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The early effect of lipid-lowering treatment on carotid and femoral intima media thickness (IMT).
Eur J Vasc Endovasc Surg. 2002 Apr; 23(4):358-64.EJ

Abstract

OBJECTIVES

an increased intima media thickness (IMT) is an early indicator of the atherosclerotic process. We investigated the early effect of atorvastatin on the common carotid artery (CCA) and common femoral artery (CFA) IMT.

METHODS

the IMT was measured in the CCA and the CFA of hyperlipidaemic patients referred with peripheral vascular disease. The measurements were performed using an automated radio frequency IMT technique pre-treatment and at 4 and 8 weeks post-treatment with 20 mg/day atorvastatin.

RESULTS

patients (14 men; 11 women), median age 69 years (range: 48-81) had a CCA-IMT mean (SD) of 0.79 (0.21) mm pre-treatment, 0.75 (0.22) mm after 4 weeks, and 0.64 (0.15) mm after 8 weeks. The ANOVA test was significant (p=0.024) for the CCA-IMT trend. The corresponding CFA-IMT readings were 0.83 (0.13) mm, 0.80 (0.09) mm and 0.69 (0.14) mm (p=0.0003). After 8 weeks of treatment there was a significant reduction in total cholesterol 6.0 (0.3) to 4.3 (0.8) mmol/l, p=0.0004 and low-density lipoprotein cholesterol 3.7 (0.2) to 2.2 (0.5), p=0.0001. There was a significant decrease in median serum creatinine levels after 8 weeks treatment: 87 micromol/l (range 67-114) to 84 micromol/l (range: 64-112), p=0.007.

CONCLUSIONS

cholesterol-lowering with atorvastatin 20 mg/day leads to a decrease in CCA-IMT and CFA-IMT. This difference achieved significance after 8 weeks of treatment, but a trend was visible at 4 weeks. These rapid changes in IMT may be attributable to an anti-inflammatory effect. IMT measurement may be a useful tool to rapidly assess the effect of drug treatment on the atherosclerotic process.

Authors+Show Affiliations

University Department of Surgery, Royal Free Hospital NHS Trust and Royal Free and University College Medical School, University College London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11991700

Citation

Youssef, F, et al. "The Early Effect of Lipid-lowering Treatment On Carotid and Femoral Intima Media Thickness (IMT)." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 23, no. 4, 2002, pp. 358-64.
Youssef F, Seifalian AM, Jagroop IA, et al. The early effect of lipid-lowering treatment on carotid and femoral intima media thickness (IMT). Eur J Vasc Endovasc Surg. 2002;23(4):358-64.
Youssef, F., Seifalian, A. M., Jagroop, I. A., Myint, F., Baker, D., Mikhailidis, D. P., & Hamilton, G. (2002). The early effect of lipid-lowering treatment on carotid and femoral intima media thickness (IMT). European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 23(4), 358-64.
Youssef F, et al. The Early Effect of Lipid-lowering Treatment On Carotid and Femoral Intima Media Thickness (IMT). Eur J Vasc Endovasc Surg. 2002;23(4):358-64. PubMed PMID: 11991700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The early effect of lipid-lowering treatment on carotid and femoral intima media thickness (IMT). AU - Youssef,F, AU - Seifalian,A M, AU - Jagroop,I A, AU - Myint,F, AU - Baker,D, AU - Mikhailidis,D P, AU - Hamilton,G, PY - 2002/5/7/pubmed PY - 2002/7/12/medline PY - 2002/5/7/entrez SP - 358 EP - 64 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 23 IS - 4 N2 - OBJECTIVES: an increased intima media thickness (IMT) is an early indicator of the atherosclerotic process. We investigated the early effect of atorvastatin on the common carotid artery (CCA) and common femoral artery (CFA) IMT. METHODS: the IMT was measured in the CCA and the CFA of hyperlipidaemic patients referred with peripheral vascular disease. The measurements were performed using an automated radio frequency IMT technique pre-treatment and at 4 and 8 weeks post-treatment with 20 mg/day atorvastatin. RESULTS: patients (14 men; 11 women), median age 69 years (range: 48-81) had a CCA-IMT mean (SD) of 0.79 (0.21) mm pre-treatment, 0.75 (0.22) mm after 4 weeks, and 0.64 (0.15) mm after 8 weeks. The ANOVA test was significant (p=0.024) for the CCA-IMT trend. The corresponding CFA-IMT readings were 0.83 (0.13) mm, 0.80 (0.09) mm and 0.69 (0.14) mm (p=0.0003). After 8 weeks of treatment there was a significant reduction in total cholesterol 6.0 (0.3) to 4.3 (0.8) mmol/l, p=0.0004 and low-density lipoprotein cholesterol 3.7 (0.2) to 2.2 (0.5), p=0.0001. There was a significant decrease in median serum creatinine levels after 8 weeks treatment: 87 micromol/l (range 67-114) to 84 micromol/l (range: 64-112), p=0.007. CONCLUSIONS: cholesterol-lowering with atorvastatin 20 mg/day leads to a decrease in CCA-IMT and CFA-IMT. This difference achieved significance after 8 weeks of treatment, but a trend was visible at 4 weeks. These rapid changes in IMT may be attributable to an anti-inflammatory effect. IMT measurement may be a useful tool to rapidly assess the effect of drug treatment on the atherosclerotic process. SN - 1078-5884 UR - https://www.unboundmedicine.com/medline/citation/11991700/The_early_effect_of_lipid_lowering_treatment_on_carotid_and_femoral_intima_media_thickness__IMT__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078588402916114 DB - PRIME DP - Unbound Medicine ER -