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Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagocytes.
J Vet Pharmacol Ther. 2002 Apr; 25(2):99-104.JV

Abstract

The properties of azithromycin suggest that it may be an alternative to erythromycin for treatment of Rhodococcus equi pneumonia in foals. To investigate this possibility, the disposition of azithromycin in plasma, polymorphonuclear leukocytes (PMN), and alveolar cells was examined after a single administration in foals. Azithromycin suspension was administered orally (p.o.) at a dose of 10 mg/kg to five healthy 2-3-month-old foals. Two weeks later, azithromycin for injection was administered by intravenous (i.v.) infusion at a dose of 5 mg/kg to the same foals. Plasma samples were collected after p.o. and i.v. administration. Peripheral blood PMN and bronchoalveolar lavage fluid and alveolar cells were collected after p.o. administration. Azithromycin concentrations were determined by reverse-phase high-performance liquid chromatography (HPLC) with coulometric electrochemical detection. Azithromycin p.o. absorption was variable with a mean systemic availability of 39% (+/-20%). The plasma half-life was 16 and 18.3 h after i.v. and p.o. administration, respectively. Azithromycin had a very large volume of distribution (V(d)) of 11.6 L/kg [V(d(ss))] and 12.4 L/kg [V(d(area))]. The large V(d) can be attributed to high tissue and intracellular concentrations, exhibited by the high concentration of azithromycin in PMN and alveolar cells. The PMN half-life was 49.2 h. Dosage of 10 mg/kg of azithromycin p.o. once daily for foals with R. equi pneumonia is recommended for further study.

Authors+Show Affiliations

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12000529

Citation

Davis, J L., et al. "Pharmacokinetics of Azithromycin in Foals After I.v. and Oral Dose and Disposition Into Phagocytes." Journal of Veterinary Pharmacology and Therapeutics, vol. 25, no. 2, 2002, pp. 99-104.
Davis JL, Gardner SY, Jones SL, et al. Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagocytes. J Vet Pharmacol Ther. 2002;25(2):99-104.
Davis, J. L., Gardner, S. Y., Jones, S. L., Schwabenton, B. A., & Papich, M. G. (2002). Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagocytes. Journal of Veterinary Pharmacology and Therapeutics, 25(2), 99-104.
Davis JL, et al. Pharmacokinetics of Azithromycin in Foals After I.v. and Oral Dose and Disposition Into Phagocytes. J Vet Pharmacol Ther. 2002;25(2):99-104. PubMed PMID: 12000529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagocytes. AU - Davis,J L, AU - Gardner,S Y, AU - Jones,S L, AU - Schwabenton,B A, AU - Papich,M G, PY - 2002/5/10/pubmed PY - 2002/6/11/medline PY - 2002/5/10/entrez SP - 99 EP - 104 JF - Journal of veterinary pharmacology and therapeutics JO - J Vet Pharmacol Ther VL - 25 IS - 2 N2 - The properties of azithromycin suggest that it may be an alternative to erythromycin for treatment of Rhodococcus equi pneumonia in foals. To investigate this possibility, the disposition of azithromycin in plasma, polymorphonuclear leukocytes (PMN), and alveolar cells was examined after a single administration in foals. Azithromycin suspension was administered orally (p.o.) at a dose of 10 mg/kg to five healthy 2-3-month-old foals. Two weeks later, azithromycin for injection was administered by intravenous (i.v.) infusion at a dose of 5 mg/kg to the same foals. Plasma samples were collected after p.o. and i.v. administration. Peripheral blood PMN and bronchoalveolar lavage fluid and alveolar cells were collected after p.o. administration. Azithromycin concentrations were determined by reverse-phase high-performance liquid chromatography (HPLC) with coulometric electrochemical detection. Azithromycin p.o. absorption was variable with a mean systemic availability of 39% (+/-20%). The plasma half-life was 16 and 18.3 h after i.v. and p.o. administration, respectively. Azithromycin had a very large volume of distribution (V(d)) of 11.6 L/kg [V(d(ss))] and 12.4 L/kg [V(d(area))]. The large V(d) can be attributed to high tissue and intracellular concentrations, exhibited by the high concentration of azithromycin in PMN and alveolar cells. The PMN half-life was 49.2 h. Dosage of 10 mg/kg of azithromycin p.o. once daily for foals with R. equi pneumonia is recommended for further study. SN - 0140-7783 UR - https://www.unboundmedicine.com/medline/citation/12000529/Pharmacokinetics_of_azithromycin_in_foals_after_i_v__and_oral_dose_and_disposition_into_phagocytes_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0140-7783&date=2002&volume=25&issue=2&spage=99 DB - PRIME DP - Unbound Medicine ER -