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Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets.
In Vivo. 2002 Jan-Feb; 16(1):25-8.V

Abstract

BACKGROUND

Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies.

MATERIALS AND METHODS

CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation.

RESULTS

CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work.

CONCLUSIONS

Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory.

Authors+Show Affiliations

Department of Community Dentistry, Dental School, University of Texas Health Science Center, San Antonio, TX 78284, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11980356

Citation

Johnson-Alvares, Dorthea, et al. "Salivary CA130 With and Without Unilateral Autonomic Parotid Denervation of Rats Fed Different Diets." In Vivo (Athens, Greece), vol. 16, no. 1, 2002, pp. 25-8.
Johnson-Alvares D, Cornélissen G, Portela A, et al. Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets. In Vivo. 2002;16(1):25-8.
Johnson-Alvares, D., Cornélissen, G., Portela, A., Halberg, E., Rudney, J. D., Yeh, C. K., Dodds, M., Haus, E., Schaffer, E., Blank, M., & Halberg, F. (2002). Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets. In Vivo (Athens, Greece), 16(1), 25-8.
Johnson-Alvares D, et al. Salivary CA130 With and Without Unilateral Autonomic Parotid Denervation of Rats Fed Different Diets. In Vivo. 2002 Jan-Feb;16(1):25-8. PubMed PMID: 11980356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salivary CA130 with and without unilateral autonomic parotid denervation of rats fed different diets. AU - Johnson-Alvares,Dorthea, AU - Cornélissen,Germaine, AU - Portela,Ana, AU - Halberg,Erna, AU - Rudney,Joel D, AU - Yeh,Chih-Ko, AU - Dodds,Michael, AU - Haus,Erhard, AU - Schaffer,Erwin, AU - Blank,Mikhail, AU - Halberg,Franz, PY - 2002/5/1/pubmed PY - 2002/10/31/medline PY - 2002/5/1/entrez SP - 25 EP - 8 JF - In vivo (Athens, Greece) JO - In Vivo VL - 16 IS - 1 N2 - BACKGROUND: Tumor markers such as CA130 can be determined in human whole saliva. Saliva represents an attractive body fluid for longitudinal studies. MATERIALS AND METHODS: CA130 was determined in parotid saliva from 8 rats fed different diets, with or without autonomic denervation. RESULTS: CA130 could be determined in parotid saliva of rats, irrespective of diet and/or autonomic denervation. Whether the numerical decrease in CA130 observed after autonomic denervation is statistically significant requires further work. CONCLUSIONS: Since salivary CA130 has been shown to decrease following treatment with anti-cancer drugs in humans, the ability to determine this tumor marker in rat saliva opens new opportunities for optimizing cancer chronotherapy in the experimental laboratory. SN - 0258-851X UR - https://www.unboundmedicine.com/medline/citation/11980356/Salivary_CA130_with_and_without_unilateral_autonomic_parotid_denervation_of_rats_fed_different_diets_ DB - PRIME DP - Unbound Medicine ER -