Tags

Type your tag names separated by a space and hit enter

Dietary modulation of circulating leptin levels: site-specific changes in fat deposition and ob mRNA expression.
Horm Metab Res. 2002 Apr; 34(4):176-81.HM

Abstract

In order to study the effects of diet on fat distribution, circulating leptin levels and ob mRNA expression, diets of different macronutrient composition were fed to lean mice and gold thioglucose-obese mice. A high-fat diet and 2 high-carbohydrate diets, one containing mostly high-glycaemic-index starch and the other containing low-glycaemic-index starch were fed ad libitum for 10 weeks and were compared to standard laboratory chow. Weight gain was attenuated by feeding low-glycaemic-index starch in all mice and by feeding a high-fat diet in lean mice. Reduced adiposity was seen in lean mice fed low-glycaemic-index starch, whereas increased adiposity was seen in both lean and obese mice fed on the high-fat diet. Circulating leptin levels, when corrected for adiposity, were decreased in all mice fed either the high-fat diet or the low-GI diet. In epididymal fat pads, decreased ob mRNA expression was seen after both high-fat and high-glycaemic-index starch feeding. These results show that diet macronutrient composition contributes to the variability of circulating leptin levels by the combined effects of diet on fat distribution and on site-specific changes in ob mRNA expression.

Authors+Show Affiliations

Human Nutrition Unit, Department of Biochemistry, University of Sydney, Sydney NSW 2006, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11987025

Citation

Walker, C G., et al. "Dietary Modulation of Circulating Leptin Levels: Site-specific Changes in Fat Deposition and Ob mRNA Expression." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 34, no. 4, 2002, pp. 176-81.
Walker CG, Bryson JM, Phuyal JL, et al. Dietary modulation of circulating leptin levels: site-specific changes in fat deposition and ob mRNA expression. Horm Metab Res. 2002;34(4):176-81.
Walker, C. G., Bryson, J. M., Phuyal, J. L., & Caterson, I. D. (2002). Dietary modulation of circulating leptin levels: site-specific changes in fat deposition and ob mRNA expression. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 34(4), 176-81.
Walker CG, et al. Dietary Modulation of Circulating Leptin Levels: Site-specific Changes in Fat Deposition and Ob mRNA Expression. Horm Metab Res. 2002;34(4):176-81. PubMed PMID: 11987025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary modulation of circulating leptin levels: site-specific changes in fat deposition and ob mRNA expression. AU - Walker,C G, AU - Bryson,J M, AU - Phuyal,J L, AU - Caterson,I D, PY - 2002/5/3/pubmed PY - 2003/6/6/medline PY - 2002/5/3/entrez SP - 176 EP - 81 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 34 IS - 4 N2 - In order to study the effects of diet on fat distribution, circulating leptin levels and ob mRNA expression, diets of different macronutrient composition were fed to lean mice and gold thioglucose-obese mice. A high-fat diet and 2 high-carbohydrate diets, one containing mostly high-glycaemic-index starch and the other containing low-glycaemic-index starch were fed ad libitum for 10 weeks and were compared to standard laboratory chow. Weight gain was attenuated by feeding low-glycaemic-index starch in all mice and by feeding a high-fat diet in lean mice. Reduced adiposity was seen in lean mice fed low-glycaemic-index starch, whereas increased adiposity was seen in both lean and obese mice fed on the high-fat diet. Circulating leptin levels, when corrected for adiposity, were decreased in all mice fed either the high-fat diet or the low-GI diet. In epididymal fat pads, decreased ob mRNA expression was seen after both high-fat and high-glycaemic-index starch feeding. These results show that diet macronutrient composition contributes to the variability of circulating leptin levels by the combined effects of diet on fat distribution and on site-specific changes in ob mRNA expression. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/11987025/Dietary_modulation_of_circulating_leptin_levels:_site_specific_changes_in_fat_deposition_and_ob_mRNA_expression_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2002-26707 DB - PRIME DP - Unbound Medicine ER -