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Glucose but not protein or fat load amplifies the cortisol response to psychosocial stress.
Horm Behav. 2002 May; 41(3):328-33.HB

Abstract

We previously reported that glucose intake amplifies cortisol response to psychosocial stress and smoking in healthy young men, while low blood glucose levels prevented the stress-induced activation of the hypothalamus pituitary adrenal (HPA) axis. However, it remains unknown whether this modulation is specific for glucose load or a more common effect of energy availability. To elucidate this question, 37 healthy men, who fasted for at least 8 h before the experiment, were randomly assigned to four experimental groups, who received glucose (n = 8), protein (n = 10), fat (n = 10), and water (n = 9), one h before their exposure to the Trier Social Stress Test (TSST). Blood glucose levels were measured at baseline and following stress, while salivary cortisol was assessed repeatedly measured before after the TSST. The results show that both absolute cortisol levels and net cortisol increase were greater in the glucose group in comparison to the other groups (F(3,33) = 3.00, P < 0.05 and F(3,33) = 3.08, P < 0.05, respectively. No group differences were observed with respect to perceived stress and mood. Furthermore, the cortisol response was positively correlated with blood glucose changes (r = 0.49, P < 0.002). In conclusion, the results suggest a central mechanism responsible for regulation of energy balance and HPA axis activation, rather than peripheral mechanisms. We thus recommend controlling for blood glucose levels when studying HPA axis responsiveness.

Authors+Show Affiliations

Department of Psychology, University of Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11971667

Citation

Gonzalez-Bono, Esperanza, et al. "Glucose but Not Protein or Fat Load Amplifies the Cortisol Response to Psychosocial Stress." Hormones and Behavior, vol. 41, no. 3, 2002, pp. 328-33.
Gonzalez-Bono E, Rohleder N, Hellhammer DH, et al. Glucose but not protein or fat load amplifies the cortisol response to psychosocial stress. Horm Behav. 2002;41(3):328-33.
Gonzalez-Bono, E., Rohleder, N., Hellhammer, D. H., Salvador, A., & Kirschbaum, C. (2002). Glucose but not protein or fat load amplifies the cortisol response to psychosocial stress. Hormones and Behavior, 41(3), 328-33.
Gonzalez-Bono E, et al. Glucose but Not Protein or Fat Load Amplifies the Cortisol Response to Psychosocial Stress. Horm Behav. 2002;41(3):328-33. PubMed PMID: 11971667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucose but not protein or fat load amplifies the cortisol response to psychosocial stress. AU - Gonzalez-Bono,Esperanza, AU - Rohleder,Nicolas, AU - Hellhammer,Dirk H, AU - Salvador,Alicia, AU - Kirschbaum,Clemens, PY - 2002/4/25/pubmed PY - 2002/7/4/medline PY - 2002/4/25/entrez SP - 328 EP - 33 JF - Hormones and behavior JO - Horm Behav VL - 41 IS - 3 N2 - We previously reported that glucose intake amplifies cortisol response to psychosocial stress and smoking in healthy young men, while low blood glucose levels prevented the stress-induced activation of the hypothalamus pituitary adrenal (HPA) axis. However, it remains unknown whether this modulation is specific for glucose load or a more common effect of energy availability. To elucidate this question, 37 healthy men, who fasted for at least 8 h before the experiment, were randomly assigned to four experimental groups, who received glucose (n = 8), protein (n = 10), fat (n = 10), and water (n = 9), one h before their exposure to the Trier Social Stress Test (TSST). Blood glucose levels were measured at baseline and following stress, while salivary cortisol was assessed repeatedly measured before after the TSST. The results show that both absolute cortisol levels and net cortisol increase were greater in the glucose group in comparison to the other groups (F(3,33) = 3.00, P < 0.05 and F(3,33) = 3.08, P < 0.05, respectively. No group differences were observed with respect to perceived stress and mood. Furthermore, the cortisol response was positively correlated with blood glucose changes (r = 0.49, P < 0.002). In conclusion, the results suggest a central mechanism responsible for regulation of energy balance and HPA axis activation, rather than peripheral mechanisms. We thus recommend controlling for blood glucose levels when studying HPA axis responsiveness. SN - 0018-506X UR - https://www.unboundmedicine.com/medline/citation/11971667/Glucose_but_not_protein_or_fat_load_amplifies_the_cortisol_response_to_psychosocial_stress_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0018506X02917666 DB - PRIME DP - Unbound Medicine ER -