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[Role of uropontin in calcium oxalate lithogenesis].
Prog Urol. 2002 Feb; 12(1):114-7.PU

Abstract

The formation of calcium oxalate stones involves four phases: nucleation, growth, aggregation and retention. Stone formation is a complex, multifactorial phenomenon involving, among other factors, proteins, some of which play an inhibitory role, while others play a promoting role. The authors studied the role of uropontin. Uropontin is the urinary form of osteopontin. Osteopontin is essentially involved in the mineralisation of bone tissue. Uropontin is secreted in the kidney by epithelial cells of the distal convoluted tubule and loop of Henle. Uropontin has an inhibitory action on the four phases of calcium oxalate crystal formation and is also one of the main constituents of the calcium oxalate stone matrix. A reduction of uropontin expression in epithelial cells induces a reduction of calcium oxalate stone formation. Uropontin is a protein largely involved in the lithogenesis of urinary stones, but its mechanism of action has not yet been fully elucidated.

Authors+Show Affiliations

Service de Chirurgie Urologique et Andrologie, CHRU Dupuytren, Limoges, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

11980003

Citation

Paulhac, Pascal, et al. "[Role of Uropontin in Calcium Oxalate Lithogenesis]." Progres En Urologie : Journal De l'Association Francaise D'urologie Et De La Societe Francaise D'urologie, vol. 12, no. 1, 2002, pp. 114-7.
Paulhac P, Desgrandchamps F, Dumas JP, et al. [Role of uropontin in calcium oxalate lithogenesis]. Prog Urol. 2002;12(1):114-7.
Paulhac, P., Desgrandchamps, F., Dumas, J. P., Teillac, P., Le Duc, A., & Colombeau, P. (2002). [Role of uropontin in calcium oxalate lithogenesis]. Progres En Urologie : Journal De l'Association Francaise D'urologie Et De La Societe Francaise D'urologie, 12(1), 114-7.
Paulhac P, et al. [Role of Uropontin in Calcium Oxalate Lithogenesis]. Prog Urol. 2002;12(1):114-7. PubMed PMID: 11980003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Role of uropontin in calcium oxalate lithogenesis]. AU - Paulhac,Pascal, AU - Desgrandchamps,François, AU - Dumas,Jean-Philippe, AU - Teillac,Pierre, AU - Le Duc,Alain, AU - Colombeau,Pierre, PY - 2002/5/1/pubmed PY - 2002/12/10/medline PY - 2002/5/1/entrez SP - 114 EP - 7 JF - Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie JO - Prog Urol VL - 12 IS - 1 N2 - The formation of calcium oxalate stones involves four phases: nucleation, growth, aggregation and retention. Stone formation is a complex, multifactorial phenomenon involving, among other factors, proteins, some of which play an inhibitory role, while others play a promoting role. The authors studied the role of uropontin. Uropontin is the urinary form of osteopontin. Osteopontin is essentially involved in the mineralisation of bone tissue. Uropontin is secreted in the kidney by epithelial cells of the distal convoluted tubule and loop of Henle. Uropontin has an inhibitory action on the four phases of calcium oxalate crystal formation and is also one of the main constituents of the calcium oxalate stone matrix. A reduction of uropontin expression in epithelial cells induces a reduction of calcium oxalate stone formation. Uropontin is a protein largely involved in the lithogenesis of urinary stones, but its mechanism of action has not yet been fully elucidated. SN - 1166-7087 UR - https://www.unboundmedicine.com/medline/citation/11980003/[Role_of_uropontin_in_calcium_oxalate_lithogenesis]_ L2 - https://antibodies.cancer.gov/detail/CPTC-SPP1-1 DB - PRIME DP - Unbound Medicine ER -