Tags

Type your tag names separated by a space and hit enter

[Acute generalized exanthematous pustulosis due to fluconazole].
Ann Dermatol Venereol. 2002 Mar; 129(3):294-7.AD

Abstract

INTRODUCTION

Fluconazole (Triflucan(R)), a systemic triazole antifungal agent is largely prescribed and some cutaneous side effects have already been described. We report the first case of acute generalized exanthematous pustulosis due to this molecule in a patient with cutaneous candidosis.

CASE REPORT

A 65 year-old-woman was treated with fluconazole (200 mg/day) for a persistent cutaneous candidosis infection on the buttocks. After the third dose, the patient presented with a pustular eruption with erythema located on her trunk and in her large skin folds. The eruption was associated with fever at 39 degrees C, asthenia and neutrophilia (9,000/mm(3)). The histologic examination and the negativity of microbiological cultures were consistent with the diagnosis of acute generalized exanthematous pustulosis. The eruption cleared with local steroids in about ten days. Nineteen days later, the same pustular eruption occurred but without fever nor neutrophilia.

DISCUSSION

Clinical, biological and histological manifestations were consistent with the diagnosis of acute generalized exanthematous pustulosis due to fluconazole. According to the imputability criteria of Begaud et al., intrinsic imputability of fluconazole was possible (I2). According to the classification of the EuroSCAR study, it was certain. No similar case of recurrence had already been described after the withdrawal of the molecule. We believe this is the first case of acute generalized exanthematous pustulosis due to fluconazole (extrinsic imputability: B0).

Links

Publisher Full Text
em-consulte.com
em-consulte.com

Authors+Show Affiliations

Fabre B
Service de Dermatologie, CHU Purpan, Place du Dr Baylac, 31059 Toulouse Cedex.
Albès B
No affiliation info available
Belhadjali H
No affiliation info available
Bazex J
No affiliation info available

MeSH

Acute DiseaseAgedDrug EruptionsExanthemaFemaleFluconazoleHumansSkin Diseases, Vesiculobullous

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

11988684

Citation

Fabre, B, et al. "[Acute Generalized Exanthematous Pustulosis Due to Fluconazole]." Annales De Dermatologie Et De Venereologie, vol. 129, no. 3, 2002, pp. 294-7.
Fabre B, Albès B, Belhadjali H, et al. [Acute generalized exanthematous pustulosis due to fluconazole]. Ann Dermatol Venereol. 2002;129(3):294-7.
Fabre, B., Albès, B., Belhadjali, H., & Bazex, J. (2002). [Acute generalized exanthematous pustulosis due to fluconazole]. Annales De Dermatologie Et De Venereologie, 129(3), 294-7.
Fabre B, et al. [Acute Generalized Exanthematous Pustulosis Due to Fluconazole]. Ann Dermatol Venereol. 2002;129(3):294-7. PubMed PMID: 11988684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acute generalized exanthematous pustulosis due to fluconazole]. AU - Fabre,B, AU - Albès,B, AU - Belhadjali,H, AU - Bazex,J, PY - 2002/5/4/pubmed PY - 2002/12/17/medline PY - 2002/5/4/entrez SP - 294 EP - 7 JF - Annales de dermatologie et de venereologie JO - Ann Dermatol Venereol VL - 129 IS - 3 N2 - INTRODUCTION: Fluconazole (Triflucan(R)), a systemic triazole antifungal agent is largely prescribed and some cutaneous side effects have already been described. We report the first case of acute generalized exanthematous pustulosis due to this molecule in a patient with cutaneous candidosis. CASE REPORT: A 65 year-old-woman was treated with fluconazole (200 mg/day) for a persistent cutaneous candidosis infection on the buttocks. After the third dose, the patient presented with a pustular eruption with erythema located on her trunk and in her large skin folds. The eruption was associated with fever at 39 degrees C, asthenia and neutrophilia (9,000/mm(3)). The histologic examination and the negativity of microbiological cultures were consistent with the diagnosis of acute generalized exanthematous pustulosis. The eruption cleared with local steroids in about ten days. Nineteen days later, the same pustular eruption occurred but without fever nor neutrophilia. DISCUSSION: Clinical, biological and histological manifestations were consistent with the diagnosis of acute generalized exanthematous pustulosis due to fluconazole. According to the imputability criteria of Begaud et al., intrinsic imputability of fluconazole was possible (I2). According to the classification of the EuroSCAR study, it was certain. No similar case of recurrence had already been described after the withdrawal of the molecule. We believe this is the first case of acute generalized exanthematous pustulosis due to fluconazole (extrinsic imputability: B0). SN - 0151-9638 UR - https://www.unboundmedicine.com/medline/citation/11988684/[Acute_generalized_exanthematous_pustulosis_due_to_fluconazole]_ L2 - http://www.em-consulte.com/retrieve/pii/MDOI-ad-03-2002-129-3-0151-9638-101019-art5 DB - PRIME DP - Unbound Medicine ER -