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Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats.
Singapore Med J. 2002 Feb; 43(2):077-85.SM

Abstract

AIM OF STUDY

The aim was to investigate the hypoglycemic and anti-oxidant activities of the dried roots of Morinda officinalis in streptozotocin-induced diabetic rats.

METHODOLOGY

An ethanolic extract of the dried roots of Morinda officinalis and its three fractions (ethyl acetate, n-butanol and water) were obtained. We evaluated the hypoglycemic effects of three different single doses of the crude extract and its fractions in normal and diabetic rats for three hours after administration. Administration of the extract at 150 mg/kg twice daily for 10 days to the diabetic rats was also carried out. The effects of the 10-day treatment on the fasting serum glucose, insulin, total cholesterol, triglycerides, body weight, food intake, fluid intake, hepatic superoxide dismutase (SOD), catalase (CAT) activities, reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and renal TBARS levels were monitored.

RESULTS

In the three-hour dose response study, the crude ethanolic extract reduced the fasting serum glucose levels of the diabetic rats significantly at 150 mg/kg but increased those of the normal rats significantly at 600 mg/kg only. The water fraction demonstrated a dose dependent hypoglycemic effect in the diabetic rats whereas the n-butanol fraction increased the fasting serum glucose levels of the diabetic rats significantly at 50 mg/kg only within three hours after administration. The 10-day oral administration of the extract reduced the fasting serum glucose, hepatic and renal TBARS level and significantly increased the hepatic SOD and CAT activities as well as GSH levels.

CONCLUSION

The results indicate that the dried roots of Morinda officinalis possess hypoglycemic, hyperglycemic and anti-oxidant properties.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine National University of Singapore, Singapore.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11993894

Citation

Soon, Y Y., and B K H. Tan. "Evaluation of the Hypoglycemic and Anti-oxidant Activities of Morinda Officinalis in Streptozotocin-induced Diabetic Rats." Singapore Medical Journal, vol. 43, no. 2, 2002, pp. 077-85.
Soon YY, Tan BK. Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. Singapore Med J. 2002;43(2):077-85.
Soon, Y. Y., & Tan, B. K. (2002). Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. Singapore Medical Journal, 43(2), 077-85.
Soon YY, Tan BK. Evaluation of the Hypoglycemic and Anti-oxidant Activities of Morinda Officinalis in Streptozotocin-induced Diabetic Rats. Singapore Med J. 2002;43(2):077-85. PubMed PMID: 11993894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. AU - Soon,Y Y, AU - Tan,B K H, PY - 2002/5/8/pubmed PY - 2002/6/6/medline PY - 2002/5/8/entrez SP - 077 EP - 85 JF - Singapore medical journal JO - Singapore Med J VL - 43 IS - 2 N2 - AIM OF STUDY: The aim was to investigate the hypoglycemic and anti-oxidant activities of the dried roots of Morinda officinalis in streptozotocin-induced diabetic rats. METHODOLOGY: An ethanolic extract of the dried roots of Morinda officinalis and its three fractions (ethyl acetate, n-butanol and water) were obtained. We evaluated the hypoglycemic effects of three different single doses of the crude extract and its fractions in normal and diabetic rats for three hours after administration. Administration of the extract at 150 mg/kg twice daily for 10 days to the diabetic rats was also carried out. The effects of the 10-day treatment on the fasting serum glucose, insulin, total cholesterol, triglycerides, body weight, food intake, fluid intake, hepatic superoxide dismutase (SOD), catalase (CAT) activities, reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and renal TBARS levels were monitored. RESULTS: In the three-hour dose response study, the crude ethanolic extract reduced the fasting serum glucose levels of the diabetic rats significantly at 150 mg/kg but increased those of the normal rats significantly at 600 mg/kg only. The water fraction demonstrated a dose dependent hypoglycemic effect in the diabetic rats whereas the n-butanol fraction increased the fasting serum glucose levels of the diabetic rats significantly at 50 mg/kg only within three hours after administration. The 10-day oral administration of the extract reduced the fasting serum glucose, hepatic and renal TBARS level and significantly increased the hepatic SOD and CAT activities as well as GSH levels. CONCLUSION: The results indicate that the dried roots of Morinda officinalis possess hypoglycemic, hyperglycemic and anti-oxidant properties. SN - 0037-5675 UR - https://www.unboundmedicine.com/medline/citation/11993894/Evaluation_of_the_hypoglycemic_and_anti_oxidant_activities_of_Morinda_officinalis_in_streptozotocin_induced_diabetic_rats_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -