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Dietary intake of folate and risk of stroke in US men and women: NHANES I Epidemiologic Follow-up Study. National Health and Nutrition Examination Survey.

Abstract

BACKGROUND AND PURPOSE

Few population-based studies have examined the relationship between dietary intake of folate and risk of stroke and cardiovascular disease (CVD). This study examines the association between dietary intake of folate and the subsequent risk of stroke and CVD.

METHODS

Study participants included 9764 US men and women aged 25 to 74 years who participated in the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study (NHEFS) and were free of CVD at baseline. Dietary intake of folate was assessed at baseline using a 24-hour dietary recall and calculated using ESHA software. Incidence data for stroke and CVD were obtained from medical records and death certificates.

RESULTS

Over an average of 19 years of follow-up, 926 incident stroke events and 3758 incident CVD events were documented. The relative risk (RR) was 0.79 (95% confidence interval [CI], 0.63 to 0.99, P=0.03 for trend) for incident stroke events and 0.86 (95% CI: 0.78 to 0.95, P<0.001 for trend) for incident CVD events in the highest quartile of dietary folate intake (median, 405.0 microg/day) compared with those in the lowest quartile (median, 99.0 microg/day), after adjustment for established cardiovascular risk factors and dietary factors.

CONCLUSIONS

Our findings indicate an inverse relationship between dietary intake of folate and subsequent risk of stroke and CVD. Increasing dietary intake of folate from food sources may be an important approach to the prevention of CVD in the US population.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, La 70112, USA.

    , , , , ,

    Source

    Stroke 33:5 2002 May pg 1183-8

    MeSH

    Adult
    Aged
    Cardiovascular Diseases
    Cohort Studies
    Continental Population Groups
    Databases, Factual
    Diet
    Dietary Fats
    Energy Intake
    Female
    Folic Acid
    Follow-Up Studies
    Humans
    Incidence
    Male
    Middle Aged
    Nutrition Surveys
    Proportional Hazards Models
    Prospective Studies
    Risk
    Risk Assessment
    Risk Factors
    Stroke
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11988588

    Citation

    Bazzano, Lydia A., et al. "Dietary Intake of Folate and Risk of Stroke in US Men and Women: NHANES I Epidemiologic Follow-up Study. National Health and Nutrition Examination Survey." Stroke, vol. 33, no. 5, 2002, pp. 1183-8.
    Bazzano LA, He J, Ogden LG, et al. Dietary intake of folate and risk of stroke in US men and women: NHANES I Epidemiologic Follow-up Study. National Health and Nutrition Examination Survey. Stroke. 2002;33(5):1183-8.
    Bazzano, L. A., He, J., Ogden, L. G., Loria, C., Vupputuri, S., Myers, L., & Whelton, P. K. (2002). Dietary intake of folate and risk of stroke in US men and women: NHANES I Epidemiologic Follow-up Study. National Health and Nutrition Examination Survey. Stroke, 33(5), pp. 1183-8.
    Bazzano LA, et al. Dietary Intake of Folate and Risk of Stroke in US Men and Women: NHANES I Epidemiologic Follow-up Study. National Health and Nutrition Examination Survey. Stroke. 2002;33(5):1183-8. PubMed PMID: 11988588.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake of folate and risk of stroke in US men and women: NHANES I Epidemiologic Follow-up Study. National Health and Nutrition Examination Survey. AU - Bazzano,Lydia A, AU - He,Jiang, AU - Ogden,Lorraine G, AU - Loria,Catherine, AU - Vupputuri,Suma, AU - Myers,Leann, AU - Whelton,Paul K, PY - 2002/5/4/pubmed PY - 2002/5/15/medline PY - 2002/5/4/entrez SP - 1183 EP - 8 JF - Stroke JO - Stroke VL - 33 IS - 5 N2 - BACKGROUND AND PURPOSE: Few population-based studies have examined the relationship between dietary intake of folate and risk of stroke and cardiovascular disease (CVD). This study examines the association between dietary intake of folate and the subsequent risk of stroke and CVD. METHODS: Study participants included 9764 US men and women aged 25 to 74 years who participated in the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study (NHEFS) and were free of CVD at baseline. Dietary intake of folate was assessed at baseline using a 24-hour dietary recall and calculated using ESHA software. Incidence data for stroke and CVD were obtained from medical records and death certificates. RESULTS: Over an average of 19 years of follow-up, 926 incident stroke events and 3758 incident CVD events were documented. The relative risk (RR) was 0.79 (95% confidence interval [CI], 0.63 to 0.99, P=0.03 for trend) for incident stroke events and 0.86 (95% CI: 0.78 to 0.95, P<0.001 for trend) for incident CVD events in the highest quartile of dietary folate intake (median, 405.0 microg/day) compared with those in the lowest quartile (median, 99.0 microg/day), after adjustment for established cardiovascular risk factors and dietary factors. CONCLUSIONS: Our findings indicate an inverse relationship between dietary intake of folate and subsequent risk of stroke and CVD. Increasing dietary intake of folate from food sources may be an important approach to the prevention of CVD in the US population. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/11988588/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=11988588 DB - PRIME DP - Unbound Medicine ER -