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Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells.
Science. 2002 May 03; 296(5569):927-31.Sci

Abstract

Demyelination results in severe disability in many neurodegenerative diseases and nervous system infections, and it is typically mediated by inflammatory responses. Mycobacterium leprae, the causative organism of leprosy, induced rapid demyelination by a contact-dependent mechanism in the absence of immune cells in an in vitro nerve tissue culture model and in Rag1-knockout (Rag1-/-) mice, which lack mature B and T lymphocytes. Myelinated Schwann cells were resistant to M. leprae invasion but undergo demyelination upon bacterial attachment, whereas nonmyelinated Schwann cells harbor intracellular M. leprae in large numbers. During M. leprae-induced demyelination, Schwann cells proliferate significantly both in vitro and in vivo and generate a more nonmyelinated phenotype, thereby securing the intracellular niche for M. leprae.

Authors+Show Affiliations

Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY 10021, USA. rambuka@mail.rockefeller.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11988579

Citation

Rambukkana, Anura, et al. "Contact-dependent Demyelination By Mycobacterium Leprae in the Absence of Immune Cells." Science (New York, N.Y.), vol. 296, no. 5569, 2002, pp. 927-31.
Rambukkana A, Zanazzi G, Tapinos N, et al. Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells. Science. 2002;296(5569):927-31.
Rambukkana, A., Zanazzi, G., Tapinos, N., & Salzer, J. L. (2002). Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells. Science (New York, N.Y.), 296(5569), 927-31.
Rambukkana A, et al. Contact-dependent Demyelination By Mycobacterium Leprae in the Absence of Immune Cells. Science. 2002 May 3;296(5569):927-31. PubMed PMID: 11988579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells. AU - Rambukkana,Anura, AU - Zanazzi,George, AU - Tapinos,Nikos, AU - Salzer,James L, PY - 2002/5/4/pubmed PY - 2002/5/31/medline PY - 2002/5/4/entrez SP - 927 EP - 31 JF - Science (New York, N.Y.) JO - Science VL - 296 IS - 5569 N2 - Demyelination results in severe disability in many neurodegenerative diseases and nervous system infections, and it is typically mediated by inflammatory responses. Mycobacterium leprae, the causative organism of leprosy, induced rapid demyelination by a contact-dependent mechanism in the absence of immune cells in an in vitro nerve tissue culture model and in Rag1-knockout (Rag1-/-) mice, which lack mature B and T lymphocytes. Myelinated Schwann cells were resistant to M. leprae invasion but undergo demyelination upon bacterial attachment, whereas nonmyelinated Schwann cells harbor intracellular M. leprae in large numbers. During M. leprae-induced demyelination, Schwann cells proliferate significantly both in vitro and in vivo and generate a more nonmyelinated phenotype, thereby securing the intracellular niche for M. leprae. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/11988579/Contact_dependent_demyelination_by_Mycobacterium_leprae_in_the_absence_of_immune_cells_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=11988579 DB - PRIME DP - Unbound Medicine ER -