segment Barrett's oesophagus is characterized by a greater impairment of peristaltic wave amplitude and a higher oesophageal acid exposure than is short-segment Barrett's oesophagus. However, both forms are linked to increased acid reflux. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/11966497/Comparison_of_the_main_oesophageal_pathophysiological_characteristics_between_short__and_long_segment_Barrett's_oesophagus_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=2002&amp;volume=16&amp;issue=5&amp;spage=893 DB - PRIME DP - Unbound Medicine ER -