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Three-layer guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride.
J Control Release. 2002 May 17; 81(1-2):45-56.JC

Abstract

The present study is carried out to design oral controlled drug delivery systems for highly water-soluble drugs using guar gum as a carrier in the form of three-layer matrix tablets. Trimetazidine dihydrochloride was chosen as a model drug because of its high water solubility. Matrix tablet granules containing 30% (M1), 40% (M2) or 50% (M3) of guar gum were prepared by the wet granulation technique using starch paste as a binder. Three-layer matrix tablets of trimetazidine dihydrochloride were prepared by compressing on either side of guar gum matrix tablet granules of trimetazidine dihydrochloride M1, M2 or M3 with 200 mg of guar gum granules containing either 65% of guar gum (T1M1, T1M2 or T1M3), 75% of guar gum (T2M1, T2M2 or T2M3) or 85% of guar gum (T3M1, T3M2 or T3M3) as release retardant layers. The three-layer matrix tablets were evaluated for hardness, thickness, drug content uniformity, and were subjected to in vitro drug release studies. The amount of trimetazidine dihydrochloride released from the matrix and three-layer matrix tablets at different time intervals was estimated using a HPLC method. The three-layer guar gum matrix tablet (T3M3) provided the required release rate on par with the theoretical release rate for guar gum formulations meant for twice daily administration. The three-layer guar gum matrix tablet (T3M3) showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40 degrees C/RH 75% for 6 months. The DSC study did not show any possibility of interaction between trimetazidine dihydrochloride and guar gum/other formulation excipients used in the study. The results indicated that guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as trimetazidine dihydrochloride.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, College of Engineering, Andhra University, 530-003, Visakhapatnam, India. krishnaysr112@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11992677

Citation

Krishnaiah, Y S R., et al. "Three-layer Guar Gum Matrix Tablet Formulations for Oral Controlled Delivery of Highly Soluble Trimetazidine Dihydrochloride." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 81, no. 1-2, 2002, pp. 45-56.
Krishnaiah YS, Karthikeyan RS, Gouri Sankar V, et al. Three-layer guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride. J Control Release. 2002;81(1-2):45-56.
Krishnaiah, Y. S., Karthikeyan, R. S., Gouri Sankar, V., & Satyanarayana, V. (2002). Three-layer guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride. Journal of Controlled Release : Official Journal of the Controlled Release Society, 81(1-2), 45-56.
Krishnaiah YS, et al. Three-layer Guar Gum Matrix Tablet Formulations for Oral Controlled Delivery of Highly Soluble Trimetazidine Dihydrochloride. J Control Release. 2002 May 17;81(1-2):45-56. PubMed PMID: 11992677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-layer guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride. AU - Krishnaiah,Y S R, AU - Karthikeyan,R S, AU - Gouri Sankar,V, AU - Satyanarayana,V, PY - 2002/5/7/pubmed PY - 2002/8/6/medline PY - 2002/5/7/entrez SP - 45 EP - 56 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 81 IS - 1-2 N2 - The present study is carried out to design oral controlled drug delivery systems for highly water-soluble drugs using guar gum as a carrier in the form of three-layer matrix tablets. Trimetazidine dihydrochloride was chosen as a model drug because of its high water solubility. Matrix tablet granules containing 30% (M1), 40% (M2) or 50% (M3) of guar gum were prepared by the wet granulation technique using starch paste as a binder. Three-layer matrix tablets of trimetazidine dihydrochloride were prepared by compressing on either side of guar gum matrix tablet granules of trimetazidine dihydrochloride M1, M2 or M3 with 200 mg of guar gum granules containing either 65% of guar gum (T1M1, T1M2 or T1M3), 75% of guar gum (T2M1, T2M2 or T2M3) or 85% of guar gum (T3M1, T3M2 or T3M3) as release retardant layers. The three-layer matrix tablets were evaluated for hardness, thickness, drug content uniformity, and were subjected to in vitro drug release studies. The amount of trimetazidine dihydrochloride released from the matrix and three-layer matrix tablets at different time intervals was estimated using a HPLC method. The three-layer guar gum matrix tablet (T3M3) provided the required release rate on par with the theoretical release rate for guar gum formulations meant for twice daily administration. The three-layer guar gum matrix tablet (T3M3) showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40 degrees C/RH 75% for 6 months. The DSC study did not show any possibility of interaction between trimetazidine dihydrochloride and guar gum/other formulation excipients used in the study. The results indicated that guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as trimetazidine dihydrochloride. SN - 0168-3659 UR - https://www.unboundmedicine.com/medline/citation/11992677/Three_layer_guar_gum_matrix_tablet_formulations_for_oral_controlled_delivery_of_highly_soluble_trimetazidine_dihydrochloride_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168365902000317 DB - PRIME DP - Unbound Medicine ER -