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[Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency anemia].
Rinsho Ketsueki. 2002 Mar; 43(3):165-9.RK

Abstract

We investigated the efficacy of oral vitamin B12 (B12) therapy in patients with B12-deficiency anemia. Between June 1994 and June 2000, 17 patients, who were diagnosed as having B12-deficiency anemia and gave their informed consent, were enrolled in this study. Of these patients, 7 were further treated with a maintenance dose of methylcobalamin (1,500 micrograms daily for 7 days every 1-3 months). Correction of hematological and neurological abnormalities was prompt. The hemoglobin level and serum concentration of B12 were normalized within two months after starting the treatment. Recovery from neurological disturbance was observed within one month. To maintain a normal serum concentration of B12, a 7-day regime of administration was needed every month in 3 patients, every 2 months in 3 patients, and every 3 months in 1 patient. These results demonstrate the effectiveness of oral cobalamin therapy, and also that oral intermittent therapy is useful for maintaining a normal serum B12 concentration. Oral cobalamin therapy might be as effective as conventional injection therapy, and useful for long-term treatment.

Authors+Show Affiliations

Takasaki Y
Department of Hematology, Sasebo City General Hospital, Sasebo, Japan.
Moriuchi Y
No affiliation info available
Tsushima H
No affiliation info available
Ikeda E
No affiliation info available
Koura S
No affiliation info available
Taguchi J
No affiliation info available
Fukushima T
No affiliation info available
Tomonaga M
No affiliation info available
Ikeda S
No affiliation info available

MeSH

Administration, OralAdultAgedAged, 80 and overAnemia, PerniciousDrug Administration ScheduleFemaleHumansMaleMiddle AgedVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

11979747

Citation

Takasaki, Yumi, et al. "[Effectiveness of Oral Vitamin B12 Therapy for Pernicious Anemia and Vitamin B12 Deficiency Anemia]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 43, no. 3, 2002, pp. 165-9.
Takasaki Y, Moriuchi Y, Tsushima H, et al. [Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency anemia]. Rinsho Ketsueki. 2002;43(3):165-9.
Takasaki, Y., Moriuchi, Y., Tsushima, H., Ikeda, E., Koura, S., Taguchi, J., Fukushima, T., Tomonaga, M., & Ikeda, S. (2002). [Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency anemia]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 43(3), 165-9.
Takasaki Y, et al. [Effectiveness of Oral Vitamin B12 Therapy for Pernicious Anemia and Vitamin B12 Deficiency Anemia]. Rinsho Ketsueki. 2002;43(3):165-9. PubMed PMID: 11979747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency anemia]. AU - Takasaki,Yumi, AU - Moriuchi,Yukiyoshi, AU - Tsushima,Hideki, AU - Ikeda,Eiichirou, AU - Koura,Setsuko, AU - Taguchi,Jun, AU - Fukushima,Takuya, AU - Tomonaga,Masao, AU - Ikeda,Shuichi, PY - 2002/5/1/pubmed PY - 2002/5/9/medline PY - 2002/5/1/entrez SP - 165 EP - 9 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 43 IS - 3 N2 - We investigated the efficacy of oral vitamin B12 (B12) therapy in patients with B12-deficiency anemia. Between June 1994 and June 2000, 17 patients, who were diagnosed as having B12-deficiency anemia and gave their informed consent, were enrolled in this study. Of these patients, 7 were further treated with a maintenance dose of methylcobalamin (1,500 micrograms daily for 7 days every 1-3 months). Correction of hematological and neurological abnormalities was prompt. The hemoglobin level and serum concentration of B12 were normalized within two months after starting the treatment. Recovery from neurological disturbance was observed within one month. To maintain a normal serum concentration of B12, a 7-day regime of administration was needed every month in 3 patients, every 2 months in 3 patients, and every 3 months in 1 patient. These results demonstrate the effectiveness of oral cobalamin therapy, and also that oral intermittent therapy is useful for maintaining a normal serum B12 concentration. Oral cobalamin therapy might be as effective as conventional injection therapy, and useful for long-term treatment. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/11979747/[Effectiveness_of_oral_vitamin_B12_therapy_for_pernicious_anemia_and_vitamin_B12_deficiency_anemia]_ L2 - https://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -