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Peripheral blood mononuclear cells from infants hospitalized because of respiratory syncytial virus infection express T helper-1 and T helper-2 cytokines and CC chemokine messenger RNA.
J Infect Dis. 2002 May 15; 185(10):1388-94.JI

Abstract

The cellular immune response to respiratory syncytial virus (RSV) infection was examined in infants aged 1-21 months who were hospitalized because of RSV infection or non-RSV-related illness. RSV- or control-stimulated peripheral blood mononuclear cells were examined to determine RSV-specific intracellular T helper-1 (Th1) and T helper- 2 (Th2) cytokine expression, chemokine messenger RNA (mRNA) expression, and cell surface markers. Patients hospitalized because of RSV infection had increased numbers of CD16(+) and CD56(bright) cells and had RSV-specific increases in Th1 (interleukin [IL]-2 and interferon-gamma) and Th2 (IL-4 and IL-6) cytokines and CC chemokines (macrophage inflammatory protein [MIP]-1alpha, MIP-1beta, and RANTES [regulated on activation, normally T cell expressed and secreted]) mRNA expression. The results suggest that RSV infection induces both Th1 and Th2 cytokine expression and CC chemokine expression.

Authors+Show Affiliations

National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. rgt3@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11992272

Citation

Tripp, Ralph A., et al. "Peripheral Blood Mononuclear Cells From Infants Hospitalized Because of Respiratory Syncytial Virus Infection Express T Helper-1 and T Helper-2 Cytokines and CC Chemokine Messenger RNA." The Journal of Infectious Diseases, vol. 185, no. 10, 2002, pp. 1388-94.
Tripp RA, Moore D, Barskey A, et al. Peripheral blood mononuclear cells from infants hospitalized because of respiratory syncytial virus infection express T helper-1 and T helper-2 cytokines and CC chemokine messenger RNA. J Infect Dis. 2002;185(10):1388-94.
Tripp, R. A., Moore, D., Barskey, A., Jones, L., Moscatiello, C., Keyserling, H., & Anderson, L. J. (2002). Peripheral blood mononuclear cells from infants hospitalized because of respiratory syncytial virus infection express T helper-1 and T helper-2 cytokines and CC chemokine messenger RNA. The Journal of Infectious Diseases, 185(10), 1388-94.
Tripp RA, et al. Peripheral Blood Mononuclear Cells From Infants Hospitalized Because of Respiratory Syncytial Virus Infection Express T Helper-1 and T Helper-2 Cytokines and CC Chemokine Messenger RNA. J Infect Dis. 2002 May 15;185(10):1388-94. PubMed PMID: 11992272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral blood mononuclear cells from infants hospitalized because of respiratory syncytial virus infection express T helper-1 and T helper-2 cytokines and CC chemokine messenger RNA. AU - Tripp,Ralph A, AU - Moore,Deborah, AU - Barskey,Albert,4th AU - Jones,Les, AU - Moscatiello,Caminade, AU - Keyserling,Harry, AU - Anderson,Larry J, Y1 - 2002/04/30/ PY - 2001/11/29/received PY - 2002/01/04/revised PY - 2002/5/7/pubmed PY - 2002/6/18/medline PY - 2002/5/7/entrez SP - 1388 EP - 94 JF - The Journal of infectious diseases JO - J Infect Dis VL - 185 IS - 10 N2 - The cellular immune response to respiratory syncytial virus (RSV) infection was examined in infants aged 1-21 months who were hospitalized because of RSV infection or non-RSV-related illness. RSV- or control-stimulated peripheral blood mononuclear cells were examined to determine RSV-specific intracellular T helper-1 (Th1) and T helper- 2 (Th2) cytokine expression, chemokine messenger RNA (mRNA) expression, and cell surface markers. Patients hospitalized because of RSV infection had increased numbers of CD16(+) and CD56(bright) cells and had RSV-specific increases in Th1 (interleukin [IL]-2 and interferon-gamma) and Th2 (IL-4 and IL-6) cytokines and CC chemokines (macrophage inflammatory protein [MIP]-1alpha, MIP-1beta, and RANTES [regulated on activation, normally T cell expressed and secreted]) mRNA expression. The results suggest that RSV infection induces both Th1 and Th2 cytokine expression and CC chemokine expression. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/11992272/Peripheral_blood_mononuclear_cells_from_infants_hospitalized_because_of_respiratory_syncytial_virus_infection_express_T_helper_1_and_T_helper_2_cytokines_and_CC_chemokine_messenger_RNA_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/340505 DB - PRIME DP - Unbound Medicine ER -