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Osteochondroma after pediatric hematopoietic stem cell transplantation: report of eight cases.
Bone Marrow Transplant. 2002 Apr; 29(7):611-4.BM

Abstract

Eight children developed osteochondroma (OS) at a mean of 88 months after hematopoietic stem cell transplantation (HSCT). The mean age at HSCT was 56 months (12-84). This represents a cumulative incidence of 20% among patients less than 18 years of age transplanted from 1981 to 1997. These eight patients underwent allogeneic (n = 2) or autologous (n = 6) transplantation for either acute leukemia (n = 6) or neuroblastoma (n = 2) after a conditioning regimen including TBI (n = 7) or a combination of Bu and CY. OS was multiple in seven patients and solitary in one. Eight lesions were resected and all were benign. Four children received growth hormone before diagnosis of OS, but there was no clinical, radiological or histological difference between those who did not. Univariate analysis showed an increased rate associated only with autologous HSCT, with a 31.7% probability of a new OS at 12 years after HSCT. Osteochondroma should be added to the other adverse effects of HSCT in children.

Authors+Show Affiliations

Unité de Transplantation Médullaire, Hôpital d'Enfants, Nancy, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11979312

Citation

Bordigoni, P, et al. "Osteochondroma After Pediatric Hematopoietic Stem Cell Transplantation: Report of Eight Cases." Bone Marrow Transplantation, vol. 29, no. 7, 2002, pp. 611-4.
Bordigoni P, Turello R, Clement L, et al. Osteochondroma after pediatric hematopoietic stem cell transplantation: report of eight cases. Bone Marrow Transplant. 2002;29(7):611-4.
Bordigoni, P., Turello, R., Clement, L., Lascombes, P., Leheup, B., Galloy, M. A., & Plenat, F. (2002). Osteochondroma after pediatric hematopoietic stem cell transplantation: report of eight cases. Bone Marrow Transplantation, 29(7), 611-4.
Bordigoni P, et al. Osteochondroma After Pediatric Hematopoietic Stem Cell Transplantation: Report of Eight Cases. Bone Marrow Transplant. 2002;29(7):611-4. PubMed PMID: 11979312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteochondroma after pediatric hematopoietic stem cell transplantation: report of eight cases. AU - Bordigoni,P, AU - Turello,R, AU - Clement,L, AU - Lascombes,P, AU - Leheup,B, AU - Galloy,M A, AU - Plenat,F, PY - 2001/06/11/received PY - 2002/01/09/accepted PY - 2002/4/30/pubmed PY - 2002/9/26/medline PY - 2002/4/30/entrez SP - 611 EP - 4 JF - Bone marrow transplantation JO - Bone Marrow Transplant VL - 29 IS - 7 N2 - Eight children developed osteochondroma (OS) at a mean of 88 months after hematopoietic stem cell transplantation (HSCT). The mean age at HSCT was 56 months (12-84). This represents a cumulative incidence of 20% among patients less than 18 years of age transplanted from 1981 to 1997. These eight patients underwent allogeneic (n = 2) or autologous (n = 6) transplantation for either acute leukemia (n = 6) or neuroblastoma (n = 2) after a conditioning regimen including TBI (n = 7) or a combination of Bu and CY. OS was multiple in seven patients and solitary in one. Eight lesions were resected and all were benign. Four children received growth hormone before diagnosis of OS, but there was no clinical, radiological or histological difference between those who did not. Univariate analysis showed an increased rate associated only with autologous HSCT, with a 31.7% probability of a new OS at 12 years after HSCT. Osteochondroma should be added to the other adverse effects of HSCT in children. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/11979312/Osteochondroma_after_pediatric_hematopoietic_stem_cell_transplantation:_report_of_eight_cases_ L2 - https://doi.org/10.1038/sj.bmt.1703424 DB - PRIME DP - Unbound Medicine ER -