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Sympathetic skin response in diabetic neuropathy.
Electromyogr Clin Neurophysiol. 2002 Apr-May; 42(3):181-5.EC

Abstract

Autonomic neuropathy is a complication of diabetes mellitus (DM) in substantial proportion of cases and may cause definite autonomic symptoms. Because conventional electrophysiological methods do not assess the autonomic nervous system, simple reproducible tests were developed. One of them is sympathetic skin response (SSR) which provides useful information about the status of sympathetic postganglionic function. The aim of this study is to perform SSR in diabetic patients to see whether this test can be used as an electrophysiological method for the diagnosis and confirmation of diabetic autonomic neuropathy. 20 diabetic patients who had electrophysiologically confirmed polyneuropathy but showed no symptoms or signs referable to autonomic system dysfunction were included. 14 (70%) patients demonstrated abnormal SSR. 2 abnormal patterns were observed. An absent response in at least one tested lower extremity (50%) and prolonged foot with normal hand latency (20%). 6 patients (30%) demonstrated no abnormalities. Foot and hand latencies in diabetics did not differ significantly from those of normal controls (p: 0.4, p: 0.1) and no correlation could be found with latencies and duration of sickness, patient's age and HbA1c values. We believe latency measurement is an objective measure of conduction in multineural pathways and can detect subclinical involvement of sympathetic nervous system in diabetics who do not manifest symptoms or signs referable to autonomic system dysfunction.

Authors+Show Affiliations

Gazi University, Faculty of Medicine, Department of Neurology.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

11977432

Citation

Nazhel, B, et al. "Sympathetic Skin Response in Diabetic Neuropathy." Electromyography and Clinical Neurophysiology, vol. 42, no. 3, 2002, pp. 181-5.
Nazhel B, Yetkin I, Irkeç C, et al. Sympathetic skin response in diabetic neuropathy. Electromyogr Clin Neurophysiol. 2002;42(3):181-5.
Nazhel, B., Yetkin, I., Irkeç, C., & Koçer, B. (2002). Sympathetic skin response in diabetic neuropathy. Electromyography and Clinical Neurophysiology, 42(3), 181-5.
Nazhel B, et al. Sympathetic Skin Response in Diabetic Neuropathy. Electromyogr Clin Neurophysiol. 2002 Apr-May;42(3):181-5. PubMed PMID: 11977432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sympathetic skin response in diabetic neuropathy. AU - Nazhel,B, AU - Yetkin,I, AU - Irkeç,C, AU - Koçer,B, PY - 2002/4/30/pubmed PY - 2002/9/21/medline PY - 2002/4/30/entrez SP - 181 EP - 5 JF - Electromyography and clinical neurophysiology JO - Electromyogr Clin Neurophysiol VL - 42 IS - 3 N2 - Autonomic neuropathy is a complication of diabetes mellitus (DM) in substantial proportion of cases and may cause definite autonomic symptoms. Because conventional electrophysiological methods do not assess the autonomic nervous system, simple reproducible tests were developed. One of them is sympathetic skin response (SSR) which provides useful information about the status of sympathetic postganglionic function. The aim of this study is to perform SSR in diabetic patients to see whether this test can be used as an electrophysiological method for the diagnosis and confirmation of diabetic autonomic neuropathy. 20 diabetic patients who had electrophysiologically confirmed polyneuropathy but showed no symptoms or signs referable to autonomic system dysfunction were included. 14 (70%) patients demonstrated abnormal SSR. 2 abnormal patterns were observed. An absent response in at least one tested lower extremity (50%) and prolonged foot with normal hand latency (20%). 6 patients (30%) demonstrated no abnormalities. Foot and hand latencies in diabetics did not differ significantly from those of normal controls (p: 0.4, p: 0.1) and no correlation could be found with latencies and duration of sickness, patient's age and HbA1c values. We believe latency measurement is an objective measure of conduction in multineural pathways and can detect subclinical involvement of sympathetic nervous system in diabetics who do not manifest symptoms or signs referable to autonomic system dysfunction. SN - 0301-150X UR - https://www.unboundmedicine.com/medline/citation/11977432/Sympathetic_skin_response_in_diabetic_neuropathy_ L2 - https://medlineplus.gov/diabeticnerveproblems.html DB - PRIME DP - Unbound Medicine ER -