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Neurotoxic lesions of the rat perirhinal cortex fail to disrupt the acquisition or performance of tests of allocentric spatial memory.
Behav Neurosci. 2002 Apr; 116(2):232-40.BN

Abstract

Rats with neurotoxic lesions of the perirhinal cortex (n = 9) were compared with sham controls (n = 14) on a working memory task in the radial arm maze. Rats were trained under varying levels of proactive interference and with different retention intervals. Finally, performance was assessed when the maze was switched to a novel room. None of these manipulations differentially impaired rats with perirhinal lesions. Rats were next trained on delayed matching-to-place in the water maze. Even with retention delays of 30 min, there was no evidence of a deficit. Although interactions between the perirhinal cortex and hippocampus may be important for integrating object-place information, the perirhinal cortex is often not necessary for tasks that selectively tax allocentric spatial memory.

Authors+Show Affiliations

School of Psychology, Cardiff University, Wales.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11996309

Citation

Machin, P, et al. "Neurotoxic Lesions of the Rat Perirhinal Cortex Fail to Disrupt the Acquisition or Performance of Tests of Allocentric Spatial Memory." Behavioral Neuroscience, vol. 116, no. 2, 2002, pp. 232-40.
Machin P, Vann SD, Muir JL, et al. Neurotoxic lesions of the rat perirhinal cortex fail to disrupt the acquisition or performance of tests of allocentric spatial memory. Behav Neurosci. 2002;116(2):232-40.
Machin, P., Vann, S. D., Muir, J. L., & Aggleton, J. P. (2002). Neurotoxic lesions of the rat perirhinal cortex fail to disrupt the acquisition or performance of tests of allocentric spatial memory. Behavioral Neuroscience, 116(2), 232-40.
Machin P, et al. Neurotoxic Lesions of the Rat Perirhinal Cortex Fail to Disrupt the Acquisition or Performance of Tests of Allocentric Spatial Memory. Behav Neurosci. 2002;116(2):232-40. PubMed PMID: 11996309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurotoxic lesions of the rat perirhinal cortex fail to disrupt the acquisition or performance of tests of allocentric spatial memory. AU - Machin,P, AU - Vann,S D, AU - Muir,J L, AU - Aggleton,J P, PY - 2002/5/9/pubmed PY - 2002/10/31/medline PY - 2002/5/9/entrez SP - 232 EP - 40 JF - Behavioral neuroscience JO - Behav Neurosci VL - 116 IS - 2 N2 - Rats with neurotoxic lesions of the perirhinal cortex (n = 9) were compared with sham controls (n = 14) on a working memory task in the radial arm maze. Rats were trained under varying levels of proactive interference and with different retention intervals. Finally, performance was assessed when the maze was switched to a novel room. None of these manipulations differentially impaired rats with perirhinal lesions. Rats were next trained on delayed matching-to-place in the water maze. Even with retention delays of 30 min, there was no evidence of a deficit. Although interactions between the perirhinal cortex and hippocampus may be important for integrating object-place information, the perirhinal cortex is often not necessary for tasks that selectively tax allocentric spatial memory. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/11996309/Neurotoxic_lesions_of_the_rat_perirhinal_cortex_fail_to_disrupt_the_acquisition_or_performance_of_tests_of_allocentric_spatial_memory_ L2 - http://content.apa.org/journals/bne/116/2/232 DB - PRIME DP - Unbound Medicine ER -