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Osteoporosis in inflammatory bowel disease: effect of calcium and vitamin D with or without fluoride.
Aliment Pharmacol Ther 2002; 16(5):919-27AP

Abstract

BACKGROUND

Previous data have indicated low bone formation as a mechanism of osteoporosis in inflammatory bowel disease. Fluoride can stimulate bone formation.

AIM

To assess the effect of fluoride supplementation on lumbar spine bone mineral density in osteoporotic patients with inflammatory bowel disease treated in parallel with calcium and vitamin D.

METHODS

In this prospective, randomized, double-blind, parallel and placebo-controlled study, 94 patients with inflammatory bowel disease (lumbar spine T score below - 2 standard deviations, normal serum 25OH vitamin D), with a median age of 35 years, were included. Bone mineral density was measured by dual-energy X-ray absorptiometry. Patients were randomized to receive daily either sodium monofluorophosphate (150 mg, n=45) or placebo (n=49) for 1 year, and all received calcium (1 g) and vitamin D (800 IU). The relative change in bone mineral density from 0 to 12 months was tested in each group (fluoride or placebo) and compared between the groups.

RESULTS

Lumbar spine bone mineral density increased significantly in both groups after 1 year: 4.8 +/- 5.6% (n=29) and 3.2 +/- 3.8% (n=31) in the calcium-vitamin D-fluoride and calcium-vitamin D-placebo groups, respectively (P < 0.001 for each group). There was no difference between the groups (P=0.403). Similar results were observed according to corticosteroid intake or disease activity.

CONCLUSIONS

Calcium and vitamin D seem to increase lumbar spine density in osteoporotic patients with inflammatory bowel disease; fluoride does not provide further benefit.

Authors+Show Affiliations

Service de Gastroentérologie, Hôpital Cochin, Paris, France, INSERM U444, Université de Paris, Paris, France. vered@club-internet.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11966500

Citation

Abitbol, V, et al. "Osteoporosis in Inflammatory Bowel Disease: Effect of Calcium and Vitamin D With or Without Fluoride." Alimentary Pharmacology & Therapeutics, vol. 16, no. 5, 2002, pp. 919-27.
Abitbol V, Mary JY, Roux C, et al. Osteoporosis in inflammatory bowel disease: effect of calcium and vitamin D with or without fluoride. Aliment Pharmacol Ther. 2002;16(5):919-27.
Abitbol, V., Mary, J. Y., Roux, C., Soulé, J. C., Belaiche, J., Dupas, J. L., ... Chaussade, S. (2002). Osteoporosis in inflammatory bowel disease: effect of calcium and vitamin D with or without fluoride. Alimentary Pharmacology & Therapeutics, 16(5), pp. 919-27.
Abitbol V, et al. Osteoporosis in Inflammatory Bowel Disease: Effect of Calcium and Vitamin D With or Without Fluoride. Aliment Pharmacol Ther. 2002;16(5):919-27. PubMed PMID: 11966500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteoporosis in inflammatory bowel disease: effect of calcium and vitamin D with or without fluoride. AU - Abitbol,V, AU - Mary,J Y, AU - Roux,C, AU - Soulé,J C, AU - Belaiche,J, AU - Dupas,J-L, AU - Gendre,J P, AU - Lerebours,E, AU - Chaussade,S, AU - ,, PY - 2002/4/23/pubmed PY - 2002/9/11/medline PY - 2002/4/23/entrez SP - 919 EP - 27 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 16 IS - 5 N2 - BACKGROUND: Previous data have indicated low bone formation as a mechanism of osteoporosis in inflammatory bowel disease. Fluoride can stimulate bone formation. AIM: To assess the effect of fluoride supplementation on lumbar spine bone mineral density in osteoporotic patients with inflammatory bowel disease treated in parallel with calcium and vitamin D. METHODS: In this prospective, randomized, double-blind, parallel and placebo-controlled study, 94 patients with inflammatory bowel disease (lumbar spine T score below - 2 standard deviations, normal serum 25OH vitamin D), with a median age of 35 years, were included. Bone mineral density was measured by dual-energy X-ray absorptiometry. Patients were randomized to receive daily either sodium monofluorophosphate (150 mg, n=45) or placebo (n=49) for 1 year, and all received calcium (1 g) and vitamin D (800 IU). The relative change in bone mineral density from 0 to 12 months was tested in each group (fluoride or placebo) and compared between the groups. RESULTS: Lumbar spine bone mineral density increased significantly in both groups after 1 year: 4.8 +/- 5.6% (n=29) and 3.2 +/- 3.8% (n=31) in the calcium-vitamin D-fluoride and calcium-vitamin D-placebo groups, respectively (P < 0.001 for each group). There was no difference between the groups (P=0.403). Similar results were observed according to corticosteroid intake or disease activity. CONCLUSIONS: Calcium and vitamin D seem to increase lumbar spine density in osteoporotic patients with inflammatory bowel disease; fluoride does not provide further benefit. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/11966500/Osteoporosis_in_inflammatory_bowel_disease:_effect_of_calcium_and_vitamin_D_with_or_without_fluoride_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=2002&amp;volume=16&amp;issue=5&amp;spage=919 DB - PRIME DP - Unbound Medicine ER -