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Synaptic association of dopaminergic axon terminals and neurokinin-1 receptor-expressing intrinsic neurons in the striatum of the rat.
Neurosci Lett. 2002 May 10; 324(1):9-12.NL

Abstract

We examined if axon terminals of dopaminergic neurons might make synapses upon neurokinin-1 receptor (NK1R)-expressing intrinsic neurons in the rat striatum. In a double-immunocytochemical ultrastructural study, dopaminergic terminals were labeled by the immunoperoxidase method for tyrosine hydroxylase (TH), while NK1R-immunoreactivity (-IR) was revealed by the immunogold-silver labeling method. Some TH-immunoreactive (-ir) axon terminals formed synapses of the symmetric or intermediate type on NK1R-ir neuronal profiles; usually on dendritic profiles and rarely on somatic profiles. It was further confirmed by means of triple-immunofluorescence histochemistry that NK1R-ir neurons in close association with TH-ir axon terminals showed nitric oxide synthase (NOS)- or vesicular acetylcholine transporter-IR. Since NK1R-expressing striatal neurons are segregated into cholinergic and somatostatin/NOS-containing intrinsic neurons (Brain Res. 631 (1993) 297; Neurosci. Lett. 310 (2001) 109), the present results indicate that dopaminergic neurons make synapses upon these intrinsic neurons in the striatum.

Authors+Show Affiliations

Department of Anatomy and K.K. Leung Brain Research Center, The Fourth Military Medical University, Xi'an 710032, People's Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11983282

Citation

Li, Jin-Lian, et al. "Synaptic Association of Dopaminergic Axon Terminals and Neurokinin-1 Receptor-expressing Intrinsic Neurons in the Striatum of the Rat." Neuroscience Letters, vol. 324, no. 1, 2002, pp. 9-12.
Li JL, Kaneko T, Mizuno N. Synaptic association of dopaminergic axon terminals and neurokinin-1 receptor-expressing intrinsic neurons in the striatum of the rat. Neurosci Lett. 2002;324(1):9-12.
Li, J. L., Kaneko, T., & Mizuno, N. (2002). Synaptic association of dopaminergic axon terminals and neurokinin-1 receptor-expressing intrinsic neurons in the striatum of the rat. Neuroscience Letters, 324(1), 9-12.
Li JL, Kaneko T, Mizuno N. Synaptic Association of Dopaminergic Axon Terminals and Neurokinin-1 Receptor-expressing Intrinsic Neurons in the Striatum of the Rat. Neurosci Lett. 2002 May 10;324(1):9-12. PubMed PMID: 11983282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synaptic association of dopaminergic axon terminals and neurokinin-1 receptor-expressing intrinsic neurons in the striatum of the rat. AU - Li,Jin-Lian, AU - Kaneko,Takeshi, AU - Mizuno,Noboru, PY - 2002/5/2/pubmed PY - 2002/7/13/medline PY - 2002/5/2/entrez SP - 9 EP - 12 JF - Neuroscience letters JO - Neurosci. Lett. VL - 324 IS - 1 N2 - We examined if axon terminals of dopaminergic neurons might make synapses upon neurokinin-1 receptor (NK1R)-expressing intrinsic neurons in the rat striatum. In a double-immunocytochemical ultrastructural study, dopaminergic terminals were labeled by the immunoperoxidase method for tyrosine hydroxylase (TH), while NK1R-immunoreactivity (-IR) was revealed by the immunogold-silver labeling method. Some TH-immunoreactive (-ir) axon terminals formed synapses of the symmetric or intermediate type on NK1R-ir neuronal profiles; usually on dendritic profiles and rarely on somatic profiles. It was further confirmed by means of triple-immunofluorescence histochemistry that NK1R-ir neurons in close association with TH-ir axon terminals showed nitric oxide synthase (NOS)- or vesicular acetylcholine transporter-IR. Since NK1R-expressing striatal neurons are segregated into cholinergic and somatostatin/NOS-containing intrinsic neurons (Brain Res. 631 (1993) 297; Neurosci. Lett. 310 (2001) 109), the present results indicate that dopaminergic neurons make synapses upon these intrinsic neurons in the striatum. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/11983282/Synaptic_association_of_dopaminergic_axon_terminals_and_neurokinin_1_receptor_expressing_intrinsic_neurons_in_the_striatum_of_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394002001386 DB - PRIME DP - Unbound Medicine ER -