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Post-training reversible inactivation of hippocampus reveals interference between memory systems.
Hippocampus. 2002; 12(2):280-4.H

Abstract

A post-training reversible lesion technique was used to examine the effects of neural inactivation of the dorsal hippocampus on place and response learning. Male Long-Evans rats trained in one of two versions of a water plus-maze task received post-training intra-hippocampal infusions of the local anesthetic drug bupivacaine (0.75% solution, 0.5 microl), or saline. Post-training intra-hippocampal infusions of bupivacaine attenuated acquisition of the place task and enhanced acquisition of the response task. Delayed (2-h) post-training infusions of bupivacaine did not affect retention in either task. The findings demonstrate (1) enhanced learning after reversible hippocampal lesions that is independent of treatment influences on non-mnemonic factors, and (2) inactivation of the dorsal hippocampus during the post-training memory consolidation period is sufficient to enhance response learning.

Authors+Show Affiliations

Department of Psychology, Yale University, New Haven, Connecticut 06520-8025, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12000124

Citation

Schroeder, Jason P., et al. "Post-training Reversible Inactivation of Hippocampus Reveals Interference Between Memory Systems." Hippocampus, vol. 12, no. 2, 2002, pp. 280-4.
Schroeder JP, Wingard JC, Packard MG. Post-training reversible inactivation of hippocampus reveals interference between memory systems. Hippocampus. 2002;12(2):280-4.
Schroeder, J. P., Wingard, J. C., & Packard, M. G. (2002). Post-training reversible inactivation of hippocampus reveals interference between memory systems. Hippocampus, 12(2), 280-4.
Schroeder JP, Wingard JC, Packard MG. Post-training Reversible Inactivation of Hippocampus Reveals Interference Between Memory Systems. Hippocampus. 2002;12(2):280-4. PubMed PMID: 12000124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-training reversible inactivation of hippocampus reveals interference between memory systems. AU - Schroeder,Jason P, AU - Wingard,Jeffrey C, AU - Packard,Mark G, PY - 2002/5/10/pubmed PY - 2002/10/31/medline PY - 2002/5/10/entrez SP - 280 EP - 4 JF - Hippocampus JO - Hippocampus VL - 12 IS - 2 N2 - A post-training reversible lesion technique was used to examine the effects of neural inactivation of the dorsal hippocampus on place and response learning. Male Long-Evans rats trained in one of two versions of a water plus-maze task received post-training intra-hippocampal infusions of the local anesthetic drug bupivacaine (0.75% solution, 0.5 microl), or saline. Post-training intra-hippocampal infusions of bupivacaine attenuated acquisition of the place task and enhanced acquisition of the response task. Delayed (2-h) post-training infusions of bupivacaine did not affect retention in either task. The findings demonstrate (1) enhanced learning after reversible hippocampal lesions that is independent of treatment influences on non-mnemonic factors, and (2) inactivation of the dorsal hippocampus during the post-training memory consolidation period is sufficient to enhance response learning. SN - 1050-9631 UR - https://www.unboundmedicine.com/medline/citation/12000124/Post_training_reversible_inactivation_of_hippocampus_reveals_interference_between_memory_systems_ L2 - https://doi.org/10.1002/hipo.10024 DB - PRIME DP - Unbound Medicine ER -