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Cytomegalovirus as a cause of anterior uveitis with sectoral iris atrophy.
Ophthalmology. 2002 May; 109(5):879-82.O

Abstract

OBJECTIVE

To report two cases of recurrent anterior uveitis with sectoral iris atrophy and ocular hypertension during attacks caused by cytomegalovirus (CMV).

DESIGN

Two observational case reports.

PARTICIPANTS

Two immunocompetent patients with a history of recurrent unilateral hypertensive anterior uveitis with sectoral iris atrophy were referred to us with the presumptive diagnosis of herpetic uveitis.

MAIN OUTCOME MEASURES

Comprehensive ophthalmic examination, aqueous humor polymerase chain reaction (PCR), and peripheral blood serologic studies were performed on both patients.

RESULTS

Examination of aqueous humor by PCR was positive for CMV and negative for herpesvirus. Serum IgG/IgM titers disclosed past CMV infection. Both patients responded well to antiviral therapy with ganciclovir. The final visual acuity level was 20/20 in both eyes of both patients.

CONCLUSIONS

CMV infection can produce recurrent attacks of anterior uveitis with clinical characteristics indistinguishable from those previously considered highly suggestive or even pathognomonic for herpetic infection. This observation has implications for the therapeutic management of such patients.

Authors+Show Affiliations

Ocular Inflammation and Immunology Service, Department of Ophthalmology, General Hospital of Athens, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

11986091

Citation

Markomichelakis, Nikos N., et al. "Cytomegalovirus as a Cause of Anterior Uveitis With Sectoral Iris Atrophy." Ophthalmology, vol. 109, no. 5, 2002, pp. 879-82.
Markomichelakis NN, Canakis C, Zafirakis P, et al. Cytomegalovirus as a cause of anterior uveitis with sectoral iris atrophy. Ophthalmology. 2002;109(5):879-82.
Markomichelakis, N. N., Canakis, C., Zafirakis, P., Marakis, T., Mallias, I., & Theodossiadis, G. (2002). Cytomegalovirus as a cause of anterior uveitis with sectoral iris atrophy. Ophthalmology, 109(5), 879-82.
Markomichelakis NN, et al. Cytomegalovirus as a Cause of Anterior Uveitis With Sectoral Iris Atrophy. Ophthalmology. 2002;109(5):879-82. PubMed PMID: 11986091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytomegalovirus as a cause of anterior uveitis with sectoral iris atrophy. AU - Markomichelakis,Nikos N, AU - Canakis,Christina, AU - Zafirakis,Panayotis, AU - Marakis,Theodoros, AU - Mallias,Ioannis, AU - Theodossiadis,George, PY - 2002/5/3/pubmed PY - 2002/5/17/medline PY - 2002/5/3/entrez SP - 879 EP - 82 JF - Ophthalmology JO - Ophthalmology VL - 109 IS - 5 N2 - OBJECTIVE: To report two cases of recurrent anterior uveitis with sectoral iris atrophy and ocular hypertension during attacks caused by cytomegalovirus (CMV). DESIGN: Two observational case reports. PARTICIPANTS: Two immunocompetent patients with a history of recurrent unilateral hypertensive anterior uveitis with sectoral iris atrophy were referred to us with the presumptive diagnosis of herpetic uveitis. MAIN OUTCOME MEASURES: Comprehensive ophthalmic examination, aqueous humor polymerase chain reaction (PCR), and peripheral blood serologic studies were performed on both patients. RESULTS: Examination of aqueous humor by PCR was positive for CMV and negative for herpesvirus. Serum IgG/IgM titers disclosed past CMV infection. Both patients responded well to antiviral therapy with ganciclovir. The final visual acuity level was 20/20 in both eyes of both patients. CONCLUSIONS: CMV infection can produce recurrent attacks of anterior uveitis with clinical characteristics indistinguishable from those previously considered highly suggestive or even pathognomonic for herpetic infection. This observation has implications for the therapeutic management of such patients. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/11986091/Cytomegalovirus_as_a_cause_of_anterior_uveitis_with_sectoral_iris_atrophy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(02)00961-2 DB - PRIME DP - Unbound Medicine ER -