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[The preventive effect of allopurinol spray on stomatitis induced by anti-cancer drugs].
Gan To Kagaku Ryoho. 2002 Apr; 29(4):563-7.GT

Abstract

The present study was conducted to evaluate the effect of allopurinol spray on stomatitis induced by chemotherapy for esophageal cancer. The chemotherapeutics used consisted of 5-FU + CDDP (FC) given to 40 patients and 5-FU + ND (FN) given to 9 patients. Allopurinol solution for spray was prepared using a gelatin agent as base. The allopurinol spray was used 3-5 times daily before and after chemotherapy. The Japan Society for Cancer Therapy's criteria for stomatitis were used. With FN-therapy, no stomatitis was observed. With FC-therapy, 9 of 40 patients developed stomatitis of grade 1 (8 patients) or grade 2 (1). The incidence of stomatitis was 18.4% with all therapies and 22.5% with FC-therapy. The average graded toxicity was 0.20 for all therapies and 0.25 for FC-therapy. These results suggest that allopurinol spray is markedly effective for the prevention of stomatitis induced by chemotherapy. In addition, allopurinol spray is portable and convenient, and resulted in less nausea or vomiting than mouthwash.

Authors+Show Affiliations

Dept. of Pharmacy, Tokyo Women's Medical University.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

jpn

PubMed ID

11977540

Citation

Ito, Akihiko, et al. "[The Preventive Effect of Allopurinol Spray On Stomatitis Induced By Anti-cancer Drugs]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 29, no. 4, 2002, pp. 563-7.
Ito A, Hanawa T, Fujii E. [The preventive effect of allopurinol spray on stomatitis induced by anti-cancer drugs]. Gan To Kagaku Ryoho. 2002;29(4):563-7.
Ito, A., Hanawa, T., & Fujii, E. (2002). [The preventive effect of allopurinol spray on stomatitis induced by anti-cancer drugs]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 29(4), 563-7.
Ito A, Hanawa T, Fujii E. [The Preventive Effect of Allopurinol Spray On Stomatitis Induced By Anti-cancer Drugs]. Gan To Kagaku Ryoho. 2002;29(4):563-7. PubMed PMID: 11977540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The preventive effect of allopurinol spray on stomatitis induced by anti-cancer drugs]. AU - Ito,Akihiko, AU - Hanawa,Takehisa, AU - Fujii,Emiko, PY - 2002/4/30/pubmed PY - 2002/5/17/medline PY - 2002/4/30/entrez SP - 563 EP - 7 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 29 IS - 4 N2 - The present study was conducted to evaluate the effect of allopurinol spray on stomatitis induced by chemotherapy for esophageal cancer. The chemotherapeutics used consisted of 5-FU + CDDP (FC) given to 40 patients and 5-FU + ND (FN) given to 9 patients. Allopurinol solution for spray was prepared using a gelatin agent as base. The allopurinol spray was used 3-5 times daily before and after chemotherapy. The Japan Society for Cancer Therapy's criteria for stomatitis were used. With FN-therapy, no stomatitis was observed. With FC-therapy, 9 of 40 patients developed stomatitis of grade 1 (8 patients) or grade 2 (1). The incidence of stomatitis was 18.4% with all therapies and 22.5% with FC-therapy. The average graded toxicity was 0.20 for all therapies and 0.25 for FC-therapy. These results suggest that allopurinol spray is markedly effective for the prevention of stomatitis induced by chemotherapy. In addition, allopurinol spray is portable and convenient, and resulted in less nausea or vomiting than mouthwash. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/11977540/[The_preventive_effect_of_allopurinol_spray_on_stomatitis_induced_by_anti_cancer_drugs]_ L2 - https://medlineplus.gov/esophagealcancer.html DB - PRIME DP - Unbound Medicine ER -