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A double-blind placebo-controlled evaluation of the acute effects of sildenafil citrate (Viagra) on visual function in subjects with early-stage age-related macular degeneration.
Am J Ophthalmol. 2002 May; 133(5):665-72.AJ

Abstract

PURPOSE

To assess the effects of a single 100-mg dose of sildenafil citrate on visual function in men with early-stage age-related macular degeneration.

DESIGN

Randomized double-blind placebo-controlled clinical trial.

METHODS

Nine men (mean age 71 years, range 59-85 years) with early-stage (minimal visual impairment and large drusen in the macula) age-related macular degeneration and 20/40 or better-corrected visual acuity in at least one eye were prospectively randomized to receive either placebo or sildenafil citrate (Viagra; Pfizer Inc, New York, New York) 100 mg as a single oral dose. After 7-14 days, they received the alternate treatment. Subjects underwent visual acuity, Amsler grid, color discrimination (D15), traffic light, Humphrey perimetry, and photo-stress testing in each eye before and at specific intervals within 8 hours after dosing.

RESULTS

Compared with placebo, no pattern of errors were evident in any visual function test following sildenafil administration. No statistically or clinically relevant changes from baseline were observed in visual acuity, Humphrey perimetry (corrected pattern standard deviation), D15 color discrimination, or photo-stress tests. No clinically relevant changes were observed in the Amsler grid or traffic light tests. Sildenafil treatment was associated with transient mild or moderate headache, flushing, and rhinitis. There were no visual adverse events spontaneously reported to the investigator.

CONCLUSION

A single 100-mg dose of sildenafil was well tolerated and produced no acute visual effects or exacerbation of preexisting visual impairment in nine men with early-stage age-related macular degeneration.

Authors+Show Affiliations

Retina Foundation of the Southwest, Dallas, Texas 75231, USA. dbirch@retinafoundation.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11992864

Citation

Birch, David G., et al. "A Double-blind Placebo-controlled Evaluation of the Acute Effects of Sildenafil Citrate (Viagra) On Visual Function in Subjects With Early-stage Age-related Macular Degeneration." American Journal of Ophthalmology, vol. 133, no. 5, 2002, pp. 665-72.
Birch DG, Toler SM, Swanson WH, et al. A double-blind placebo-controlled evaluation of the acute effects of sildenafil citrate (Viagra) on visual function in subjects with early-stage age-related macular degeneration. Am J Ophthalmol. 2002;133(5):665-72.
Birch, D. G., Toler, S. M., Swanson, W. H., Fish, G. E., & Laties, A. M. (2002). A double-blind placebo-controlled evaluation of the acute effects of sildenafil citrate (Viagra) on visual function in subjects with early-stage age-related macular degeneration. American Journal of Ophthalmology, 133(5), 665-72.
Birch DG, et al. A Double-blind Placebo-controlled Evaluation of the Acute Effects of Sildenafil Citrate (Viagra) On Visual Function in Subjects With Early-stage Age-related Macular Degeneration. Am J Ophthalmol. 2002;133(5):665-72. PubMed PMID: 11992864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A double-blind placebo-controlled evaluation of the acute effects of sildenafil citrate (Viagra) on visual function in subjects with early-stage age-related macular degeneration. AU - Birch,David G, AU - Toler,Steven M, AU - Swanson,William H, AU - Fish,Gary E, AU - Laties,Alan M, PY - 2002/5/7/pubmed PY - 2002/6/14/medline PY - 2002/5/7/entrez SP - 665 EP - 72 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 133 IS - 5 N2 - PURPOSE: To assess the effects of a single 100-mg dose of sildenafil citrate on visual function in men with early-stage age-related macular degeneration. DESIGN: Randomized double-blind placebo-controlled clinical trial. METHODS: Nine men (mean age 71 years, range 59-85 years) with early-stage (minimal visual impairment and large drusen in the macula) age-related macular degeneration and 20/40 or better-corrected visual acuity in at least one eye were prospectively randomized to receive either placebo or sildenafil citrate (Viagra; Pfizer Inc, New York, New York) 100 mg as a single oral dose. After 7-14 days, they received the alternate treatment. Subjects underwent visual acuity, Amsler grid, color discrimination (D15), traffic light, Humphrey perimetry, and photo-stress testing in each eye before and at specific intervals within 8 hours after dosing. RESULTS: Compared with placebo, no pattern of errors were evident in any visual function test following sildenafil administration. No statistically or clinically relevant changes from baseline were observed in visual acuity, Humphrey perimetry (corrected pattern standard deviation), D15 color discrimination, or photo-stress tests. No clinically relevant changes were observed in the Amsler grid or traffic light tests. Sildenafil treatment was associated with transient mild or moderate headache, flushing, and rhinitis. There were no visual adverse events spontaneously reported to the investigator. CONCLUSION: A single 100-mg dose of sildenafil was well tolerated and produced no acute visual effects or exacerbation of preexisting visual impairment in nine men with early-stage age-related macular degeneration. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/11992864/A_double_blind_placebo_controlled_evaluation_of_the_acute_effects_of_sildenafil_citrate__Viagra__on_visual_function_in_subjects_with_early_stage_age_related_macular_degeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002939402013387 DB - PRIME DP - Unbound Medicine ER -