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Prognostic factors of intrahepatic cholangiocarcinoma after hepatic resection: univariate and multivariate analysis.
Hepatogastroenterology. 2002 Mar-Apr; 49(44):311-6.H

Abstract

BACKGROUND/AIMS

Intrahepatic cholangiocarcinoma is clinicopathologically distinct from hepatocellular carcinoma and hilar cholangiocarcinoma, and the prognostic factors after hepatic resection of these rare tumors are not well documented. The aim of this study was to evaluate prognostic factors of intrahepatic cholangiocarcinoma after hepatic resection.

METHODOLOGY

We retrospectively studied 20 consecutive patients with intrahepatic cholangiocarcinoma who underwent hepatectomy over a 15-year period from 1984 to 1998. Fifteen prognostic factors were evaluated for their association with overall and disease-free survivals in univariate and multivariate analysis (Cox's proportional hazards model).

RESULTS

Eighty percent of the resected patients had major hepatectomy. Operative morbidity and mortality rates were 30% and 0%, respectively. Four patients (20%) survived more than 5 years without recurrence after hepatic resection. The 1-year, 3-year, and 5-year overall or disease-free survival rate after hepatic resection were 56.0% or 49.5%, 43.8% or 43.3%, and 43.8% or 37.3%, respectively. Univariate analysis showed young age and periductal invasion tumor or the presence of vascular invasion, lymphatic invasion, and lymph node metastasis as significant poor prognostic predictors contributing overall and disease-free survivals. Multivariate analysis revealed only lymph node metastasis as an independent prognostic factor affecting disease-free survival. During the same time, 17 unresectable patients were treated by intrahepatic arterial infusion chemotherapy (12), systemic chemotherapy (4), or radiation (1). Median overall survival time in resected patients (16 months) was significantly better than in unresectable patients (5 months) (P = 0.005).

CONCLUSIONS

Hepatic resection remains to be the best current therapeutic option. The prognosis after hepatic resection for intrahepatic cholangiocarcinoma was determined by lymph node metastasis. New adjuvant chemotherapy after surgery is imperative for such patients.

Authors+Show Affiliations

Second Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. hanayan@hsp.md.shinshu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11995440

Citation

Hanazaki, Kazuhiro, et al. "Prognostic Factors of Intrahepatic Cholangiocarcinoma After Hepatic Resection: Univariate and Multivariate Analysis." Hepato-gastroenterology, vol. 49, no. 44, 2002, pp. 311-6.
Hanazaki K, Kajikawa S, Shimozawa N, et al. Prognostic factors of intrahepatic cholangiocarcinoma after hepatic resection: univariate and multivariate analysis. Hepatogastroenterology. 2002;49(44):311-6.
Hanazaki, K., Kajikawa, S., Shimozawa, N., Shimada, K., Hiraguri, M., Koide, N., Adachi, W., & Amano, J. (2002). Prognostic factors of intrahepatic cholangiocarcinoma after hepatic resection: univariate and multivariate analysis. Hepato-gastroenterology, 49(44), 311-6.
Hanazaki K, et al. Prognostic Factors of Intrahepatic Cholangiocarcinoma After Hepatic Resection: Univariate and Multivariate Analysis. Hepatogastroenterology. 2002 Mar-Apr;49(44):311-6. PubMed PMID: 11995440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic factors of intrahepatic cholangiocarcinoma after hepatic resection: univariate and multivariate analysis. AU - Hanazaki,Kazuhiro, AU - Kajikawa,Shoji, AU - Shimozawa,Nobuhiko, AU - Shimada,Ko, AU - Hiraguri,Manabu, AU - Koide,Naohiko, AU - Adachi,Wataru, AU - Amano,Jun, PY - 2002/5/9/pubmed PY - 2002/12/4/medline PY - 2002/5/9/entrez SP - 311 EP - 6 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 49 IS - 44 N2 - BACKGROUND/AIMS: Intrahepatic cholangiocarcinoma is clinicopathologically distinct from hepatocellular carcinoma and hilar cholangiocarcinoma, and the prognostic factors after hepatic resection of these rare tumors are not well documented. The aim of this study was to evaluate prognostic factors of intrahepatic cholangiocarcinoma after hepatic resection. METHODOLOGY: We retrospectively studied 20 consecutive patients with intrahepatic cholangiocarcinoma who underwent hepatectomy over a 15-year period from 1984 to 1998. Fifteen prognostic factors were evaluated for their association with overall and disease-free survivals in univariate and multivariate analysis (Cox's proportional hazards model). RESULTS: Eighty percent of the resected patients had major hepatectomy. Operative morbidity and mortality rates were 30% and 0%, respectively. Four patients (20%) survived more than 5 years without recurrence after hepatic resection. The 1-year, 3-year, and 5-year overall or disease-free survival rate after hepatic resection were 56.0% or 49.5%, 43.8% or 43.3%, and 43.8% or 37.3%, respectively. Univariate analysis showed young age and periductal invasion tumor or the presence of vascular invasion, lymphatic invasion, and lymph node metastasis as significant poor prognostic predictors contributing overall and disease-free survivals. Multivariate analysis revealed only lymph node metastasis as an independent prognostic factor affecting disease-free survival. During the same time, 17 unresectable patients were treated by intrahepatic arterial infusion chemotherapy (12), systemic chemotherapy (4), or radiation (1). Median overall survival time in resected patients (16 months) was significantly better than in unresectable patients (5 months) (P = 0.005). CONCLUSIONS: Hepatic resection remains to be the best current therapeutic option. The prognosis after hepatic resection for intrahepatic cholangiocarcinoma was determined by lymph node metastasis. New adjuvant chemotherapy after surgery is imperative for such patients. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/11995440/Prognostic_factors_of_intrahepatic_cholangiocarcinoma_after_hepatic_resection:_univariate_and_multivariate_analysis_ L2 - https://www.diseaseinfosearch.org/result/3854 DB - PRIME DP - Unbound Medicine ER -