Tags

Type your tag names separated by a space and hit enter

The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications.
CNS Drugs. 2002; 16(5):339-52.CD

Abstract

Abnormalities in the metabolism of the transition metals iron and copper have been demonstrated to play a crucial role in the pathogenesis of various neurodegenerative diseases. Metal homeostasis as it pertains to alterations in brain function in neurodegenerative diseases is reviewed in this article in depth. While there is documented evidence for alterations in the homeostasis, redox-activity and localisation of transition metals, it is also important to realise that alterations in specific copper- and iron-containing metalloenzymes appear to play a crucial role in the neurodegenerative process. These changes provide the opportunity to identify pathways where modification of the disease process can occur, potentially offering opportunities for clinical intervention. As understanding of disease aetiology evolves, so do the tools with which diseases are treated. In this article, we examine not only the possible mechanism of disease but also how pharmaceuticals may intervene, from direct and indirect antioxidant therapy to strategies involving gene therapy.

Authors+Show Affiliations

Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA. gxp@po.cwru.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

11994023

Citation

Perry, George, et al. "The Role of Iron and Copper in the Aetiology of Neurodegenerative Disorders: Therapeutic Implications." CNS Drugs, vol. 16, no. 5, 2002, pp. 339-52.
Perry G, Sayre LM, Atwood CS, et al. The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications. CNS Drugs. 2002;16(5):339-52.
Perry, G., Sayre, L. M., Atwood, C. S., Castellani, R. J., Cash, A. D., Rottkamp, C. A., & Smith, M. A. (2002). The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications. CNS Drugs, 16(5), 339-52.
Perry G, et al. The Role of Iron and Copper in the Aetiology of Neurodegenerative Disorders: Therapeutic Implications. CNS Drugs. 2002;16(5):339-52. PubMed PMID: 11994023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications. AU - Perry,George, AU - Sayre,Lawrence M, AU - Atwood,Craig S, AU - Castellani,Rudolph J, AU - Cash,Adam D, AU - Rottkamp,Catherine A, AU - Smith,Mark A, PY - 2002/5/8/pubmed PY - 2002/7/24/medline PY - 2002/5/8/entrez SP - 339 EP - 52 JF - CNS drugs JO - CNS Drugs VL - 16 IS - 5 N2 - Abnormalities in the metabolism of the transition metals iron and copper have been demonstrated to play a crucial role in the pathogenesis of various neurodegenerative diseases. Metal homeostasis as it pertains to alterations in brain function in neurodegenerative diseases is reviewed in this article in depth. While there is documented evidence for alterations in the homeostasis, redox-activity and localisation of transition metals, it is also important to realise that alterations in specific copper- and iron-containing metalloenzymes appear to play a crucial role in the neurodegenerative process. These changes provide the opportunity to identify pathways where modification of the disease process can occur, potentially offering opportunities for clinical intervention. As understanding of disease aetiology evolves, so do the tools with which diseases are treated. In this article, we examine not only the possible mechanism of disease but also how pharmaceuticals may intervene, from direct and indirect antioxidant therapy to strategies involving gene therapy. SN - 1172-7047 UR - https://www.unboundmedicine.com/medline/citation/11994023/The_role_of_iron_and_copper_in_the_aetiology_of_neurodegenerative_disorders:_therapeutic_implications_ L2 - https://dx.doi.org/10.2165/00023210-200216050-00006 DB - PRIME DP - Unbound Medicine ER -