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[Bullous amyloidosis].
Ann Dermatol Venereol. 2002 Mar; 129(3):299-302.AD

Abstract

INTRODUCTION

The occurrence of skin damage during systemic amyloidosis is common, but the appearance of bullous lesions is rare. Only twenty-seven cases have been reported in the literature. We report our observation of bullous amyloidosis during progression of renal amyloidosis.

OBSERVATION

A 61 year-old man, presented with white, soft, palpebral edemas of the lower limbs, without scutulum involvement, associated with a large cubital nerve that had appeared in March 1997. Biological explorations revealed a nephrotic syndrome. Pathologic study of the renal biopsy concluded in amyloidosis. Treatment with colchinine stabilized the renal damage. One year later, a non-pruriginous, papular and bullous eruption occurred, localized essentially in the axillary and inguinal-crural folds of the forearms and legs. In the presence of an amyloidal deposit and intra-epidermal detachment, the cutaneous biopsy was evocative of bullous amyloidosis. The search for concomitant myeloma was negative. Treatment with colchinine was effective. The bullous lesions disappeared after 2 months, and 21 months later, renal damage was still stable.

DISCUSSION

These particularities in evolution are exceptional and have never been described. A hypothetical modification in the physico-chemical properties of the amyloidal protein might explain the bullous eruption and stabilization of renal damage.

Authors+Show Affiliations

Service de Médecine Interne, Hôpital la Rabta, Tunis, Tunisie. houman.habib@rns.tnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

11988685

Citation

Houman, M H., et al. "[Bullous Amyloidosis]." Annales De Dermatologie Et De Venereologie, vol. 129, no. 3, 2002, pp. 299-302.
Houman MH, Smiti Khanfir M, Ben Ghorbel I, et al. [Bullous amyloidosis]. Ann Dermatol Venereol. 2002;129(3):299-302.
Houman, M. H., Smiti Khanfir, M., Ben Ghorbel, I., Mokni, M., Jerbi, E., Boubaker, S., Ben Osman Dhari, A., & Miled, M. (2002). [Bullous amyloidosis]. Annales De Dermatologie Et De Venereologie, 129(3), 299-302.
Houman MH, et al. [Bullous Amyloidosis]. Ann Dermatol Venereol. 2002;129(3):299-302. PubMed PMID: 11988685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bullous amyloidosis]. AU - Houman,M H, AU - Smiti Khanfir,M, AU - Ben Ghorbel,I, AU - Mokni,M, AU - Jerbi,E, AU - Boubaker,S, AU - Ben Osman Dhari,A, AU - Miled,M, PY - 2002/5/4/pubmed PY - 2002/12/17/medline PY - 2002/5/4/entrez SP - 299 EP - 302 JF - Annales de dermatologie et de venereologie JO - Ann Dermatol Venereol VL - 129 IS - 3 N2 - INTRODUCTION: The occurrence of skin damage during systemic amyloidosis is common, but the appearance of bullous lesions is rare. Only twenty-seven cases have been reported in the literature. We report our observation of bullous amyloidosis during progression of renal amyloidosis. OBSERVATION: A 61 year-old man, presented with white, soft, palpebral edemas of the lower limbs, without scutulum involvement, associated with a large cubital nerve that had appeared in March 1997. Biological explorations revealed a nephrotic syndrome. Pathologic study of the renal biopsy concluded in amyloidosis. Treatment with colchinine stabilized the renal damage. One year later, a non-pruriginous, papular and bullous eruption occurred, localized essentially in the axillary and inguinal-crural folds of the forearms and legs. In the presence of an amyloidal deposit and intra-epidermal detachment, the cutaneous biopsy was evocative of bullous amyloidosis. The search for concomitant myeloma was negative. Treatment with colchinine was effective. The bullous lesions disappeared after 2 months, and 21 months later, renal damage was still stable. DISCUSSION: These particularities in evolution are exceptional and have never been described. A hypothetical modification in the physico-chemical properties of the amyloidal protein might explain the bullous eruption and stabilization of renal damage. SN - 0151-9638 UR - https://www.unboundmedicine.com/medline/citation/11988685/[Bullous_amyloidosis]_ L2 - http://www.em-consulte.com/retrieve/pii/MDOI-ad-03-2002-129-3-0151-9638-101019-art6 DB - PRIME DP - Unbound Medicine ER -