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[Influence of an acute hypercalcemia on the gastric secretion in duodenal ulcer, peptic ulcer of the jejunum and Zollinger-Ellison syndrome].
Z Gesamte Inn Med. 1975 May 15; 30(10):349-53.ZG

Abstract

In 36 patients with ulcer without Zollinger-Ellison-syndrome (25 patients with recurrent duodenal ulcer, 11 with an ulcus pepticum jejuni after B II-resection of the stomach) and 2 patients suffering from ulcus pepticum jejuni with an ascertained gastrinoma the secretion of acid was compared after stimulation of pentagstrin (6 mug/kg) and calcium (4 mg Ca++/kg/h). The secretion of hydrochloric acid was statistically significantly stimulated in all patients suffering from ulcer by the hypercalcaemia (increase of the serum calcium concentration from 5.0 +/- 0.3 mval/1 to 6.2 +/- 0.8 mval/1). But in patients suffering from ulcer with gastrinoma the stimulatory effect was larger than in such patients without autonomous source of gastrin: the calcium-stimulated secretion of hydrochloric acid was on the average in cases of duodenal ulcer 40% (2 to 68%), in the ulcera peptica jejuni 47% (17 to 75%), in the 4 comparative examinations of the two patients with Zollinger-Ellison-syndrome, however, always more than 100% (106 to 177%) of the pentagastrin-stimulated peak secretion. The comparative test of the pentagastrin and calcium-stimulated secretion of hydrochloric acid could be a help for the proof of autonomous places of the formation of gastrin.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

ger

PubMed ID

1199239

Citation

Arendt, R. "[Influence of an Acute Hypercalcemia On the Gastric Secretion in Duodenal Ulcer, Peptic Ulcer of the Jejunum and Zollinger-Ellison Syndrome]." Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete, vol. 30, no. 10, 1975, pp. 349-53.
Arendt R. [Influence of an acute hypercalcemia on the gastric secretion in duodenal ulcer, peptic ulcer of the jejunum and Zollinger-Ellison syndrome]. Z Gesamte Inn Med. 1975;30(10):349-53.
Arendt, R. (1975). [Influence of an acute hypercalcemia on the gastric secretion in duodenal ulcer, peptic ulcer of the jejunum and Zollinger-Ellison syndrome]. Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete, 30(10), 349-53.
Arendt R. [Influence of an Acute Hypercalcemia On the Gastric Secretion in Duodenal Ulcer, Peptic Ulcer of the Jejunum and Zollinger-Ellison Syndrome]. Z Gesamte Inn Med. 1975 May 15;30(10):349-53. PubMed PMID: 1199239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Influence of an acute hypercalcemia on the gastric secretion in duodenal ulcer, peptic ulcer of the jejunum and Zollinger-Ellison syndrome]. A1 - Arendt,R, PY - 1975/5/15/pubmed PY - 1975/5/15/medline PY - 1975/5/15/entrez SP - 349 EP - 53 JF - Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete JO - Z Gesamte Inn Med VL - 30 IS - 10 N2 - In 36 patients with ulcer without Zollinger-Ellison-syndrome (25 patients with recurrent duodenal ulcer, 11 with an ulcus pepticum jejuni after B II-resection of the stomach) and 2 patients suffering from ulcus pepticum jejuni with an ascertained gastrinoma the secretion of acid was compared after stimulation of pentagstrin (6 mug/kg) and calcium (4 mg Ca++/kg/h). The secretion of hydrochloric acid was statistically significantly stimulated in all patients suffering from ulcer by the hypercalcaemia (increase of the serum calcium concentration from 5.0 +/- 0.3 mval/1 to 6.2 +/- 0.8 mval/1). But in patients suffering from ulcer with gastrinoma the stimulatory effect was larger than in such patients without autonomous source of gastrin: the calcium-stimulated secretion of hydrochloric acid was on the average in cases of duodenal ulcer 40% (2 to 68%), in the ulcera peptica jejuni 47% (17 to 75%), in the 4 comparative examinations of the two patients with Zollinger-Ellison-syndrome, however, always more than 100% (106 to 177%) of the pentagastrin-stimulated peak secretion. The comparative test of the pentagastrin and calcium-stimulated secretion of hydrochloric acid could be a help for the proof of autonomous places of the formation of gastrin. SN - 0044-2542 UR - https://www.unboundmedicine.com/medline/citation/1199239/[Influence_of_an_acute_hypercalcemia_on_the_gastric_secretion_in_duodenal_ulcer_peptic_ulcer_of_the_jejunum_and_Zollinger_Ellison_syndrome]_ L2 - http://www.diseaseinfosearch.org/result/7600 DB - PRIME DP - Unbound Medicine ER -