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Genetic study of apolipoprotein E gene, alpha-1 antichymotrypsin gene in sporadic Parkinson disease.
Am J Med Genet. 2002 May 08; 114(4):446-9.AJ

Abstract

Several lines of evidence have suggested some common genetic risk factors for Alzheimer disease (AD) and Parkinson disease (PD) because there are some overlapping pathologies in these two neurodegenerative diseases. In the present study, we investigated the role of Apolipoprotein E gene polymorphism and the signal peptide polymorphism in alpha-1 antichymotrypsin (ACT) gene in idiopathic sporadic PD. The study was performed in a sample consisting of 68 PD cases and 160 healthy subjects in Shanghai China. We found no significant differences of ACT gene polymorphic distribution between PD cases and controls. The ApoE gene epsilon2/epsilon4 genotype was significantly more frequent in PD subjects (chi2 = 7.126, df = 1, P = 0.008) and conferred a 12.70 times susceptibility for PD (OR = 12.62, 95% CI: 1.445-110.17, chi2 = 5.259, P < 0.05, AF = 4.59%). No interaction of ApoE and ACT genes was detected in PD. Therefore, our data suggested that the ApoE epsilon2/epsilon4 genotype might be a susceptibility variant of moderate effect for sporadic idiopathic PD in our samples, whereas the ACT gene signal peptide polymorphism might not.

Authors+Show Affiliations

State Key Lab of Genetic Engineering, Institute of Genetics, Fudan University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11992569

Citation

Tang, Guomei, et al. "Genetic Study of Apolipoprotein E Gene, Alpha-1 Antichymotrypsin Gene in Sporadic Parkinson Disease." American Journal of Medical Genetics, vol. 114, no. 4, 2002, pp. 446-9.
Tang G, Xie H, Xu L, et al. Genetic study of apolipoprotein E gene, alpha-1 antichymotrypsin gene in sporadic Parkinson disease. Am J Med Genet. 2002;114(4):446-9.
Tang, G., Xie, H., Xu, L., Hao, Y., Lin, D., & Ren, D. (2002). Genetic study of apolipoprotein E gene, alpha-1 antichymotrypsin gene in sporadic Parkinson disease. American Journal of Medical Genetics, 114(4), 446-9.
Tang G, et al. Genetic Study of Apolipoprotein E Gene, Alpha-1 Antichymotrypsin Gene in Sporadic Parkinson Disease. Am J Med Genet. 2002 May 8;114(4):446-9. PubMed PMID: 11992569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic study of apolipoprotein E gene, alpha-1 antichymotrypsin gene in sporadic Parkinson disease. AU - Tang,Guomei, AU - Xie,Huijun, AU - Xu,Lin, AU - Hao,Yixin, AU - Lin,Dayu, AU - Ren,Daming, PY - 2002/5/7/pubmed PY - 2002/9/28/medline PY - 2002/5/7/entrez SP - 446 EP - 9 JF - American journal of medical genetics JO - Am J Med Genet VL - 114 IS - 4 N2 - Several lines of evidence have suggested some common genetic risk factors for Alzheimer disease (AD) and Parkinson disease (PD) because there are some overlapping pathologies in these two neurodegenerative diseases. In the present study, we investigated the role of Apolipoprotein E gene polymorphism and the signal peptide polymorphism in alpha-1 antichymotrypsin (ACT) gene in idiopathic sporadic PD. The study was performed in a sample consisting of 68 PD cases and 160 healthy subjects in Shanghai China. We found no significant differences of ACT gene polymorphic distribution between PD cases and controls. The ApoE gene epsilon2/epsilon4 genotype was significantly more frequent in PD subjects (chi2 = 7.126, df = 1, P = 0.008) and conferred a 12.70 times susceptibility for PD (OR = 12.62, 95% CI: 1.445-110.17, chi2 = 5.259, P < 0.05, AF = 4.59%). No interaction of ApoE and ACT genes was detected in PD. Therefore, our data suggested that the ApoE epsilon2/epsilon4 genotype might be a susceptibility variant of moderate effect for sporadic idiopathic PD in our samples, whereas the ACT gene signal peptide polymorphism might not. SN - 0148-7299 UR - https://www.unboundmedicine.com/medline/citation/11992569/Genetic_study_of_apolipoprotein_E_gene_alpha_1_antichymotrypsin_gene_in_sporadic_Parkinson_disease_ DB - PRIME DP - Unbound Medicine ER -