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[Diffuse sclerosing osteomyelitis of the mandible and SAPHO syndrome].
Rev Stomatol Chir Maxillofac 2002; 103(2):96-104RS

Abstract

BACKGROUND

Diffuse sclerosing osteomyelitis of the mandible (DSOM) and SAPHO (synovitis, acne, palmo-plantar pustulosis and psoriasis, hyperosteosis, osteitis) syndrome are not commonly associated. SAPHO has not been described to date in the stomatology and maxillo-facial surgery literature in French. Were report here a homogeneous series of 12 patients with DSOM.

MATERIAL AND METHODS

All patients had mandibular osteitis.

RESULTS

Five patients with multifocal osteitis wre considered to present SAPHO syndrome because of the associated skin lesions. One patient with a unique focus of mandibular osteitis and palmo-plantar pustulosis probably had early-stage SAPHO syndrome. The diagnosis in the other cases was diffuse sclerosis osteitis of the mandible.

DISCUSSION

We compared our series with those reported in the literature, emphasizing diagnostic and therapeutic difficulties. Diffuse sclerosing osteomyelitis of the mandible should be distinguished from microbial osteitis. Early diagnosis is required to avoid successive and unnecessary dental avulsions. There is a possible link between DSOM and SAPHO and all patients should have a complete work-up including whole-body scintigraphy to search for other foci. A biopsy is indicated to rule out malignancy. Nonsteroidal antiinflammatory drugs can improve patient comfort in this particularly long syndrome. Although the efficacy is demonstrated, surgery and antibiotics can only delay relapse for a few months.

Authors+Show Affiliations

U.F.R. de Stomatologie et Chirurgie Maxillo-faciale, Groupe Hospitalier Pitié Salpêtrière, 47, Bd de l'Hôpital, 75013 Paris.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Comparative Study
English Abstract
Journal Article
Review

Language

fre

PubMed ID

11997737

Citation

Fleuridas, G, et al. "[Diffuse Sclerosing Osteomyelitis of the Mandible and SAPHO Syndrome]." Revue De Stomatologie Et De Chirurgie Maxillo-faciale, vol. 103, no. 2, 2002, pp. 96-104.
Fleuridas G, Teysseres N, Ragot JP, et al. [Diffuse sclerosing osteomyelitis of the mandible and SAPHO syndrome]. Rev Stomatol Chir Maxillofac. 2002;103(2):96-104.
Fleuridas, G., Teysseres, N., Ragot, J. P., Chikhani, L., & Favre-Dauvergne, E. (2002). [Diffuse sclerosing osteomyelitis of the mandible and SAPHO syndrome]. Revue De Stomatologie Et De Chirurgie Maxillo-faciale, 103(2), pp. 96-104.
Fleuridas G, et al. [Diffuse Sclerosing Osteomyelitis of the Mandible and SAPHO Syndrome]. Rev Stomatol Chir Maxillofac. 2002;103(2):96-104. PubMed PMID: 11997737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diffuse sclerosing osteomyelitis of the mandible and SAPHO syndrome]. AU - Fleuridas,G, AU - Teysseres,N, AU - Ragot,J P, AU - Chikhani,L, AU - Favre-Dauvergne,E, PY - 2002/5/9/pubmed PY - 2002/7/20/medline PY - 2002/5/9/entrez SP - 96 EP - 104 JF - Revue de stomatologie et de chirurgie maxillo-faciale JO - Rev Stomatol Chir Maxillofac VL - 103 IS - 2 N2 - BACKGROUND: Diffuse sclerosing osteomyelitis of the mandible (DSOM) and SAPHO (synovitis, acne, palmo-plantar pustulosis and psoriasis, hyperosteosis, osteitis) syndrome are not commonly associated. SAPHO has not been described to date in the stomatology and maxillo-facial surgery literature in French. Were report here a homogeneous series of 12 patients with DSOM. MATERIAL AND METHODS: All patients had mandibular osteitis. RESULTS: Five patients with multifocal osteitis wre considered to present SAPHO syndrome because of the associated skin lesions. One patient with a unique focus of mandibular osteitis and palmo-plantar pustulosis probably had early-stage SAPHO syndrome. The diagnosis in the other cases was diffuse sclerosis osteitis of the mandible. DISCUSSION: We compared our series with those reported in the literature, emphasizing diagnostic and therapeutic difficulties. Diffuse sclerosing osteomyelitis of the mandible should be distinguished from microbial osteitis. Early diagnosis is required to avoid successive and unnecessary dental avulsions. There is a possible link between DSOM and SAPHO and all patients should have a complete work-up including whole-body scintigraphy to search for other foci. A biopsy is indicated to rule out malignancy. Nonsteroidal antiinflammatory drugs can improve patient comfort in this particularly long syndrome. Although the efficacy is demonstrated, surgery and antibiotics can only delay relapse for a few months. SN - 0035-1768 UR - https://www.unboundmedicine.com/medline/citation/11997737/[Diffuse_sclerosing_osteomyelitis_of_the_mandible_and_SAPHO_syndrome]_ L2 - http://www.diseaseinfosearch.org/result/6411 DB - PRIME DP - Unbound Medicine ER -