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Clinical effectiveness of conventional influenza vaccination in asthmatic children.
Epidemiol Infect 2002; 128(2):205-11EI

Abstract

Influenza immunization rates among young asthmatics remain unsatisfactory due to persistent concern about the impact of influenza and the benefits of the vaccine. We assessed the effectiveness of the conventional inactivated trivalent sub-unit influenza vaccine in reducing acute respiratory disease in asthmatic children. We conducted a two-season retrospective cohort study covering the 1995-6 and 1996-7 influenza outbreaks in 22 computerized primary care practices in The Netherlands. In total, 349 patients aged between 0 and 12 years meeting clinical asthma-criteria were included; 14 children were lost to follow-up in the second season. The occurrence of physician-diagnosed acute respiratory disease episodes including influenza-like illness, pneumonia. bronchitis, bronchiolitis, asthma exacerbation and acute otitis media in vaccinated and unvaccinated children were compared after adjustments for age, prior health care and medication use. The occurrence of acute respiratory disease in unvaccinated children was 28% and 24% in the 1995-6 and 1996-7 season, respectively, and was highest in children under 6 years of age (43%). The overall pooled clinical vaccine effectiveness was 27% (95% confidence interval -7 to 51%, P = 0.11) after adjustments. A statistically higher vaccine protectiveness of 55% (95% CI 20-75%, P = 0.01) was observed among asthmatics under 6 years of age compared with -5% in older children (95% CI -81 to 39%). The occurrence of acute respiratory disease among asthmatic children during influenza epidemics is very high, notably in the youngest. Influenza vaccination may reduce morbidity in asthmatic infants and pre-school children. However, larger, preferably experimental, studies are needed to establish the benefits of vaccination, notably in older asthmatic children.

Authors+Show Affiliations

University Medical Center Utrecht, Julius Center for General Practice and Patient Oriented Research, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12002538

Citation

Smits, A J., et al. "Clinical Effectiveness of Conventional Influenza Vaccination in Asthmatic Children." Epidemiology and Infection, vol. 128, no. 2, 2002, pp. 205-11.
Smits AJ, Hak E, Stalman WA, et al. Clinical effectiveness of conventional influenza vaccination in asthmatic children. Epidemiol Infect. 2002;128(2):205-11.
Smits, A. J., Hak, E., Stalman, W. A., van Essen, G. A., Hoes, A. W., & Verheij, T. J. (2002). Clinical effectiveness of conventional influenza vaccination in asthmatic children. Epidemiology and Infection, 128(2), pp. 205-11.
Smits AJ, et al. Clinical Effectiveness of Conventional Influenza Vaccination in Asthmatic Children. Epidemiol Infect. 2002;128(2):205-11. PubMed PMID: 12002538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical effectiveness of conventional influenza vaccination in asthmatic children. AU - Smits,A J, AU - Hak,E, AU - Stalman,W A B, AU - van Essen,G A, AU - Hoes,A W, AU - Verheij,Th J M, PY - 2002/5/11/pubmed PY - 2002/5/22/medline PY - 2002/5/11/entrez SP - 205 EP - 11 JF - Epidemiology and infection JO - Epidemiol. Infect. VL - 128 IS - 2 N2 - Influenza immunization rates among young asthmatics remain unsatisfactory due to persistent concern about the impact of influenza and the benefits of the vaccine. We assessed the effectiveness of the conventional inactivated trivalent sub-unit influenza vaccine in reducing acute respiratory disease in asthmatic children. We conducted a two-season retrospective cohort study covering the 1995-6 and 1996-7 influenza outbreaks in 22 computerized primary care practices in The Netherlands. In total, 349 patients aged between 0 and 12 years meeting clinical asthma-criteria were included; 14 children were lost to follow-up in the second season. The occurrence of physician-diagnosed acute respiratory disease episodes including influenza-like illness, pneumonia. bronchitis, bronchiolitis, asthma exacerbation and acute otitis media in vaccinated and unvaccinated children were compared after adjustments for age, prior health care and medication use. The occurrence of acute respiratory disease in unvaccinated children was 28% and 24% in the 1995-6 and 1996-7 season, respectively, and was highest in children under 6 years of age (43%). The overall pooled clinical vaccine effectiveness was 27% (95% confidence interval -7 to 51%, P = 0.11) after adjustments. A statistically higher vaccine protectiveness of 55% (95% CI 20-75%, P = 0.01) was observed among asthmatics under 6 years of age compared with -5% in older children (95% CI -81 to 39%). The occurrence of acute respiratory disease among asthmatic children during influenza epidemics is very high, notably in the youngest. Influenza vaccination may reduce morbidity in asthmatic infants and pre-school children. However, larger, preferably experimental, studies are needed to establish the benefits of vaccination, notably in older asthmatic children. SN - 0950-2688 UR - https://www.unboundmedicine.com/medline/citation/12002538/Clinical_effectiveness_of_conventional_influenza_vaccination_in_asthmatic_children_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/12002538/ DB - PRIME DP - Unbound Medicine ER -