Tags

Type your tag names separated by a space and hit enter

Molecular and genetic defects in colorectal tumorigenesis.
Best Pract Res Clin Gastroenterol. 2002 Apr; 16(2):171-85.BP

Abstract

Colorectal cancers, whether sporadic or hereditary, are caused by a defined set of molecular events. There are at least two different pathogenetic pathways for colorectal cancer: the chromosomal instability pathway and the microsatellite instability pathway; the two major inherited syndromes, familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), are examples of these two mechanisms. These different pathways, however, converge on common pathological entities that have crucial functions in the regulation of normal crypt homeostasis. Preventive strategies aimed at reversing these changes, or therapeutic interventions targeting cell populations with these alterations, should be most efficacious. Genetic testing for inherited syndromes is now available and allows appropriate management of these disorders. Further insight into colorectal tumorigenesis pathways can lead to the development of useful prognostic indicators and target preventive and therapeutic strategies in the management of colorectal cancer.

Authors+Show Affiliations

Center for Human Genetics, University Hospital Gasthuisberg, Leuven, Belgium.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11969232

Citation

Tejpar, Sabine, and Eric Van Cutsem. "Molecular and Genetic Defects in Colorectal Tumorigenesis." Best Practice & Research. Clinical Gastroenterology, vol. 16, no. 2, 2002, pp. 171-85.
Tejpar S, Van Cutsem E. Molecular and genetic defects in colorectal tumorigenesis. Best Pract Res Clin Gastroenterol. 2002;16(2):171-85.
Tejpar, S., & Van Cutsem, E. (2002). Molecular and genetic defects in colorectal tumorigenesis. Best Practice & Research. Clinical Gastroenterology, 16(2), 171-85.
Tejpar S, Van Cutsem E. Molecular and Genetic Defects in Colorectal Tumorigenesis. Best Pract Res Clin Gastroenterol. 2002;16(2):171-85. PubMed PMID: 11969232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular and genetic defects in colorectal tumorigenesis. AU - Tejpar,Sabine, AU - Van Cutsem,Eric, PY - 2002/4/24/pubmed PY - 2002/11/1/medline PY - 2002/4/24/entrez SP - 171 EP - 85 JF - Best practice & research. Clinical gastroenterology JO - Best Pract Res Clin Gastroenterol VL - 16 IS - 2 N2 - Colorectal cancers, whether sporadic or hereditary, are caused by a defined set of molecular events. There are at least two different pathogenetic pathways for colorectal cancer: the chromosomal instability pathway and the microsatellite instability pathway; the two major inherited syndromes, familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), are examples of these two mechanisms. These different pathways, however, converge on common pathological entities that have crucial functions in the regulation of normal crypt homeostasis. Preventive strategies aimed at reversing these changes, or therapeutic interventions targeting cell populations with these alterations, should be most efficacious. Genetic testing for inherited syndromes is now available and allows appropriate management of these disorders. Further insight into colorectal tumorigenesis pathways can lead to the development of useful prognostic indicators and target preventive and therapeutic strategies in the management of colorectal cancer. SN - 1521-6918 UR - https://www.unboundmedicine.com/medline/citation/11969232/Molecular_and_genetic_defects_in_colorectal_tumorigenesis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521691801902793 DB - PRIME DP - Unbound Medicine ER -