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The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease.
J Nutr. 2002 May; 132(5):1062S-1101S.JN

Abstract

The author and four independent experts evaluated the intent and quality of scientific evidence for a potential beneficial health relationship between the intake of walnuts and the reduction and prevention of coronary heart disease. The report also addresses the supporting evidence for the health benefit of other tree nuts and selected legumes. Compared to most other nuts, which contain monounsaturated fatty acids, walnuts are unique because they are rich in n-6 (linoleate) and n-3 (linolenate) polyunsaturated fatty acids. Walnuts contain multiple health-beneficial components, such as having a low lysine:arginine ratio and high levels of arginine, folate, fiber, tannins, and polyphenols. Though walnuts are energy rich, clinical dietary intervention studies show that walnut consumption does not cause a net gain in body weight when eaten as a replacement food. Five controlled, peer-reviewed, human clinical walnut intervention trials, involving approximately 200 subjects representative of the 51% of the adult population in the United States at risk of coronary heart disease were reviewed. The intervention trials consistently demonstrated walnuts as part of a heart-healthy diet, lower blood cholesterol concentrations. None of these studies were of extended duration that would be essential for evaluation of the sustainability of the observed outcomes. These results were supported by several large prospective observational studies in humans, all demonstrating a dose response-related inverse association of the relative risk of coronary heart disease with the frequent daily consumption of small amounts of nuts, including walnuts.

Authors+Show Affiliations

Medical College of Georgia, Augusta, GA, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11983840

Citation

Feldman, Elaine B.. "The Scientific Evidence for a Beneficial Health Relationship Between Walnuts and Coronary Heart Disease." The Journal of Nutrition, vol. 132, no. 5, 2002, 1062S-1101S.
Feldman EB. The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. J Nutr. 2002;132(5):1062S-1101S.
Feldman, E. B. (2002). The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. The Journal of Nutrition, 132(5), 1062S-1101S.
Feldman EB. The Scientific Evidence for a Beneficial Health Relationship Between Walnuts and Coronary Heart Disease. J Nutr. 2002;132(5):1062S-1101S. PubMed PMID: 11983840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. A1 - Feldman,Elaine B, PY - 2002/5/2/pubmed PY - 2002/5/31/medline PY - 2002/5/2/entrez SP - 1062S EP - 1101S JF - The Journal of nutrition JO - J. Nutr. VL - 132 IS - 5 N2 - The author and four independent experts evaluated the intent and quality of scientific evidence for a potential beneficial health relationship between the intake of walnuts and the reduction and prevention of coronary heart disease. The report also addresses the supporting evidence for the health benefit of other tree nuts and selected legumes. Compared to most other nuts, which contain monounsaturated fatty acids, walnuts are unique because they are rich in n-6 (linoleate) and n-3 (linolenate) polyunsaturated fatty acids. Walnuts contain multiple health-beneficial components, such as having a low lysine:arginine ratio and high levels of arginine, folate, fiber, tannins, and polyphenols. Though walnuts are energy rich, clinical dietary intervention studies show that walnut consumption does not cause a net gain in body weight when eaten as a replacement food. Five controlled, peer-reviewed, human clinical walnut intervention trials, involving approximately 200 subjects representative of the 51% of the adult population in the United States at risk of coronary heart disease were reviewed. The intervention trials consistently demonstrated walnuts as part of a heart-healthy diet, lower blood cholesterol concentrations. None of these studies were of extended duration that would be essential for evaluation of the sustainability of the observed outcomes. These results were supported by several large prospective observational studies in humans, all demonstrating a dose response-related inverse association of the relative risk of coronary heart disease with the frequent daily consumption of small amounts of nuts, including walnuts. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/11983840/The_scientific_evidence_for_a_beneficial_health_relationship_between_walnuts_and_coronary_heart_disease_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/132.5.1062S DB - PRIME DP - Unbound Medicine ER -