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Clinical update on peanut allergy.
Ann Allergy Asthma Immunol 2002; 88(4):350-61; quiz 361-2, 394AA

Abstract

BACKGROUND

Peanut allergy is common, potentially severe, and there has been a recent surge in clinical investigation of this important food allergen.

OBJECTIVE

To provide the reader with a clinically oriented update on peanut allergy.

DATA SOURCES

English language articles were selected from PubMed searches (search terms: peanut allergy, food allergy, anaphylaxis) and selected abstracts with a bias toward recent (3 years) studies judged to have immediate, practical clinical implications.

RESULTS

Peanut allergy is an increasing problem in western diets that include this food. Both genetic and environmental factors influences the expression of this allergy. The at-risk subject is an atopic individual, with heightened risk for those with atopic dermatitis and/or other food allergies. The allergy is long-lived for most, may increase slightly in severity over time, but approximately 20% of young children will develop tolerance. Parameters that may identify the subset likely to achieve tolerance have been identified. Several large studies have determined laboratory parameters (skin tests, peanut-specific serum immunoglobulin E concentrations) with excellent predictive value (>95%) to diagnose current clinical reactivity or tolerance, although oral food challenges are necessary for a definitive diagnosis. Numerous practical lessons concerning management (avoidance, treatment, and prevention) have been identified.

CONCLUSIONS

Recent studies provide the clinician with an armament of improved diagnostic and treatment modalities for peanut allergy. Studies are underway that are likely to provide more definitive therapies in the near future.

Authors+Show Affiliations

The Elliot and Roslyn Jaffe Food Allergy Institute, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029-6574, USA. scott.sicherer@mssm.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

11991552

Citation

Sicherer, Scott H.. "Clinical Update On Peanut Allergy." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 88, no. 4, 2002, pp. 350-61; quiz 361-2, 394.
Sicherer SH. Clinical update on peanut allergy. Ann Allergy Asthma Immunol. 2002;88(4):350-61; quiz 361-2, 394.
Sicherer, S. H. (2002). Clinical update on peanut allergy. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 88(4), pp. 350-61; quiz 361-2, 394.
Sicherer SH. Clinical Update On Peanut Allergy. Ann Allergy Asthma Immunol. 2002;88(4):350-61; quiz 361-2, 394. PubMed PMID: 11991552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical update on peanut allergy. A1 - Sicherer,Scott H, PY - 2002/5/7/pubmed PY - 2002/6/4/medline PY - 2002/5/7/entrez SP - 350-61; quiz 361-2, 394 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 88 IS - 4 N2 - BACKGROUND: Peanut allergy is common, potentially severe, and there has been a recent surge in clinical investigation of this important food allergen. OBJECTIVE: To provide the reader with a clinically oriented update on peanut allergy. DATA SOURCES: English language articles were selected from PubMed searches (search terms: peanut allergy, food allergy, anaphylaxis) and selected abstracts with a bias toward recent (3 years) studies judged to have immediate, practical clinical implications. RESULTS: Peanut allergy is an increasing problem in western diets that include this food. Both genetic and environmental factors influences the expression of this allergy. The at-risk subject is an atopic individual, with heightened risk for those with atopic dermatitis and/or other food allergies. The allergy is long-lived for most, may increase slightly in severity over time, but approximately 20% of young children will develop tolerance. Parameters that may identify the subset likely to achieve tolerance have been identified. Several large studies have determined laboratory parameters (skin tests, peanut-specific serum immunoglobulin E concentrations) with excellent predictive value (>95%) to diagnose current clinical reactivity or tolerance, although oral food challenges are necessary for a definitive diagnosis. Numerous practical lessons concerning management (avoidance, treatment, and prevention) have been identified. CONCLUSIONS: Recent studies provide the clinician with an armament of improved diagnostic and treatment modalities for peanut allergy. Studies are underway that are likely to provide more definitive therapies in the near future. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/11991552/Clinical_update_on_peanut_allergy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)62363-0 DB - PRIME DP - Unbound Medicine ER -