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No changes in serum fat-soluble vitamin and carotenoid concentrations with the intake of plant sterol/stanol esters in the context of a controlled diet.
Metabolism. 2002 May; 51(5):652-6.M

Abstract

Spreads enriched with plant sterol and stanol esters have been shown to possess similar cholesterol-lowering properties; however, their comparative capacity to alter circulating levels of other fat-soluble compounds has not been fully assessed. To compare actions of sterol and stanol ester consumption on serum fat-soluble vitamin and carotenoid concentrations, 15 hypercholesterolemic subjects were fed each of 3 fixed foods treatment diets over 21 days using a randomized crossover controlled design. Diets contained either (1) margarine (M), (2) margarine with sterol esters (MSE; 1.92 g/d), or (3) margarine with stanol esters (MSA; 1.76 g/d). No significant differences were found in initial or final serum fat-soluble vitamin and carotenoid concentrations among the 3 phases. Serum retinol and alpha- and gamma-tocopherol concentrations at baseline and endpoint and percentage changes relative to baseline for MSE and MSA were not significantly different from those of the M diet. After adjusting for total cholesterol reduction, no changes for alpha- and gamma-tocopherol were found. Serum vitamins D and K, lycopene, and lutein concentrations and percentage changes did not differ across diets. Serum concentrations at baseline and endpoint and percentage changes for alpha- and beta-cryptoxanthin and alpha- and gamma-carotene were not different among the diets, nor did serum alpha- and gamma-carotene concentrations to total cholesterol ratios differ. Serum lutein, beta-cryptoxanthin, and alpha-carotene concentrations increased over time. In conclusion, our results show no effect of consumption of esterified plant sterols or stanols on serum fat-soluble vitamin or carotenoid concentrations compared with a control diet.

Authors+Show Affiliations

School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences McGill University, 21,111 Lakeshore Road, Ste-Anne-de-Bellevue, Quebec, Canada H9X 3V9.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11979401

Citation

Raeini-Sarjaz, Mahmoud, et al. "No Changes in Serum Fat-soluble Vitamin and Carotenoid Concentrations With the Intake of Plant Sterol/stanol Esters in the Context of a Controlled Diet." Metabolism: Clinical and Experimental, vol. 51, no. 5, 2002, pp. 652-6.
Raeini-Sarjaz M, Ntanios FY, Vanstone CA, et al. No changes in serum fat-soluble vitamin and carotenoid concentrations with the intake of plant sterol/stanol esters in the context of a controlled diet. Metab Clin Exp. 2002;51(5):652-6.
Raeini-Sarjaz, M., Ntanios, F. Y., Vanstone, C. A., & Jones, P. J. (2002). No changes in serum fat-soluble vitamin and carotenoid concentrations with the intake of plant sterol/stanol esters in the context of a controlled diet. Metabolism: Clinical and Experimental, 51(5), 652-6.
Raeini-Sarjaz M, et al. No Changes in Serum Fat-soluble Vitamin and Carotenoid Concentrations With the Intake of Plant Sterol/stanol Esters in the Context of a Controlled Diet. Metab Clin Exp. 2002;51(5):652-6. PubMed PMID: 11979401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No changes in serum fat-soluble vitamin and carotenoid concentrations with the intake of plant sterol/stanol esters in the context of a controlled diet. AU - Raeini-Sarjaz,Mahmoud, AU - Ntanios,Fady Y, AU - Vanstone,Catherine A, AU - Jones,Peter J H, PY - 2002/4/30/pubmed PY - 2002/6/12/medline PY - 2002/4/30/entrez SP - 652 EP - 6 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 51 IS - 5 N2 - Spreads enriched with plant sterol and stanol esters have been shown to possess similar cholesterol-lowering properties; however, their comparative capacity to alter circulating levels of other fat-soluble compounds has not been fully assessed. To compare actions of sterol and stanol ester consumption on serum fat-soluble vitamin and carotenoid concentrations, 15 hypercholesterolemic subjects were fed each of 3 fixed foods treatment diets over 21 days using a randomized crossover controlled design. Diets contained either (1) margarine (M), (2) margarine with sterol esters (MSE; 1.92 g/d), or (3) margarine with stanol esters (MSA; 1.76 g/d). No significant differences were found in initial or final serum fat-soluble vitamin and carotenoid concentrations among the 3 phases. Serum retinol and alpha- and gamma-tocopherol concentrations at baseline and endpoint and percentage changes relative to baseline for MSE and MSA were not significantly different from those of the M diet. After adjusting for total cholesterol reduction, no changes for alpha- and gamma-tocopherol were found. Serum vitamins D and K, lycopene, and lutein concentrations and percentage changes did not differ across diets. Serum concentrations at baseline and endpoint and percentage changes for alpha- and beta-cryptoxanthin and alpha- and gamma-carotene were not different among the diets, nor did serum alpha- and gamma-carotene concentrations to total cholesterol ratios differ. Serum lutein, beta-cryptoxanthin, and alpha-carotene concentrations increased over time. In conclusion, our results show no effect of consumption of esterified plant sterols or stanols on serum fat-soluble vitamin or carotenoid concentrations compared with a control diet. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/11979401/No_changes_in_serum_fat_soluble_vitamin_and_carotenoid_concentrations_with_the_intake_of_plant_sterol/stanol_esters_in_the_context_of_a_controlled_diet_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026049502502316 DB - PRIME DP - Unbound Medicine ER -